Pain is a protective reaction of the body and a signal to a person that inside, most likely, something went wrong. But sometimes it is unbearable to endure, and besides, often this is not necessary. There are many modern drugs that allow you to quickly stop pain attacks. One of them is Ibuprofen (400 mg), the instructions for use of which recommend taking it to relieve unpleasant sensations in a variety of diseases.
general information
There is a large class of drugs that relate to non-steroidal anti-inflammatory drugs. They eliminate pain and have an antipyretic effect. Also, these drugs reduce the severity of the inflammatory process, and the effect of them is quite fast. One such drug is Ibuprofen (400 mg). The instruction for use recommends taking it for pains of various nature and elevated body temperature.
The tool refers to high-speed drugs that relieve symptoms, but, unfortunately, do not eliminate the causes of the disease. Therefore, most often "Ibuprofen" is part of the complex treatment of various diseases. It allows a person to transfer the healing process much easier due to the fact that the clinical picture against the background of his intake becomes less pronounced. In parallel with it, etiotropic treatment is prescribed, that is, one that affects the true nature of the disease.
Release forms and composition
The first thing that catches your eye when you open the package of Ibuprofen medicine (400 mg) is the instructions for use. The composition of the drug is as follows:
- active substance - ibuprofen;
- additional components (may vary depending on the manufacturer) - silicon dioxide, corn starch, magnesium stearate, titanium dioxide, talc, sodium carboxymethyl starch, povidone K30, macrogol 4000, hypromellose, microcrystalline cellulose.
Each tablet has a special feature, which makes it possible to divide the medicine into 2 equal halves. This is very convenient in cases where you need to simultaneously take, say, 200 or 600 mg of ibuprofen.
Non-steroidal anti-inflammatory drugs with prolonged use, unfortunately, adversely affect the mucous membrane of the digestive system, this also applies to the drug "Ibuprofen". The instruction for the use of tablets (400 mg) recommends taking after meals so that the stomach does not succumb to the irritating effect of the drug.
The mechanism of action of the drug
During inflammation, prostaglandins (physiologically active substances) are actively formed in the tissues, an increased level of which brings a person pain. The reaction of their synthesis is accelerated by the enzymes cyclooxygenases of the 1st and 2nd type (COX-1 and COX-2).
Nonsteroidal anti-inflammatory drugs inhibit the formation of these catalysts, and the number of prostaglandins is rapidly decreasing, since the reaction is not so intense. This mechanism of action has Ibuprofen (400 mg). Instructions for use, a description of the drug in pharmaceutical handbooks indicate that the product effectively eliminates pain, relieves inflammation and lowers overall body temperature. The maximum concentration of the active substance is observed 1-2 hours after taking the pill inside. The drug is excreted from the body mainly with urine, and accumulates in the body in plasma and periarticular fluid.
The advantage of tablets over other dosage forms
Ibuprofen is available in different doses and dosage forms. It is presented in syrups, tablets, suspensions and capsules. But if we consider "Ibuprofen" (400 mg), the instruction for use of which involves oral administration, then at this dosage it is available only in tablets. This type of medicine has certain advantages:
- convenience of reception;
- the absence of an unpleasant aftertaste of the active substance due to the shell and additional components;
- persistent effect;
- exact dosage.
The use of tablets does not require the participation of medical personnel (as is the case with injections, for example) and the observance of sterility conditions. Ibuprofen tablets are medium in size, it is convenient to swallow them with a small amount of water.
Indications for use
The most comprehensive document that describes the indications for the use of the drug "Ibuprofen" is the instructions for use. Tablets (400 mg) are usually prescribed to the patient with the following symptoms and diseases:
- migraine;
- painful menstruation;
- inflammation and pinched nerves;
- fever;
- toothache;
- stiffness and discomfort in the joints with arthritis, arthrosis and non-rheumatic inflammation;
- muscle pain
- ligament inflammation;
- rheumatoid processes;
- inflammation of the uterus;
- Ankylosing spondylitis;
- manifestations of acute respiratory viral infections, tonsillitis, bronchitis.
