"Reserpine": instructions for use, indications, composition, analogues and reviews

In the article, we will consider the Reserpine preparation instructions for use, price, reviews and analogues.

It is a complex sympatholytic drug that has a hypotensive, antipsychotic and sedative effect. The active substance of this drug is one of the alkaloids of such a rare plant as snake rauwolfia.

Pharmacokinetics

The drug "Reserpine" is an antispasmodic, which has for the most part an effect on the nervous sympathetic system, the reduction of which allows you to activate the parasympathetic. It has a compensatory effect.

This tool can cause a persistent decrease in blood pressure. This is indicated instructions for use. At what pressure it is permissible to prescribe Reserpine, many are interested. It is effective at elevated.

The antipsychotic effect is based on a decrease in the concentration in neurons of some neurotransmitters, they include serotonin and dopamine. The composition of the drug includes the active substance - reserpine, hydrochlorothiazide, dihydralazine sulfate.

"Reserpine" produces the following therapeutic effect on the human body:

• depresses heart contractions;
• reduces total peripheral vascular resistance;
• deepens and enhances physiological sleep;
• slows down the metabolism in patients suffering from hypertension and coronary atherosclerosis;
• strengthens the influence of such a group of drugs as sleeping pills and painkillers;
• stabilizes the metabolism of fats and proteins;
• normalizes breathing, it becomes rarer and deeper;
• the pupil narrows, the temperature decreases;
• the production of hydrochloric acid by the stomach is activated;
• intestinal motility increases;
• blood supply to the kidneys improves;
• increased renal glomerular filtration.

What else does the application instruction for Reserpine tell us?

The drug also has a cumulative effect, since the primary effect is observed after several days of its use, the maximum effect is achieved after 2-6 weeks, if the intake was regular.

The time for complete elimination of the drug from the body is approximately 4-6 weeks.

What are the indications for Reserpine according to the instructions for use?

Indications

"Reserpine" is used for the following pathologies:

• mental illness of vascular origin;
• hypertension, when there is a persistent increase in blood pressure;
• psychoses that occur with high blood pressure;
• neurosis;
• arterial hypertension;
• thyrotoxicosis;
• manic excitement with cycloid psychosis;
• psychomotor agitation in patients with schizophrenia.

Possible contraindications

According to the instructions for use, “Reserpine” may not be used by all patients who need it, therefore its use should be excluded with:

• peptic ulcer of the duodenum and stomach;
• Depression
• bronchial asthma;
• serious diseases of the heart and blood vessels;
• bradycardia;
• nephrosclerosis;
• Parkinson's disease;
• cerebral arteriosclerosis;
• the appointment of therapy through electrical pulses;
• hypersensitivity to the components of this drug;
• respiratory failure;
• gallstone disease;
• pheochromocytoma;
• angle-closure glaucoma;
• chronic heart failure;
• breastfeeding and pregnancy.

Side symptoms

Below will be presented the price and reviews for Reserpine.

Instructions for use indicate that when using the drug, undesirable symptoms may also occur:

• digestive system: patients notice pain in the epigastric region, symptoms of dyspepsia, a feeling of dryness in the mouth, a strong decrease in appetite, bleeding from the intestines and stomach is rarely observed;
• nervous system: headaches, sleep disturbances, anxiety of the patient, excessive fatigue, decreased libido, hyporeflexia are recorded;
• vessels and heart: arrhythmia, bradycardia and pain in the space behind the sternum are noted;
• urinary system: responds to the drug "Reserpine" with metabolic disorders of salts and water, manifested in dryness and peripheral edema of the mucous membranes, in addition, dysuria and anuria may appear;
• epidermal integument: urticaria, skin itching, exacerbation of herpetic infection;
• there have been cases of impaired liver function and weight gain.

Instructions for use "Reserpine"

The drug is taken orally after a meal and washed down with water or any liquid in sufficient volume. In accordance with the instructions, the drug is prescribed for the treatment of the initial stage of hypertension in a dosage of 0.1 mg twice a day. The duration of its use is approximately seven days. In the absence of a therapeutic effect during this period, it is recommended to increase the dose of the drug to 0.5 mg, also divided into two doses.

If a stable state of a person has been achieved and blood pressure has reached the required values, then the dosage is gradually reduced to 0.1 mg. The medicine is then taken for maintenance therapy.

A full treatment course lasts from two to four months.

Also, the medicine can be prescribed for complex therapy for other indications (tachycardia, thyrotoxicosis, late gestosis) and used along with other drugs. In such cases, it is assigned strictly individually.

Overdose

According to the instructions for use with Reserpine tablets, during their use at excessive dosage, symptoms such as:

• sudden decrease in blood pressure;
• diarrhea;
• bradycardia;
• nightmares;
• parkinsonism;
• coma;
• vomiting
• hypothermia;
• tremor;
• violations of the liver.

Therapy with such signs is symptomatic, it consists in the introduction of intravenous drugs. In special situations, an intravenous infusion of pressor amines is required.

Drug Interactions

Instructions for use with "Reserpine" also reports that the parallel use of the drug and other medications always requires specialist supervision, because this substance can interact with many of the drugs, weakening or enhancing their therapeutic effect. We describe such interactions in more detail.

1. Digitalis products increase the possible risk of bradycardia.
2. Joint use with ethanol, barbiturates, tricyclic antidepressants, inhalation anesthesia drugs enhances their effect.
3. "Reserpine" can reduce the effectiveness of antiepileptic drugs and anticholinergic drugs, as well as reduce the analgesic effect of morphine.
4. "Reserpine" contributes to the longer lasting effect of direct adrenomimetic drugs.
5. When prescribing drops for the eyes, an increase in blood pressure is recorded.
6. When tricyclic antidepressants are used, the hypotensive effect of Reserpine decreases.
7. The drug "Fenfluramine" enhances the hypotensive effect of the drug, and "Methyldopa" develops a state of depression.

Cost

The price of the drug ranges from 380-420 rubles. It depends on the pharmacy network and the region.

Analogs

Reserpine has analogues such as Christoserpin, Eskazerp, Rausedil, Raupazil, Alserin, Raused Serfin, Tenserpin, Kvescin, Rausedan, Serpin, Roxinoid "," Serpiloid "," Sedaraupin "," Tenserpine "," Serpat.

Reviews

The drug "Reserpine" has collected mixed reviews of people: some patients believe that it has a positive therapeutic effect, while others note that there are many undesirable side symptoms.

Some patients with high blood pressure, taking "Reserpine" instead of the usual means for them, notice that his indicators are returning to normal, nervous conditions are less and less observed. Moreover, the drug was taken first in a minimum dosage, and then it was increased in accordance with the scheme developed by the doctor. Positive changes were observed after two months.

Others note that Reserpine helped normalize the pressure, but two days later long headaches began to appear, which disappeared only by the fifth week of treatment with this drug.

We reviewed the instructions for use with Reserpine, price, reviews and analogues.