But shpa (or drotaverine) belongs to the group of antispasmodic drugs. The effect of the drug extends to muscle tissue and develops as a result of a decrease in the amount of calcium supplied to the muscles. This in turn causes inhibition of phosphodiesterase and the accumulation of cyclic adenosine monophosphate.
As a result, but shpa weakens the tone of the muscular system (in particular, smooth muscles) and gastrointestinal motility. In addition, but shpa causes vasodilation without affecting the autonomic and central nervous system. This feature allowed the use of the drug in cases where antispasmodics of central action (that is, acting on the central nervous system) are contraindicated.
With intravenous administration, the effect begins to develop in two to three minutes, its maximum severity falls on the time interval - "half an hour after administration of the drug."
But shpa is available in the form of injectable solutions, tablets, capsules, and coated tablets.
As an antispasmodic, but shpa has found application in the following conditions: gastroduodenitis, spasm of the muscular system of internal organs (with biliary, renal and intestinal colic, with dyskinesia of the gallbladder and excretory tract, with cholecystitis), spastic constipation, pyelitis, peptic ulcer.
In addition, but shpa is used for spasm of peripheral, as well as coronary and cerebral arteries. This explains the effectiveness of spas for headaches of a spastic nature. This medical product has found its application in obstetrics and gynecology. It is used when there is a threat of miscarriage, premature birth, algodismenorea, spasm of the uterus and prolonged opening of it during childbirth, as well as for the relief of postpartum contractions.
But Shpa is also used in some diagnostic procedures, for example, with cholecystocholangiography.
With the use of any drugs, side effects and reactions may develop. So, when applying but shpahs are possible: palpitations, dizziness, sensation of heat, a decrease in blood pressure, as well as various allergic reactions. When using the drug intravenously (that is, with the injection method of administration), the development of collapse, arrhythmia, atrioventricular blockade, as well as depression of the respiratory center, is possible.
But spa: overdose of the drug. It manifests itself in most cases as a violation of atrioventricular conduction, a decrease in the excitability of the heart muscle, which ultimately can lead to cardiac arrest or paralysis of the respiratory center.
There are a number of contraindications to the use of this antispasmodic. With renal, hepatic or heart failure; with atrioventricular blockade of the second or third degree of severity, with arterial hypotension and cardiogenic shock. Shpu is also not used for significant coronary arteriosclerosis, prostatic hyperplasia and angle-closure glaucoma, during lactation and in the first trimester of pregnancy.
So how to take noshpu correctly? Firstly, it is necessary to choose the right dosage of the drug depending on the pathology. The most acceptable dosages are: when administered orally, for adults, from forty to eighty mg three times a day; with intramuscular or subcutaneous administration, the dosage is the same, the frequency is from one to three times a day. In order to stop an attack of renal, hepatic, or other colic, but the spa is administered intravenously in an amount of 40-80 milligrams. Perhaps intra-arterial administration of the drug, in particular with spasm of peripheral vessels.
The dosage of the drug (single, single dose) for children under six years old ranges from ten to twenty mg, the daily dose (maximum for a given age) is 120 mg; at the age of six to twelve years, a single dose is 20 mg, a daily dose of two hundred mg. In childhood, the drug is used with a multiplicity of up to two times a day.