The tool can be used as part of complex therapy in patients with nephrotic syndrome. It reduces the amount of protein in the urine and reduces the intensity of pain. The medicine helps to reduce discomfort in the postoperative period, although it can not be the only analgesic in this case.
"Ibuprofen" (400 mg): instructions for use, analogues of the drug
Tablets with this dosage are available under the following trade names:
- MIG-400.
- "Nurofen Forte."
- Faspik.
- "Brufen."
- Burana.
- Ibuprom Max.
- Ibuprofen Nycomed.
There is also a high-quality domestic drug "Ibuprofen Hemofarm" (400 mg). Instructions for use suggest its use according to this scheme:
- for pain of moderate severity - 1 tablet 3 times a day;
- with rheumatoid inflammation of the joints - 2 tablets three times a day;
- with muscle pain and diseases of the ligaments - 1.5 tablets 2-3 times a day;
- with ankylosing spondylitis - 1-1.5 tablets up to 4 times a day.
These recommendations are standard for taking ibuprofen tablets at a dose of 400 mg by any manufacturer. To reduce the temperature, the amount of the drug is calculated based on the weight of the patient. If the mark on the thermometer reaches 39.2, you need to drink the drug from the ratio of 10 mg / kg of a person’s weight (if the value is less, then 5 mg / kg of the patient’s body weight is enough).
Contraindications
Not all people can safely use Ibuprofen tablets (400 mg). Instructions for use of contraindications indicate the following:
- digestive ulcers;
- gastritis and chronic inflammation of the intestine during periods of exacerbation;
- bronchial asthma;
- severe violations of liver function (for example, cirrhosis or deep lesions of the blood vessels of this organ);
- age up to 12 years;
- last trimester of pregnancy;
- high blood pressure;
- swelling
- diseases of the optic nerves;
- disorders of color perception due to ophthalmic diseases;
- individual intolerance to the components of the drug;
- heart failure;
- poor blood coagulation.
With lactation, ibuprofen passes into breast milk, but in very low doses. To cancel the natural feeding of the newborn due to the appointment of this drug to the mother, is necessary only in those cases when the woman has long-term drug therapy.
What is dangerous overdose
Before treatment, it is advisable to find out such information about Ibuprofen (400 mg): instructions for use, release form and contraindications. But it is important to read about safe doses of the medicine, because exceeding them can lead to sad consequences. Between doses, it is important to maintain a minimum interval of 6 hours, more often you should not drink these pills because of the high risk of side effects on the body. In any case, the daily dose of the drug should not exceed 2.4 g.
Symptoms of taking excessive amounts of medication:
- nausea (vomiting is sometimes possible);
- headache;
- impaired vision;
- lowering blood pressure;
- abdominal pain;
- dizziness;
- labored breathing;
- blue skin.
There is no specific counteracting agent, so if alarming symptoms occur, the patient needs to rinse his stomach, provide fresh air and immediately call an ambulance.
Compatibility with other medicines
Not all drugs are compatible with each other. They can enhance each other's side effects or weaken their effectiveness. In this regard, the drug “Ibuprofen” (400 mg) is no exception. Instructions for use warns that the medicine can not be taken with such medications:
- drugs for the treatment of hypertension (it reduces their activity and can cause an increase in blood pressure);
- "Furosemide" and diuretics similar in action (ibuprofen impedes their action);
- antitumor drugs (since ibuprofen enhances their toxic effect on the body).
During treatment with the drug, you should not drink alcohol, since this combination leads to the undesirable side effect of Ibuprofen and enhances the harmful effects of alcohol.
Doctors reviews
Doctors say that ibuprofen is one of the safest representatives of non-steroidal anti-inflammatory drugs. On its basis, a huge number of OTC drugs with a high efficiency are produced. Doctors noticed that those patients who took into account all contraindications and did not exceed the recommended dosages, only benefited from taking the medicine.
