Skin problems worry many people. They not only spoil the appearance of a person, but can also lead to more serious diseases and complications. To combat them effectively, you need to find the right medicine. Remedies for acne on the face are not equally effective for everyone. Only an examination by a dermatologist will help you choose the right treatment.
"Tretinoin" from acne has already helped many. This tool has the necessary properties that can cope with skin lesions. Before you start using the drug, you should consult with a specialist about possible negative consequences and consider in detail the effect of Tretinoin, release forms and analogues.
Tretinoin Release Forms
Remedies for acne on the face are of several types. Many of them are released under the same name, which helps to choose the most convenient tool to use. Not an exception and "Tretinoin". The price of the drug may also depend on its form.
"Tretinoin" is available in the form of a cream, lotion, gel, solution and capsules. "Tretinoin" lotion is designed to cleanse the skin from impurities, relieve inflammatory processes and get rid of acne and other types of acne. This form is ideal for young skin care, normalizes the sebaceous glands, which helps to get rid of oily sheen.
Tretinoin cream is more suitable for older people with signs of skin aging. The cream has a greasy base, which helps smooth out age wrinkles. This cream is an anti-inflammatory that effectively fights most skin and subcutaneous tissue problems.
The gel has a lighter structure in comparison with the cream and is suitable for oily and combination skin types. Like cream, it has an anti-seborrheic effect. Tretinoin capsules are used to induce remission in acute promyelocytic leukemia and should be prescribed only after an accurate diagnosis has been made. Treatment with Tretinoin capsules should be supervised by an oncologist and hematologist.
The solution has the same pharmacological effect as cream and lotion. It is used not only to solve visible skin problems, but can also draw hidden acne. It is used as part of the complex treatment of various types of acne.
The composition of the drug
"Tretinoin" cream contains in its composition the active substance - transretinic acid (tretinoin) in the amount of 0.05% or 0.1%. The higher the mass fraction of the active substance, the more effective the effect of the drug. Tretinoin is a powdery substance of a yellow or light orange hue, therefore, in the cream there are auxiliary products that create a water-oil and oil-water base.
Gel "Tretinoin" contains in its composition the active substance in an amount of 0.1%, 0.025% or 0.05% of the total mass. In addition to tretinoin, the gel also contains propylene glycol, carbomer, isopropyl alcohol, triethanolamine, butylated hydroxytoluene and some other substances in small quantities.
"Tretinoin" lotion with zinc is available with a concentration of the active substance of 0.05%, and a solution with 0.1%. Also in the composition of the lotion are propylene glycol and ethyl alcohol, which have a bactericidal effect.
Each Tretinoin capsule contains 10 mg of the active substance and excipients such as beeswax and soybean oil. The gelatin shell of the capsule contains glycerol, karyon-83, titanium dioxide and dyes.
Indications for use
The drug belongs to the group of retinoids, in structure close to vitamin A. Obtained from the metabolism of retinol. Tretinoin has antiseborrheic, antitumor, keratolytic and comedonolytic effects. In addition, it stimulates tissue regeneration, strengthens the immune system, and also has a local anti-inflammatory effect. It is used to treat draining and vulgar acne. In the form of capsules, the drug is effectively used for the processes of remission of myeloid leukemia.
"Tretinoin" cream is used to suppress skin inflammatory processes and has a general beneficial effect on the upper layer of the epidermis. It can be used to treat certain types of dermatitis and other skin diseases.
Action taken
"Tretinoin" cream (for acne) allows you to remove inflammatory processes in different layers of the epidermis, applied externally, but has a deeper effect. The active substance affects the formation of elastin by the skin cells, which increases skin elasticity and helps to reduce the appearance of wrinkles and other age-related changes.
Tretinoin affects the production of melanin, inhibiting the process of its formation in large quantities, which reduces the risk of malignant tumors. It also stimulates the growth of epithelial cells and activates the processes of their division, which contributes to the restoration of the skin.
