Glycosylated hemoglobin and its physiological significance

The main criterion for the treatment of diabetes is the achievement of a stable physiological concentration of sugar (glucose) in the blood. Blood sugar control can be done at home using portable glucometers, as well as in the laboratory. From the individual results of a study of the concentration of glucose in the blood, it is impossible to judge the state of carbohydrate metabolism in the body. To date, a method has been developed for determining the amount of glycated hemoglobin, with the help of which it is possible to assess the state of carbohydrate metabolism. Numerous studies conducted by DCCT (Committee for the Control of Diabetes and Its Clinical Complications) have found that glucose levels are positively correlated with patient glycemia. Glycosylated hemoglobin is a qualitative indicator of the effectiveness of therapeutic treatment for diabetes mellitus.

Glycosylated hemoglobin is synthesized during the attachment of hexose to the nitrogen terminal sites of class A1 hemoglobin globin beta chains (HbA1c). The synthesized HbA1c is deposited in red blood cells (erythrocytes) and stored there for one hundred ten to one hundred thirty days (the lifespan of this cell). By this indicator, you can determine the level of glycemia in a patient 2-3 months before the start of the study.

Glycosylated hemoglobin and its concentration are directly proportional to the amount of glucose in the blood. How can I determine its level in the blood? To determine this indicator, it is best to use special test systems. You can also use other instrumental diagnostic methods: gas-liquid and affinity chromatography, electrophoresis, immunoelectrophoresis, etc. Glycosylated hemoglobin its norm for healthy people is from 4 to 6%. In patients with diabetes mellitus with hyperglycemia, glycosylated hemoglobin increases two to three times.

Hemoglobin in children is of particular importance, since in a growing body the metabolism is much higher compared to adults. Therefore, parents should know and control the level of hemoglobin in their baby’s blood. This is necessary to prevent iron deficiency anemia. The basis of the development of this disease is the deficiency of ferum in the body, which takes an active part in the synthesis of hemoglobin. Oxygen starvation adversely affects the development of the nervous, immune and cardiovascular systems. Children aged 9 months to 5 years are most susceptible to iron deficiency anemia.

Today, diabetes control is performed using the Accu-Chek 360 Β° mold. Thanks to this form, the attending physician records the level of glucose in the patient's blood on an empty stomach and after eating. The most effective way to lower your blood sugar is to use prolonged-acting insulin. The use of Accu-Chek 360 Β° promotes the proper selection of an insulin treatment regimen. Thus, we reduce blood sugar to a physiological norm. Many experts argue that through the use of this form of diabetes control, glycosylated hemoglobin levels can be effectively reduced to five to six units in a few months (physiological norm).

Therefore, if you have been diagnosed with diabetes mellitus, don’t despair, give up and get hung up on the thought that life is already over. You must fight for your health. People with diabetes need to constantly monitor the concentration of glucose in the blood. It is much more convenient to carry out these studies at home than to stand in the queues of the clinic. Using the modern form of Accu-Chek 360 Β° and glucometers, you can easily control your blood sugar.


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