Nowadays, many women suffer from infertility. Very often this is due to a violation of ovulation, which is caused by endocrine changes. In such cases, the drug "Klostilbegit" comes to the rescue. Reviews of the drug indicate that this tool has helped many women find the joy of motherhood. The drug does not contain hormones, but normalizes the production of estrogen and gonadotropins in the female body and is a powerful stimulator of ovulation. Unlike other similar drugs, this medicine is much less likely to cause unpleasant side effects. Next, the properties and effects of the drug will be considered, reviews about “Klostilbegit” and results for women in the treatment of infertility will be given.
What is anovulation
In the ovaries of a woman, follicles are formed monthly. One of them looks at the ultrasound as the largest and most developed. Such a follicle is called dominant. In the middle of the menstrual cycle, an egg leaves it. This process is called ovulation. It is controlled by the pituitary gland and hypothalamus. Follicle-stimulating and luteinizing hormones (FSH and LH) are responsible for the formation of a dominant follicle and the release of an egg.
However, as a result of various pathologies and hormonal disruptions, ovulation may be absent, which makes conception impossible. In such cases, doctors talk about anovulation. In some cases, this may be due to natural causes. For example, the functioning of the ovaries ceases in women during menopause, and the use of hormonal contraceptives also blocks the ovulation process.
However, quite often anovulation in women of childbearing age is associated with many diseases:
- Polycystic Ovary Syndrome (PCOS). This is a fairly common violation. In the woman’s body, the level of male hormones rises, because of this the follicles mature, but do not reach the state of ovulation. Ultrasound in the ovaries reveals many vesicles filled with fluid.
- Injuries and brain tumors. These pathologies can lead to impaired function of the brain: the pituitary and hypothalamus. As a result, ovulation may disappear in a woman.
- Obesity or anorexia. Excess or deficiency of adipose tissue causes hormonal imbalance in the body.
- Diseases of the thyroid gland or adrenal gland. Pathologies of these organs can provoke hyperandrogenism - an increase in the level of male hormones in the body of a woman. The result is a lack of ovulation.
How to understand that a woman has abnormalities in the exit of the egg from the dominant follicle? Usually anovulation makes itself felt by the following symptoms:
- menstrual irregularities (up to the complete cessation of menstruation - amenorrhea);
- hair growth on the body and face according to the male type (hirsutism);
- intermenstrual uterine bleeding;
- the absence of pregnancy with regular sexual activity for 1 year without the use of contraceptives;
- proliferation of the endometrium (determined by ultrasound examination).
If a woman is planning a pregnancy, then in such cases the drug "Klostilbegit" is prescribed. Reviews of doctors indicate that this remedy does not cure the disease itself, which caused infertility. The drug only stimulates ovulation and promotes the onset of pregnancy, therefore, the medicine is used in the treatment of only those patients who are planning to have a baby soon.
Pharmacological properties of the drug
Often the cause of anovulation is an excess of estrogen in the body. They block the formation of pituitary hormones, which are responsible for the release of the egg. The active component of Clostilbegit is clomiphene citrate, which binds estrogens. The body increases the activity of gonadotropic hormones, which are responsible for the ovulation process.
This medicine is produced in the form of tablets. Each of them contains 50 mg of the active ingredient. It is important to remember that the drug should never be taken on its own. Before his appointment, it is necessary to take a blood test for hormones. In addition, tablets are taken under the supervision of an ultrasound scan.
You can often find negative reviews of women about Klostilbegit - in all cases, patients were self-medicating. This not only did not lead to pregnancy, but also caused serious side effects. It is important to remember that this medicine actively affects the hormonal background, and if it is used without indications, it will cause malfunctions in the endocrine glands. In addition, there are contraindications to the appointment of this medication.
Indications and contraindications to the use of the drug
The drug is effective only in the anovulatory form of endocrine infertility. If problems with conception are caused by other reasons, then this tool will not help. Before prescribing drugs, a comprehensive examination of the body for hormones is carried out. The drug is used for the following diseases, accompanied by a lack of ovulation:
- The complete absence of menstruation for a long period (amenorrhea).
- Rare menstruation with an increase in the cycle of more than 45 - 60 days (oligomenorrhea).
- Polycystic ovaries (Stein-Leventhal syndrome).
- Too long maturation of the dominant follicle and delayed ovulation.
- Chiari-Frommel syndrome - a disease accompanied by the cessation of menstruation, atrophy of the reproductive organs and the release of milk from the mammary glands without regard to feeding.
However, there are conditions and diseases in which this drug is contraindicated. These include:
- pregnancy;
- ovarian cysts (except polycystic);
- thyroid and adrenal gland diseases;
- tumors dependent on hormone production;
- visual impairment;
- insufficiency of the hypothalamus function;
- malignant neoplasms;
- proliferation of the endometrium;
- uterine bleeding of unknown origin.
