Many indicators can affect the blood coagulation system, which are determined by a biochemical blood test and a coagulogram study, but in any case, remember that all indicators should be evaluated by a doctor and rely only on the evaluation of one indicator, but on the results of a comprehensive study. In some cases, to evaluate the coagulation and anticoagulation system of the blood, it is necessary to perform immunological tests, for example, donate blood for antibodies to cardiolipin and lupus anticoagulant.
What is lupus anticoagulant and its importance in the human body
Under normal conditions, the coagulation and anticoagulation systems of blood are in equilibrium - due to this, the fluidity of the blood vessels in the blood vessels is preserved in the absence of damage and the formation of a blood clot in injuries and wounds of any location. Accordingly, with an increase in the concentration of some substances in the blood serum, a compensatory increase in others should also occur - only in this case, the prevention of thrombosis is possible. But the human body can compensate for these changes only to a certain point, after which there comes a moment when even an existing tendency to thrombosis can cause bleeding - the factors responsible for blood coagulation simply will not remain in serum. The substances that can cause coagulation disorders include lupus anticoagulant - a special substance of protein nature, which relates to human immunoglobulins.
These antibodies are produced, as well as antibodies to cardiolipins and phospholipids in general, in the cells of the immune system and most often these substances are found in the blood in patients with various autoimmune diseases. But the problem also lies in the fact that the lupus anticoagulant, positive during pregnancy, can cause the development of various complications from both the pregnant woman and the fetus. It must be understood that the detection of lupus anticoagulant in the absence of antibodies to different DNA of the patient’s body, phospholipids, cardiolipin only indicates the possibility of developing these side effects and the need for constant medical monitoring of the patient.
It must be remembered that lupus anticoagulant, the norm of which with blood serum ranges from 0.8 to 1.2 conventional units, is not a sufficiently reliable indicator. Therefore, when identifying an elevated level or even a dubious result of a study, it is necessary to carry out a comprehensive coagulogram with the obligatory determination of D-dimer, coagulation time (APTT), and possibly a large number of study indicators - both the prognosis and the tactics of possible treatment of the patient depend on this.
Lupus anticoagulant - when research is needed
An immediate blood test for lupus anticoagulant may be required not only for pregnant women. This analysis is prescribed and performed for patients who, up to the age of 40, have arterial and venous thromboses of any localization, thromboembolism, sudden hemorrhagic or ischemic strokes without the presence of diseases in which cerebrovascular accident (arterial hypertension, atherosclerotic cardiosclerosis) may develop . Particularly noteworthy are young women who, during their lifetime, have had cases of sudden fetal death at any stage of pregnancy in the absence of genetic diseases and intrauterine infection. Only with constant monitoring of coagulogram, lupus coagulum, antibodies to phospholipids and cardiolipin can an effective treatment be selected - only in this case can the progression of coagulation disorders be prevented.