Modern medical practice is improving every year, which is why there is a need for the introduction of new terms. In our article, we will examine what the additive effect is and “what it is eaten with”.
In the world of living organisms - from bacteria to mammals - two main types of interaction between individuals are common: synergism and antagonism. Synergy is a joint activity that is beneficial to all participants in the relationship. With antagonism, the action of one or a group of organisms adversely affects another group. Based on these observations, scientists came to this conclusion: similar models of relationships can be applied in medicine. Synergism-based drug therapy is called the “additive model.” She was in demand in medicine. The effect of drugs based on synergism is called the "additive effect". So, let's take a closer look.
In medicine, the above concepts can be considered from two points of view: pharmacology and biology, but the essence remains unchanged.
The additive effect of drugs is a type of synergy in which the sum of the effects of several substances used simultaneously is equal to the sum of the effects of each substance individually. Simply put, one medicine has a positive effect on another.
An additive model is one in which the effect of the sum of drugs is equal to the effect of each drug separately (with the exception of the effect of other drugs). As an example, consider two drugs. When they act separately, despite the positive effect, each has its own side effect. However, if the drugs are used together, one medicine will enhance the effect of another and, as a result, the side effect of one of the medicines will either disappear or be weakened.
Drug synergism can be expressed not only as an additive effect, but also as potentiation, that is, the effect of combined substances exceeds the sum of the effects of individual drugs.
In addition, direct and indirect synergies are distinguished, direct - drugs have one point of application, indirect - when drugs have a different point of application and affect indirectly the effect of each other.
The additive method of drug therapy is widespread in modern medical practice, for example, with the introduction of non-narcotic analgesics. Other synergies have also found their application. For example, potentiation is used when administering chlorpromazine and anesthesia drugs. Aminazine, having a potentiating effect on medicines for anesthesia, can reduce their dosage. Indirect and indirect types of synergism are used to treat diabetes and asthma.
The additive effect with proper use can be an excellent assistant in the treatment of a large number of various diseases. At the same time, it will help to cure even those diseases that are difficult to treat with standard methods. But it is worth remembering that the use of a large number of different drugs can lead to disastrous consequences, so you should always consult a doctor.