Reviews of experts suggest that the medicine can quickly relieve pain in neurological and orthopedic diseases. And although it does not remove the cause of their appearance, it nevertheless greatly facilitates the condition of the patient. When the pain subsides, the person improves his mood, and he calms down, and, according to doctors, the outcome of treatment depends on psychological comfort by half.
Patient Reviews
Patients who took this drug are mostly satisfied with the speed of its action and the relatively low price. Tablets well stop attacks of headache and joint pain, effectively relieve fever. Many patients with arthritis noticed that by drinking a pill in the morning, they could calmly move without pain at least until noon.
Patients with acute diseases of the ENT organs (most often it was a sore throat) were pleased with the analgesic effect of Ibuprofen. Thanks to these pills, they could swallow food and drink liquid without terrible discomfort and pain. True, in order to maintain a lasting effect, they had to take the drug 2-3 times a day.
The opinions of those who are often tormented by headaches are divided. Some of them say that the medicine quickly and permanently eliminates pain and for this it is enough to take 0.5-1 tablet. But patients with severe migraines who have previously taken prescription drugs claim that the effect is not always as pronounced as necessary.
Ibuprofen (400 mg): instructions for use, description of shelf life and storage conditions
One of the advantages of tablets is a long shelf life, regardless of whether the packaging is opened or sealed. This is also true for Ibuprofen (400 mg). Instructions for use provide a shelf life of the drug up to 3 years at room temperature in a dry place. The medicine should be stored in a place protected from children, in order to avoid accidentally swallowing tablets.
Normally, ibuprofen tablets are of the same shade and have smooth edges. If some of them differ in color from that which was originally at the opening of the package, you can not use the drug. It could oxidize or deteriorate, so its use is unlikely to be useful, but the chance of an unpleasant effect on the body is very high. It is undesirable to store the medicine in the kitchen or in the bathroom (due to increased humidity and temperature).
Pediatric Use
The first thing you need to pay attention to before using the Ibuprofen agent (400 mg) in childhood is the instructions for use. The dosage for the child is significantly different from that recommended by adults. Up to 12 years, the drug is not used in principle, since there are special “children's” forms of drugs with ibuprofen (suppositories, suspensions, syrups).
On average, a child may be recommended to take the drug 100-300 mg 3 times a day. The permissible maximum daily dose for children is 1 g. The frequency of admission should always be determined by a doctor who is aware of the diagnosis and condition of the child. For children, this drug is most often prescribed for the treatment of teenage arthritis, rheumatism and in order to lower body temperature.
Is it possible to use the drug during pregnancy
For ethical reasons, most drugs never undergo clinical trials (i.e. human trials) during a woman's pregnancy. Therefore, data on theoretical harm or its absence are either entirely empirical or based on the results of experiments with animals. It is still not known exactly how a drug such as Ibuprofen (400 mg) can affect a pregnant woman. Instructions for use indicate data according to which, it definitely does not need to be used in the last 3 months of pregnancy.
But even at the initial stages of bearing the fetus, the ratio of risk and benefit of the remedy should be decided by the woman's doctor. Given that during this period there is a laying and development of all the organs of the unborn baby, it is not necessary to use this tool without special indications.
Additional recommendations
The drug is undesirable to take more than 4 days in a row. If symptoms intensify or do not subside, it is necessary to consult a doctor to correct the prescribed therapy. In general, the medicine is well tolerated, but it is better for older people to start treatment with "Ibuprofen" in minimum dosages, reducing the total duration of the course.
With pain, many people do not go to the doctor, but begin to seek treatment options on their own. Now in the pharmacy there are a lot of effective drugs that everyone is hearing, among them is the Ibuprofen medicine (400 mg). Instructions for use, reviews are such information that you can easily find on your own or find out through friends, but it is extremely dangerous to self-medicate. It is much better to consult a doctor to be sure that a person can take the drug, and he does not have any (sometimes not always obvious) contraindications.