Conflicting reviews about "Fraxiparin" during pregnancy are fully justified, since the drug did not pass a full-fledged clinical trial. It is not recommended for use during the period of gestation, unless the therapeutic effect exceeds the possible risk.
Thromboembolism is a dangerous pathology leading to blockage of blood vessels, impaired blood flow with the further development of ischemia or heart attack. The use of "Fraxiparin" during pregnancy is quite possible, since dysfunction can lead to disability and death.
The importance of full blood circulation during pregnancy
From the first weeks after conception, the body of a pregnant woman increases the volume of circulating blood. Peak intensity observed at 31-34 weeks. In the normal state, the amount of the liquid part of the blood increases, since its excessive viscosity is lost, there is no risk of blood clots.
There is a certain percentage of women with increased blood coagulation. Such deviations are possible as a result of hormonal imbalance, decreased activity, or as a result of an infectious disease. It is worth noting that the physiological process in the body itself can provoke hypercoagulation.
Traffic jams create obstacles for oxygen delivery and the transition of pathology into a chronic course is dangerous for the fetus and can negatively affect the nervous system, blood vessels and myocardial function.
The danger of the condition is that the blockage of the pulmonary artery usually ends in death.
From the first weeks of pregnancy, a woman should be registered with a leading specialist. Having revealed the first signs of a threat, preventive methods of control are prescribed. Dietary nutrition, sports and, if necessary, anticoagulant drugs help well.
Who is indicated for the administration of Fraxiparin?
According to the instructions, “Fraxiparin” during pregnancy is used for prophylactic purposes in order to prevent excessive blood clotting, which subsequently contributes to the development of thrombosis. Also, the drug is indicated for therapeutic use:
- thromboembolism;
- violation of placental blood flow;
- signs of fetal hypoxia;
- angina pectoris;
- heart attack (without Q).
It is a commonly prescribed tool that prevents complications from surgical interventions, orthopedic manipulations. During hemodialysis does not allow blood coagulation.
Pregnant women are prescribed the drug with extreme caution when there is a risk of obstetric complications and possible side effects on the scales. With high blood coagulability, when the body does not produce anticoagulants, in spite of negative reviews, “Fraxiparin” must be administered during pregnancy. Thus, the real threat of fetal fading is excluded. Thick blood interferes with the correct fixation of the embryo to the wall of the uterus, the formation of the placenta.
How long can the drug be prescribed?
Doctors have no goal of harming the patient. Gynecologists are convinced that “Fraxiparin” does not harm the mother and the unborn child, but not in the early stages. The appointment of the drug is excluded in the first trimester, as it can provoke a pregnancy failure. In the second trimester, the drug is prescribed by a leading specialist under control, if the test results indicate high coagulability.
The composition of "Fraxiparin" in injections
The active substance "Fraxiparin" is nadroparin calcium. As auxiliary components, calcium hydroxide or diluted hydrochloric acid are used.
The tool is endowed with a powerful antithrombotic effect and emergency long-term activity.
The introduction of the solution leads to the absorption of the active substance by 88%. The maximum plasma saturation was recorded after 3-4 hours. It has the property of being metabolized in the liver, excreted from the body per day. The active effect of the drug persists until 18 hours.
It should be noted that pregnant women with kidney failure are not prescribed the drug, since in this case it accumulates in the kidneys. If the doctor has decided to continue therapy, the dosage should be reduced.
Release form
The drug is released in the form of a solution for injection. Packaged in disposable syringes with a dosage of 0, 3/2850 IU; 0, 4/3800 IU; 0, 6/5700 IU; 0, 8/7600 IU ml. The amount of “Fraxiparin” introduced into the stomach during pregnancy is determined by a leading specialist. The amount of the substance is affected by the weight of the patient, the presence of contraindications, concomitant pathologies, the general condition of the woman. The duration of the course of therapy is also calculated by the doctor. Sometimes the injections are indicated throughout the gestation period, but it can be concluded from numerous reviews - “Fraxiparin” is canceled at 36-37 weeks of gestation. Further monitoring of the expectant mother is carried out in a hospital.