How to take the drug
The drug begins to be consumed on the 5th day of the menstrual cycle. If a woman suffers from amenorrhea, then medication can be started any day. In this case, the following algorithm must be observed:
- In the first month, take 50 mg (1 tablet) of the drug from 5 to 10 days of the menstrual cycle. In this case, with the help of ultrasound, the growth of follicles in the ovaries is monitored. If ovulation occurs between 11 and 15 days, then this indicates a positive result of treatment.
- If the therapy was ineffective, then the next month the dosage is doubled. Assign 100 mg (2 tablets) on the same days of the cycle.
- If the result is still absent, then treatment in a dosage of 100 mg is repeated again in the next cycle.
If there is no result for 3 months, take a break for 90 days. Then the treatment is repeated again according to the above scheme.
Reviews about Klostilbegit and the results of therapy indicate that in many women pregnancy began after the first month of treatment. In some patients, ovulation was observed with a three-month course of therapy after discontinuation of the drug.
Unwanted effects
During treatment, it is very important to monitor the condition of the ovaries. Admission "Klostilbegita" contributes to their increase. Hyperstimulation of the ovaries may occur, which leads to their rupture. Therefore, during the treatment period, ultrasound should be done regularly.
In reviews of Klostilbegit, other adverse events are reported:
- the appearance of spots in front of the eyes;
- dyspeptic symptoms (nausea, diarrhea);
- slowing down the reaction;
- headache;
- dizziness
- sleep disturbances;
- intermenstrual bleeding;
- dry vaginal mucosa.
These manifestations are transient in nature and disappear when the drug is withdrawn.
It is important to remember that this tool promotes the growth of fibroids and ovarian tumors, therefore, in the presence of neoplasms of the reproductive organs, the drug is strictly contraindicated.
What to do if the result is unsuccessful
There are cases when, even after prolonged treatment with the drug, a woman still does not ovulate. Reviews about "Klostilbegit" indicate that this is often noted. However, you cannot use the drug for too long, as this increases the risk of tumor formation. What to do if the treatment result was unsuccessful?
In the event that therapy has been ineffective, the doctor uses additional methods to stimulate ovulation, but before that you need to establish the exact cause of infertility.
Sometimes violations of the egg cell output are associated with a deficiency of the hormone progesterone. In this case, the treatment with “Klostilbegit” is supplemented with the use of the drug “Dufaston”, which is used from the 5th to the 25th day of the cycle.
It is very important to remember that long attempts to stimulate ovulation deplete the ovarian reserve, which leads to an early onset of menopause, so you can use “Klostilbegit” for no more than 6-7 cycles in life.
If a woman has initial signs of ovarian function depletion, then Klostilbegit is supplemented with other drugs. The following treatment regimen is used:
- Reception of "Klostilbegit" begins with 3-5 days of the cycle, while constantly doing an ultrasound to monitor the growth of the follicle.
- When the dominant follicle reaches a sufficient size, make an injection of a drug containing chorionic gonadotropin. A few days after the injection, ovulation occurs.
- In addition, from 5 to 21 days of the cycle, the patient takes the drug "Proginova". It contains estrogens and prevents premature ovarian reserve depletion.
Multiple pregnancy
Reviews of "Klostilbegit" suggest that in some patients, after stimulating ovulation, a multiple pregnancy begins. However, such a result is observed infrequently. According to medical statistics, after treatment with this drug, twins or triplets were born in only 10-12% of women. It can be concluded that this medicine cannot be used for special planning of multiple pregnancy.
Doctors reviews
Experts leave positive feedback on the stimulation of ovulation with Klostilbegit. According to doctors, a positive result after the first attempt was observed in about 50% of cases. The success of stimulation largely depends on the degree of hormonal disorder and the age of the patient. After the fifth attempt at stimulation, pregnancy occurred in 70-75% of women.
Patient Reviews
Patients leave a lot of positive reviews about the stimulation of “Klostilbegitom”. This medicine is especially effective in treating polycystic ovary syndrome. Many women suffering from PCOS have managed to become pregnant after many years of infertility. However, one must remember that the result does not always occur on the first try. In many cases, pregnancy occurred in the second or third month of therapy, but even in the first days of treatment with an ultrasound examination, the response of the ovaries to stimulation was clearly visible.
However, there are times when the drug did not help and the long-awaited pregnancy did not occur. If there is no result, an additional examination should be done. It is possible that infertility is associated not with anovulation, but with other causes. In such cases, the doctor may recommend other treatment methods. In the absence of the effect of drug therapy, the patients are shown an IVF procedure.