"Retinol Palmitate" is a dermatoprotective drug that stimulates skin regeneration, activates the division of epithelial cells, stops keratinization processes, preventing the occurrence of hyperkeratosis. The action of the agent is explained by the presence on the surface of the dermis of unique retinol-binding endings.
general description
"Retinol palmitate" - vitamin A, which has general strengthening properties. The drug stabilizes tissue metabolism, takes an active part in redox processes, in the production of lipids, proteins and mucopolysaccharides. In addition, vitamin A promotes mineral metabolism, cholesterol production processes. In addition, the drug enhances the production of trypsin and lipase, myelopoiesis, and processes of cell reproduction.
Retinol palmitate has excellent qualities for facial skin, having a beneficial effect on the functioning of the sebaceous, lacrimal and sweat glands. In addition, the tool makes the body more resistant to pathologies of the mucous membranes of the intestine and respiratory system, increases the overall protective properties of the immune system.
Vitamin A contained in Retinol palmitate accelerates the division of epithelial cells, thus rejuvenating the population, stops keratinization, and enhances the production of glycosaminoglycans. The product is highly effective in its segment, copes with skin regeneration and is directly involved in the photoreception process (helps a person better adapt in the dark).
Indications for use
After application, the drug easily penetrates into the deeper layers of the skin. The maximum concentration of vitamin in biological fluids is achieved 3-4 hours after lubrication of the damaged area and lasts for 12 hours.
The use of "Retinol palmitate" is indicated if:
- vitamin A hypovitaminosis;
- burns;
- tuberculosis of the epithelium;
- ichthyosis;
- psoriasis;
- eczema
- vitamin A vitamin deficiency;
- frostbite;
- cracks;
- hyperkeratosis;
- neurodermatitis;
- atrophy of the dermis due to prolonged use of glucocorticosteroids;
- seborrheic dermatitis;
- pyoderma;
- skin pathologies characterized by delayed epithelization and dryness;
- rickets;
- erosion;
- atopic dermatitis;
- skin ulcers.
In addition, the drug is recommended for use in complex treatment:
- a variety of infectious and inflammatory diseases - influenza, measles, bronchitis, dysentery, tracheitis;
- defects of the visual system - hemeralopia, keratomalacia, retinitis pigmentosa, eczematous trauma to the eyelids, xerophthalmia;
- diseases of the digestive tract - peptic ulcer of the duodenum or stomach, erosive gastroduodenitis;
- cirrhosis of the liver.
Among other things, Retinol palmitate is often prescribed to prevent calculi in the urinary and biliary tract.
Release form and composition
The drug is produced in several varieties that differ in content.
- Dragee tablets. Capsules have a spherical shape with a snow-white or cream shell, a uniform coating. The active substance of the dragee is vitamin A in oil form. In addition to the main ingredient, the capsules contain beeswax, sucrose, wheat flour, talc, peppermint essential oil, starch syrup, refined vegetable oil.
- Oily solution for oral administration. Transparent liquid, light yellow, odorless in a glass bottle. The main active ingredient is vitamin A, additional ingredients: butylhydroxytoluene, butylhydroxyanisole, rapeseed oil.
- Ointment and cream with a similar composition.
Instructions for use "Retinol Palmitate"
Use the drug should be under the supervision of a specialist. Inside, the medicine must be taken after eating late in the evening or early in the morning.
The instruction "Retinol palmitate" indicates the correct dosage of the drug. With minor vitamin deficiencies, the amount of medication should be up to 33,000 IU per day for an adult. In case of defects of the visual system, such as retinitis pigmentosa, xerophthalmia, hemeralopia, the dosage can be increased to 10,000 IU. Children are recommended to take 2000-5000 IU throughout the day, taking into account age.
If the patient uses Retinol palmitate for facial skin (general healing and getting rid of pathologies), then the dosage should be in the range of 5000-10000 IU per day, and for children - twice as much.
Oil solutions can be used externally in case of burns, frostbite, ulcers, lubricating the damaged area 6-7 times throughout the day and covering with bandages. Together with them, the patient can use retinol intramuscularly or orally
The ointment should be applied in a thin layer to the injured areas twice during the day: morning and evening. If the patient has very flaky skin, it is necessary to use an occlusive dressing. The duration of the drug can be from 4 to 12 weeks. The duration of therapy is determined by a specialist.