What is the drug
Blood vessel dysfunction, violation of the integrity of warm-blooded, leads to the activation of barrier functions. Thrombocin begins to be synthesized intensively, making blood more viscous. Due to cell adhesion, a clot forms that blocks the ducts. Continuous production of thrombocin develops thrombocytosis - the formation of blood clots in intact vessels.
Solution for injection - anticoagulant. Its action is aimed at stopping the processes of thrombus formation. The main active ingredient is fraxeparin-nadroparin calcium. After administration, the drug reacts with proteins, diluting blood plasma.
Violation of blood circulation leads to a lack of proper nutrition and oxygen supply to organs and tissues, the fetus suffers from hypoxia. Subsequently, such a development of events is fraught with spontaneous abortion.
How to make an injection
There is another form of release - tablets, but their pregnant women are not prescribed to exclude the effect on the digestive system and liver function. Injections are sterile and can be administered subcutaneously or intravenously. During the period of gestation, doctors use the subcutaneous method and reviews of “Fraxiparin” during pregnancy are not very good, as the procedure is painful. Sometimes just the fact that injections are made in the abdomen scares patients the most; bruises and bumps remain. The course of therapy is long, often women continue treatment at home, so you need to know how to inject Fraxiparin during pregnancy.
Algorithm of actions:
- take the syringe with the needle up, release air until a droplet appears on the end of the needle;
- a cotton swab moistened with alcohol is used to treat the injection site (midline of the abdomen, 2 fingers below the navel);
- perform the capture of folds of skin with your fingers vertically;
- a needle is inserted into the upper part of the fold, perpendicular to the skin surface;
- the solution is administered smoothly, slowly;
- after the needle is removed, cotton soaked in alcohol is applied to the puncture site.
Do not rub the area of ​​the skin after administration of the drug. Also, do not be active for a quarter of an hour. The recommended dose for the administration of Fraxiparin during pregnancy is 0.3 mg.
Features of the action of injections during pregnancy
The female body changes with increasing gestational age. Along with volumes, the number of blood vessels and capillaries increases. Blood stasis leads to the development of pathological processes and chronic respiratory failure of the fetus. It is also necessary to understand that in the later stages, compression of the veins of the small pelvis by the uterus is inevitable, which leads to a violation of the outflow of blood from the veins of the legs. According to reviews, Fraxiparin during pregnancy is an effective drug to prevent blood clots. It is important to exclude thrombosis of the lower extremities so as not to provoke the development of pulmonary embolism. If you delve into the instructions, "Fraxiparin" during pregnancy is not dangerous, but its use is shown only in case of urgent need.
Are injections dangerous during pregnancy?
Today, "Fraksiparin", according to doctors, is considered an effective tool for the prevention and treatment of thrombosis. The very fact that the substance is injected into the stomach acts on some frightening, but do not panic. It is necessary to trust the actions of a specialist. The solution is injected into the umbilical zone, but this does not harm the fetus and does not affect the course of pregnancy. Increased blood coagulation is more dangerous, therefore, it is worth casting aside doubts and channeling energy to the restoration of vascular conduction - this is where caring for mother and baby is manifested.
Doctors with experience reject stereotypes and negative reviews about “Fraxiparin” during pregnancy, since the drug eliminates the threat of spontaneous interruption and treats blood clots, regardless of the complexity of the case.
Contraindications during pregnancy
Before prescribing a therapeutic regimen, the doctor must correctly assess the situation. If the benefit to the mother is greater than the alleged harm to the fetus, only contraindications can be a ban on use.
During pregnancy, the reason for refusing treatment may be:
- individual immunity to the active substance;
- deficiency of coagulation factors, bleeding (coagulopathy);
- thrombocytopenia;
- organic organ damage;
- injuries to the head, back, eyes;
- ineffectiveness of the use of antiplatelet agents.
Treatment is carried out under the supervision of a leading specialist. Pay attention to possible manifestations of side effects in the form of a rash, itching, urticaria. A more serious reaction requiring emergency intervention is Quincke's edema, anaphylactic shock. Excess volumes can cause bleeding. Judging by the reviews, even the minimum dosage is 0, 3 of “Fraxiparine” during pregnancy, it requires specialist control.
