It's no secret that over the past century, the number of patients with various forms of allergies has increased several times. Urticaria, Quincke's edema, hay fever, atypical dermatitis and others. Their list can still be continued. But all of them will be united by one thing - these are all different types of allergies, due to the excessive sensitivity of the immune system. And it is largely the result of the progress of the last hundred years.
At the heart of any allergic process is two groups of reactions. The first is contact with an allergen. And only with that to which the immune system is especially sensitive. And the second is the reaction to this contact. It manifests itself in the release of a huge amount of substances from special cells (bradykinin, histamine, etc.). These substances actually cause allergic reactions. But besides this, they act on such cells, forcing them to produce the same substances. As a result, a whole cascade of reactions develops. And it will go until all cells stop producing these substances, called allergy mediators.
From the time that allergy mechanisms have been identified to this day, antihistamines have been used in medicine . Now there are several dozen and three generations of them. This is due to the fact that earlier drugs have a sufficient number of side effects. And their use in many cases makes people give up certain activities.
Among the second-generation drugs, citrine is especially prominent. The medicine has the ability to bind to histamine receptors for a long time, without exciting them. That is, citrine - a medicine that blocks these receptors and histamine can no longer realize its effects. Its main advantage, compared with first-generation drugs, is the minimal effect on the brain. Thus, citrine tablets practically do not cause drowsiness. In addition, the action time is very long - almost 24 hours. Therefore, citrine is taken 1 time per day.
According to the main indicators of metabolism, citrine is a medicine that has very good characteristics. It has great accessibility. This means that when you use one tablet of citrine, almost all the medicine in an hour will be in the blood. Most of it binds to blood proteins and is slowly released from them. Thus, providing a constant level of concentration. In addition, there is another feature that citrine has. The medicine is excreted from the body, basically, without changes, with the help of the kidneys. Only a small part of it is inactivated in the liver. While most of the other drugs are metabolized by the liver.
Citrine is available in film-coated tablets. One contains 10 milligrams of citrine and about 500 milligrams of excipients. In addition, there is syrup. It is intended for children from two years. This fact is very remarkable, since for many drugs the minimum allowable age is 6 years. And atypical dermatitis affects children at any age. Therefore, for children with atypical dermatitis and diathesis, citrine syrup is shown, a medicine that is in a form convenient for them.
When taken in therapeutic doses, 1 tablet 1 time per day, the medicine in the blood has a constant concentration. The course is 7-10 days. Moreover, the force of action does not decrease over time, since citrine does not cause tolerance - a gradual decrease in sensitivity to the drug. Which is the case with most other antihistamines. The effect itself persists for 3 days after taking the last pill.
Side effects are practically no different from all antihistamines. But usually they are less pronounced and often not recorded. Among them: nausea, headache, drowsiness.