Among certified and harmless medications, Vilprafen is known as an antibiotic belonging to the pharmacological group of macrolides, lincosamides and streptogramins. It is customary to appoint it in the fight against bacterial infections that are caused by sensitive microorganisms. An effective effect of the drug was noted in cases of respiratory and dental infections , lesions of the genitourinary system and infections of the skin soft integuments and tissues, gonorrhea and ureaplasmosis, chlamydia and syphilis, microplasmosis and similar infections. The analogue of "Vilprafen" - the drug "Clarithromycin" - is used only as an alternative.
pharmachologic effect
Wilprafen or in other words - Josamycin has a high activity against intracellular organisms, but along with erythromycin, the occurrence of resistance is not induced. A high concentration of the drug in foci of tissue damage has a clear bactericidal effect and has a negligible effect on enterobacteria. This means that the natural bacterial flora does not change in the stomach.
Kinetics of admission
Eating absolutely does not interfere with the bioavailability of the drug. therefore, it is easily and rapidly absorbed from the gastric tract into the circulatory system. Within a couple of hours after the use of the drug "Vilprafen" in serum, the maximum concentration is reached. Plasma proteins bind to the molecules of josamycin, the main active substance of this drug, and its concentration reaches 15%. A particularly high percentage is observed in the tonsils and lungs, sputum, lacrimal fluid. The drug can accumulate in bones, tissues and is secreted in breast milk after passing through the placental barrier. The metabolism of josamycin to weakly active metabolites occurs in the liver. Withdrawal occurs with bile. Excretion through the urethra is about 20%.
Josamycin - the main component of the drug "Vilprafen"
It is the fact that Josamycin is the sole substance of importance in the composition of the drug, the analogue of "Vilprafen" does not exist.
The main circumstance that worries people when buying Vilprafen is a rather expensive course of treatment that lasts longer than 10 days. To pass it in order to achieve a qualitative effect, you need to take pills completely and daily. With all the positive reviews about the drug, “Vilprafen” has a rather high price, and therefore people are constantly looking for an affordable analogue with the same qualities. Some experts recommend using the drug “Clarithromycin” as an analogue of “Vilprafen”, but only as an alternative.
To find an analogue of "Vilprafen" many are encouraged by the fact that its use is not forbidden to pregnant women, it can be used by breastfeeding mothers, and it is harmless to young children. With the known absence of embryotoxic effects, the drug "Vilprafen" is prescribed only by carefully assessing the risk or benefits of treatment.
The medicine "Vilprafen" and its combination with alcohol
The instructions attached to the drug do not contain instructions on the interaction of alcohol and the active substance josamycin. Wilprafen and alcohol are a bad combination. A sane person should not forget that alcohol has always had a harmful effect on the liver - the main organ that removes drugs from the body. It is thought that severe dysfunction of the liver will provoke an abnormal outflow of bile and alcohol intake is highly undesirable. The permissible daily norm can be only 200 milligrams of alcohol, and this, provided there is no increased activity of liver enzymes in the plasma.