When treating open acne, the product evens the upper layer of the epidermis without leaving scars and other signs of tissue damage. On closed acne, the drug has a pulling effect, which leads to their discovery and further removal, while reducing inflammatory processes and preventing scarring of tissues. Also discourages new acne rashes.
The anti-seborrheic effect of the Tretinoin-cream preparation is to prevent the growth of epithelial cells, normalize the functioning of the sebaceous glands, and reduce inflammatory processes at the locations of the sebaceous ducts.
The effect of using the drug appears after a half to two months. After one to two weeks of use, an increase in the number of blackheads may be observed. This occurs in the process of exposing and opening hidden eels.
Tretinoin capsules are intended for oral use. They are prescribed only to those patients who have an abnormal level of formation and accumulation of promyelocytes, which leads to myeloid leukemia. Tretinoin inhibits the accumulation of myeloid cells, which leads to remission, which can last from two to four months.
Contraindications
Sensitivity to the active substance of the drug is sufficient reason for the inability to use it. You can also not use "Tretinoin" during pregnancy, as this can lead to impaired development of the embryo. During breastfeeding, you can also not use the drug orally.
The drug is not prescribed for patients with acute inflammatory processes on the skin, the presence of skin lesions in the form of wounds or burns. It is also unacceptable to prescribe the drug to patients with cutaneous epithelioma or having a family predisposition to it. You can not use the drug for various types of eczema, pancreatitis, diabetes mellitus and increased intracranial pressure.
The drug has age restrictions. It is not prescribed orally to children under the age of one year, externally up to twelve years, and in any form to patients over fifty years of age.
Side effects
When taking the drug, “retienic acid syndrome” may develop orally, which can lead to serious consequences.
When the first symptoms appear, it is necessary to immediately prescribe the appropriate treatment. Symptoms of the syndrome are shortness of breath, hyperleukocytosis, hypotension, fever, renal and hepatic multiple organ failure.
When using forms of "Tretinoin" for external use, various skin reactions (peeling and dryness), rashes, itching, subcutaneous hemorrhages can be observed. Reactions such as dry mouth, increased sweating, sensitivity to ultraviolet rays, alopecia, hyper- and hypopigmentation can also occur.
In some cases, there are violations in the digestive tract (nausea, vomiting, diarrhea), the central nervous system (depression, dizziness, hearing and vision disorders, increased intracranial pressure).
Violations in metabolic processes due to the use of the drug are expressed in changes in body weight and the appearance of cellulite, as evidenced by reviews. "Tretinoin" can also lead to respiratory infections, accompanied by cough, shortness of breath, swelling of the mucous membrane and larynx, wheezing in the lungs.
In some patients, after taking the drug, arrhythmia, pain in the muscles, chest and back, general weakness of the body and drowsiness were observed. With the development of several side effects at once or the appearance of a threat of complications from taking the drug, the patient may be given a complete refusal of treatment or a decrease in the initially recommended dosages. There is a possibility of replacing Tretinoin with analogues.
Instructions for use
Tretinoin (cream or gel) should be applied in a thin layer with rubbing movements only on the affected skin once a day and left for six hours. After this time, it is recommended to rinse the drug with water. It should be remembered that exceeding the dose will not lead to a faster result.
Owners of fair skin or dry skin are recommended to start leaving the drug for only half an hour. With a normal skin reaction, time can be gradually increased. It is allowed to remove ripened pustules and comedones during treatment. The course of treatment varies from two weeks to three months and depends on the degree of skin damage and the susceptibility of the body to treatment.
The daily dose of the Tretinoin preparation in capsules should not exceed 45 mg per square meter of skin. The course of treatment is three months. The dosage is the same for all ages not indicated in contraindications. When diagnosing a patient with kidney or liver failure, the dose should be reduced to 25 mg.
The maximum allowable daily dose for an adult is 195 mg of the drug per square meter of skin and 60 mg for a child. With extensive tumors, the daily dose can be increased to a third of the maximum allowable.