According to the instructions for use of Retinol palmitate, a single dose of the medication should not be more than 50,000 IU for adult patients and 5,000 IU for children. The daily norm can be up to 100,000 IU and 20,000 IU, respectively.
To eliminate acne and ichthyosiform erythroderma in an adult, a dosage of the drug in the range of 100-300 thousand IU is used.
Side effects
According to the instructions of "Retinol palmitate", in patients with an excessively high sensitivity to the components of the drug may provoke manifestations of allergic reactions.
Sometimes, with prolonged use, seizures, excessive dryness of the mucous membranes and skin appear. According to reviews of Retinol palmitate, some patients also noticed an increased sensitivity of the skin, which manifested itself even with minor touches. Typically, these signs do not bring significant discomfort and pass on their own with a lower dosage or a temporary abandonment of the drug.
In the case of too long vitamin intake by adults in an amount of more than 200,000 IU, and by children of 100,000 IU, the occurrence of hypervitaminosis or intoxication of the whole organism is likely. Symptoms in this phenomenon are as follows:
- gagging;
- pain in the joints and bones;
- nausea;
- migraine;
- lack of coordination;
- lethargy, loss of strength;
- drowsiness;
- hyperemia of the face.
In the treatment of acne, a week later, an exacerbation of local inflammation is likely, which in the future stops on its own. This condition does not require additional treatment.
Contraindications
In fact, Retinol palmitate has very few restrictions on its use. Contraindications for use are:
- chronic pancreatitis;
- hypersensitivity or intolerance to the components of the drug;
- acute inflammatory skin pathologies;
- hypervitaminosis A;
- gallstone disease.
In addition, with great caution, the medicine should be treated for those patients who suffer from:
- viral hepatitis;
- jade;
- cirrhosis of the liver;
- alcoholism;
- renal failure;
- chronic heart failure of the second and third degree.
Children and elderly people should also take the remedy carefully.
Special recommendations
It is not recommended to use “Retinol palmitate” for the face in order to eliminate excessive dryness of the epidermis, wrinkles, defects of the visual organs, as well as infections associated with a lack of vitamin A.
Refuse should be given to those who use tetracyclines for a long time.
To prevent overdose in parallel with the drug, it is undesirable to take other medicines containing vitamin A.
In the case of simultaneous administration of cholestyramine, "Retinol palmitate" should be used one hour before it or 5-6 hours after it.
Use during pregnancy
The medication is contraindicated for use in the first trimester of bearing a fetus. During breastfeeding, it is undesirable to lubricate the skin of the chest with ointment.
External use of "Retinol palmitate" during the period of bearing and feeding the baby is permissible if the desired result from therapy exceeds the possible risks for the mother and child.
Overdose
Acute oversaturation of the body manifests itself in the form of hypervitaminosis A. Symptoms of this phenomenon in adults:
- bleeding gums;
- migraine;
- drowsiness and lethargy;
- diarrhea;
- peeling lips;
- Dizziness
- confusion of consciousness;
- nausea;
- irritability;
- ulceration and dry mouth;
- bifurcation in the eyes;
- osteoporosis.
Children may experience symptoms such as:
- sweating
- temperature rise;
- rashes;
- vomiting
- fatigue.
With chronic intoxication, the patient has:
- asthenia;
- hypertension
- vomiting
- cramps
- lack of appetite;
- bone pain
- astralgia;
- orange spots on the skin;
- photosensitivity;
- dry mouth
- hair loss;
- hemolytic anemia.
In the event of the appearance of such symptoms, you should immediately abandon the use of the drug. Adult patients can remove excess vitamin A from the body with a small amount of alcohol. Overdose therapy is extremely symptomatic. In case of too strong manifestations of the pathological condition, glucocorticosteroids can be prescribed.
According to numerous reviews, Retinol palmitate rarely causes discomfort.
Interaction with other drugs
In order to avoid an overdose of vitamin A, it is undesirable to take "Retinol palmitate" together with medicines containing the same active substance.
It is not recommended to use the drug in combination with tetracycline antibiotics.
Reduces the risk of hypervitaminosis D. Absorption of the active components of the drug can disrupt nitrites, neomycin, colestipol, colestyramine.