Fibrin is a protein that is the end result of blood coagulation. It is formed as a result of exposure to fibrogen thrombin.
Fibrin is an insoluble protein produced in the body as a response to bleeding. This protein is a solid element consisting of fibrous filaments. The progenitor of fibrin is fibrinogen. This is a protein produced by the liver. He is in the blood. If tissue damage occurs, bleeding occurs. To stop it, thrombin begins to work. It affects fibrinogen, thereby provoking its conversion to fibrin.
First, protein molecules combine into long strands that entangle a platelet, creating a coarse mass. Gradually, it hardens and contracts, forming a bloody clot. The compaction process is stabilized by the fibrin-stabilizing factor.
The role of fibrin in inflammation
Fibrin production and inflammation are two closely related processes. Protein plays an important role in contact with collapsing, damaged tissue. Thrombokinase released from the tissue comes into contact with fibrinogen.
When blood coagulation, all toxic substances are clogged in the clot. This feature of the effect of protein in the inflammatory process protects the body from the further spread of toxins and their negative effects. A similar reaction is called fixation. Thus, fibrin is also a defender of the body from toxins.
Body protection
The formation of insoluble fibrin helps protect the body from blood loss, as well as from inflammatory processes. However, such a reaction causes pain and swelling, tissue damage, impaired functionality. Subsequently, this is eliminated by reparative processes. At their early stage, special substances are produced that cause the depolymerization of fibrin. A similar reaction, even at the very beginning of the inflammatory process, can inhibit the effect of protein on the pathological focus.
Fibrin function
When fibrinogen is converted into fibrin, special enzymes located in the focus of inflammation begin to act as inhibitors. This process is manifested by the polymerization of fibrinogen into fibrin. Based on this, the function of proteases is determined, which consists in the thinning of materials by the method of splitting fibrin and other protein molecules into peptides and amino acids. Also, the function of proteases is to inhibit the production of large molecules of an insoluble type.
Experiments
Scientists conducted experiments on animals, during which it turned out that proteases introduced from the outside before the inflammatory process are able to prevent its development completely, and in some cases the pathology proceeded in a mild form. Experience has shown that the use of tryptic substances in most cases stops the development of inflammatory processes at the onset of the disease.
With the introduction of prophylactic doses of enzymes, protein formation decreased.
Fibrin is not just a protein, but the creator of a protective barrier around a pathological focus that protects against a disease. Subsequently, this insoluble component serves to build connective tissue. He also participates in regeneration processes. The formation of scar tissue depends on the duration of conservation and the amount of fibrin production by the body.
So what is fibrin and what is it for? This substance is formed by the cells of the body in such an amount that is necessary to quickly stop bleeding and which will help quickly restore damaged tissue. In some cases, fibrin is a pest. If it is produced and stored in large quantities, then protein can harm the body. As far as we know, fibrinolysis is a long process that is not able to dissolve all excess protein. Moreover, certain conditions are necessary for this process.
To get rid of excess fibrin, special treatment with enzymes is prescribed.
Enzyme treatment
Recently, special attention has been paid to the properties of enzymes. This is especially true for proteases. For the treatment of fibrin enzymes, substances of this type are used. They help to dissolve excess protein, thereby preventing serious complications in the form of blood clots.
The properties of proteolytic enzymes are different. They are able to exert fibrinolytic and immunomodulatory effects on the body, as well as improve blood circulation, work as decongestants, anti-inflammatory substances.
Since thrombosis is based on the production of fibrin, a protease is required that triggers a cleavage reaction of this substance. Without such an enzyme, it is impossible to break down a protein into molecules; therefore, there will be no improvement in blood microcirculation.
With local exposure to protease, it is possible to remove necrotic plaque, resorption of fibrinous formation, thinning of viscous secretions.