When using drugs containing tretinoin, avoid prolonged exposure to direct sunlight. In case of observing a tan, the patient should postpone treatment until the skin is naturally lightened.
Drug Interactions
Medicines that affect the activity of the production of liver enzymes significantly reduce the effectiveness of the Tretinoin Retin A preparation. Glucocorticosteroids, rifampicin, pentobarbetal and phenobarbital are stimulants for the production of liver enzyme activity. Suppress the activity of the liver enzymes Verapamil, Erythromycin, Ketoconazole and others. Experts say that Tretinoin does not affect the effectiveness of these drugs, as evidenced by studies and their reviews. Tretinoin reduces the effectiveness of contraceptives in tablets based on progesterone (miles drank).
Caution should be exercised with the simultaneous use of Tretinoin and the use of antifibrinolytic agents, as some patients had thrombotic complications with a fatal outcome.
A feature of the action of the "Tretinoid" is a possible increase in intracranial pressure. The same effect is observed in tetracycline drugs, so you should not use these drugs at the same time.
Tretinoin: analogues
To solve skin problems, there are several similar tools that also do a good job. "Tretinoin", the price of which is quite high, for some reason may not be suitable (individual sensitivity and other contraindications) for a particular person.
"Retinoic ointment" is a cheaper analogue of "Tretinoin" and in its composition has vitamin A and isotretinoin. If you use the ointment incorrectly and do not follow the instructions, you can get a skin burn. Initially, the drug was intended to combat acne and other rashes, but during use it turned out that the ointment, when exposed for a short time, activates the production of collagen and thereby smoothes shallow wrinkles.
"Differin" in its composition has the active substance adaptale, which is a synthetically derived analogue of retinoic acid. It has a milder effect compared to Tretinoin. Also available in gel form for oily skin and as a cream for dry skin type. The drug is not intended to get rid of neoplasms and seborrheic dermatitis. The presence of these diseases is a contraindication to the use of "Differin", as it requires more powerful means.
Drug price
Tretinoin cream, the price of which depends on the form of the drug and its manufacturer, is popular enough to solve skin problems. Generic drugs are delivered to Russia. This is evidenced by numerous reviews. Italian-made Tretinoin in the form of a cream or lotion with zinc is called Ayrol. It has a more affordable cost compared to other manufacturers, an average of 2500 rubles per 50 ml of lotion or 30 mg of cream.
Lokatsid is a cream containing tretinoin, the price of which is only 1,500 rubles. Under this name, you can also find a solution for external use with tretinoin. But, according to patients, it has a less effective effect or requires more cream.
Under the name "Retin-A" you can find the "Tretinoin" -oil and gel made in India. "Vesanoid" - Swiss-made tretinoin capsules. Their cost per pack is 100 pcs. is more than 10,000 rubles, but one package is enough to undergo a course of therapy.
Application Reviews
Tretinoin is considered one of the best solutions to get rid of many skin problems. In the absence of contraindications, you can count on an excellent result and smooth skin after just a few weeks of using the drug. The tool may not be recommended by specialists because of a wide range of side effects and contraindications, as evidenced by numerous reviews. Tretinoin should only be used under medical supervision. Self-administration can be fraught with consequences.
"Tretinoin" from wrinkles also has its contraindications to use, unlike cosmetics, it can not be used without consulting a specialist who will select the optimal dosage and duration of use.
Those patients who used the drug to get rid of acne and acne note its beneficial effect on the skin of the face and body. Patients indicate a healthier skin after a couple of weeks after starting to use the product. A long-lasting effect was also noted, which allows you to rarely use the drug and minimize side effects of the drug. Compared with other similar products, Tretinoin has a fairly quick effect and allows you to quickly get rid of the problem or make its manifestations less noticeable.
Many other products that can be purchased at the pharmacy are designed to get rid of acne, wrinkles and solve various skin problems. They are much easier to buy, since they cost much less, but they do not have the same effect as Tretinoin. This drug has established itself as one of the best in the fight against skin problems.