Patients with impaired renal function, with severe renal failure, do not use treatment with this drug. The doctor selects analogues that are less fatal to the work of organs. In mild to moderate form, the course can be taken under the supervision of a specialist, but with a reduced dosage, to prevent the development of thromboembolism.
Use with caution
"Fraxiparin" can be prescribed for high risk of bleeding, under the supervision of doctors in the event of:
- liver failure;
- renal failure;
- arterial hypertension;
- peptic ulcers;
- failures in blood circulation in the membrane and retina of the eye;
- the need for therapy for more than a decade;
- combination with drugs that increase the likelihood of bleeding.
Who is at risk
A gynecologist examines the patient’s history in detail. In the event that a pregnant woman has previously had non-developing pregnancies, inability to bear the fetus, phlebological diseases - the course of therapy with Fraxiparin will most likely be prescribed.
special instructions
Before using any drug belonging to the class of low molecular weight heparins, it is necessary to carefully study the instructions. Particular attention should be given to dosage units.
It is also important to consider:
- the alternation of low molecular weight heparin preparations is unacceptable;
- the drug of the same name with the prefix "Forte" requires a dosage review;
- graduation on syringes is necessary to select a dose according to weight;
- the drug is not administered intramuscularly;
- in the process of therapeutic actions, clinical monitoring of changes in platelet concentration is carried out.
In rare cases, with arterial or venous thrombosis, thrombocytopenia occurs, which should be considered when:
- thrombocytopenia;
- low platelet count;
- with negative dynamics of the diagnosed thrombosis;
- DIC syndrome.
The above cases are a reason to interrupt treatment.
If the question arises about the possibility of driving, then there is no data on the effect of Fraxiparin on the ability of a pregnant woman to cope with mechanisms.
When buying a drug, pay attention to expiration dates, packaging integrity. To avoid falsification or transaction with unscrupulous sellers, injection is recommended to be purchased in pharmacies or trusted stores on the Internet.
The storage temperature of the drug should not freeze the solution. Also, the thermometer can not rise above +30. The drug from list B is stored in places inaccessible to children.
Drug compatibility
In order to prevent the development of hyperkalemia, Fraxiparin is not used simultaneously with potassium-sparing diuretics, potassium salts, ACE inhibitors, Cyclosporin, Tacrolimus.
It must be borne in mind that non-steroidal PVP and Aspirin, indirect anticoagulants enhance each other's action.
The combined use of antiplatelet agents can trigger the discovery of bleeding.
Analogs
If for some reason it was not possible to purchase Fraxiparin, its structural analogue for the active substance is Fraxiparin Forte.
If the patient is diagnosed with individual immunity to the drug or there are other contraindications to “Fraxiparin”, the doctor may prescribe a drug from the same pharmacological group with a different active substance in the structure:
- “Agioks”, “Angioflux”, “Anfibra”, “Arikstra”.
- Warfarex, Viatrombe, Warfarin.
- Calciparin, Clexane, Xarelto.
- “Lavenum”, “Lyoton”, “Marevan”.
- Pelentan, Piyavit, Pradaksa.
- Seprotin, Sincumar.
- "Thrombophobia", "Trombless", "Troparin".
- “Zibor”, “Fragmin”, “Fenilin”.
- "Elikvis", "Emeran", "Exanta".
The analogue is selected by the attending physician, taking into account all the features of a particular case.
Conclusion
Is it advisable to prescribe low molecular weight heparins during the period of gestation - the question remains open. It should be borne in mind that the instruction was drawn up several decades ago, and tests capable of guaranteeing safety were not carried out. Nevertheless, there are women in dire need of anticoagulant treatment. It is not worthwhile to rely on reviews about the use of Fraxiparin during pregnancy. Only a doctor, taking into account all the nuances (the condition of the patient, concomitant pathologies, term), can determine the need for the use of the drug “Fraxiparin”.