It happens that it is problematic not to conceive a baby, but to endure it, that is, the egg is fertilized, but there are reasons why a happy outcome in pregnancy is impossible. Miscarriages occur mainly in the early stages of pregnancy, when only two strips of dough testify to the emerging baby. Genetic incompatibility of spouses is one of the reasons for miscarriage. In this case, when planning a pregnancy, you need to contact not only the gynecologist, but also consult a geneticist. He will help you do everything you can to become happy parents. Unfortunately, couples rarely do genetic testing at an early stage of pregnancy planning. Genetics are most often consulted by spouses who have undergone a standard medical examination. The health confirmed by the analyzes, however, does not allow, for some reason, to conceive or bear a baby.
What is the genetic incompatibility of the spouses?
The protein found on the surface of all cells in the human body is called HLA. The abbreviation stands for human leukocyte antigen. These proteins are a kind of "guard" of the body. They recognize the "pests" (bacteria, cancer cells, viruses), and then send a signal to produce antibodies for their destruction.
Pregnancy is also regarded by proteins as an “enemy." Half of the proteins in the embryo are paternal and the other half are maternal. For this reason, the mother’s body begins to produce antigens that protect the placenta.
With the great similarity of parental HLA, the mother’s body takes “strangers” for “their own”. As a result, the placenta and the baby are not protected. The female body takes pregnancy for danger and begins to reject the fetus. The greater the similarity of the parental chromosomes, the higher the risk of miscarriage. And, accordingly, the more parental HLAs differ, the less is the risk that there will be incompatibility of the spouses.
A compatibility analysis takes about two weeks. Pure DNA is isolated from the venous blood of both parents using reagents. Then its in-depth analysis is carried out, and only then is a comparative study conducted. Genetic incompatibility of spouses already occurs with two identical HLA proteins. Only highly qualified genetics can decipher the test results. He will make a conclusion.
Complete incompatibility of spouses is a rare occurrence. In most cases, partial incompatibility is recorded. There is a possibility of its regulation during planning, conception and the period of pregnancy. Under the supervision of an experienced geneticist, you can become pregnant, endure and have a baby safely.
Doctors use medications in the treatment. Therapy can be carried out in both spouses or only in the mother. It depends on the degree of incompatibility.
There is also an immunological incompatibility between spouses. This phenomenon has something in common with Rh incompatibility. Parent cells contradict each other in their immunological properties. Previously, this was treated by sewing a flap of a man’s skin onto a woman’s body. Modern medicine uses centrifugation of a man’s blood serum , separation of the lymphocyte fraction and immunization with this serum of the female body.
Sexual incompatibility of spouses can be real and fictitious. In the first case, the basis is real facts, in the second - sexual illiteracy and lack of desire to work on relationships. The couple should contact a sexologist to solve the problem.