In the instructions for use with Flemoxin Solutab, the manufacturer indicates that the drug is based on amoxicillin. The product is commercially available in tablet form. The drug is intended for dissolution in water. Belongs to the group of antimicrobial agents, has a pronounced antibiotic effect. It is used strictly according to the doctor’s prescription. Improper and unreasonable use can harm the patient, since Flemoxin Solutab has a number of contraindications, and in some patients it provokes side effects.
General information
There are several dosage options available. The amount of active substance per tablet is indicated in the instructions for use. Flemoxin Solutab may contain from 125 mg to 1 g of the active compound. The antimicrobial substance is presented in the form of a trihydrate. Additionally, the manufacturer used auxiliary substances that provide the medication with a long shelf life. Due to such additives, it is quite convenient to use the drug.
The instructions for use of Flemoxin Solutab indicate that each capsule contains cellulose, aromatic additives, saccharin, crospovidone, magnesium stearate. This set of substances ensures the solubility of the drug in pure water.
What's in the package
In the instructions for use of Flemoxin Solutab, the manufacturer describes how the drug should look. Normally, these are tablets of white color or painted in a light shade of yellow. The medication is made in the form of an oval. On the one hand, numbers reflecting the amount of active compound in the capsule are engraved, on the other hand, the manufacturer’s logo. There is a risk for the convenience of dividing the dose into two parts.
Pharmacology and Kinetics
The instructions for use of Flemoxin Solutab 1000 mg and other dosage options indicate that the drug is based on amoxicillin. This allows us to rank it among the penicillin series, medicines, which are characterized by a wide range of effectiveness. Antibacterial substance belong to the group of beta-lactam. Designed for systemic use.
Absorption of the active component occurs almost immediately after the tablet is ingested. In the instructions for use "Flemoxin Solutab" 250 mg (and other options for release), the manufacturer indicates that absorbability reaches 93%. The substance is resistant to acids.
The highest levels of concentration in the circulatory system are achievable in an hour or two after using the substance. If you use (following the instructions for use) a tablet of Flemoxin Solutab 500 mg, amoxicillin in the patient's blood is determined in a concentration close to 5 μg / ml. These indicators are achievable by the end of the second hour after using the substance. If the dose is increased / decreased by half, the concentration of amoxicillin in the blood plasma is proportionally changed.
What happens in the body
In the instructions for use for Flemoxin Solutab tablets, the manufacturer pays attention to the interaction with plasma proteins of approximately 20% of all amoxicillin ingested by the patient. The substance easily penetrates into the mucous membranes and tissues of the skeletal system, the fluid of the visual organs and sputum produced in the respiratory system. Achievable concentrations showing a pronounced therapeutic effect. In bile, the content of amoxicillin is twice as high as in the blood plasma.
In the vessels of the umbilical cord and amniotic substance, as follows from the instructions for use "Flemoxin Solutab" 500 mg and other forms of release, the concentration of amoxicillin is lower than in the circulatory system of a pregnant woman.
Tests have shown that amoxicillin hardly seeps through the blood-brain barrier. It was also found that the use of the drug in inflammatory processes in the membranes of the brain is accompanied by the accumulation of amoxicillin in the fluid of the spinal cord. On average, indicators make up 20% of the norms characteristic of the circulatory system.
Recycling and elimination
In the instructions for use "Flemoxin Solutab" 125, 250, 500, 1000 mg, the manufacturer indicates that metabolic processes mainly occur in the liver. Processing products in their bulk do not have pharmacological activity.
Excretion of the main percentage of amoxicillin is carried out by the kidneys. About 80% is excretion along the tubules, other volumes are glomerular filtration. If the functionality of the kidneys is normal, the half-life of the active component varies within an hour and a half. According to the instructions for use "Flemoxin Solutab" 125 mg (or other release format), if the drug is used to treat young children (under six months of age), as well as premature infants, it should be borne in mind that the half-life can reach four hours.
If violations of hepatic functionality are detected, a special adjustment of the Flemoxin Solutab tablets application program is not required, since the half-life of the active substance does not depend on the activity of this organ.
Drug dynamics
Instructions for use "Flemoxin Solutab" (250 mg and other dosage forms) indicates the bactericidal effect of the active component. The antibiotic is resistant to acidic environment, has an extensive spectrum of effectiveness. Belongs to the class of semi-synthetic, belongs to the penicillin series. It is distinguished by pronounced activity against gram-negative, gram-positive microscopic life forms.
Studies have shown (and this is recorded in the instructions for the use of Flemoxin Solutab 250 mg and other release options) that the drug shows a pronounced effect when infected with strepto, staphilo, enterococci, neisseria, clostridia, listeria, Helicobacter pylori. “Flemoxin Solutab” is somewhat less effective when infected with shigella, salmonella.
The drug does not show results when used against microorganisms that can produce beta-lactamases. This makes the tablets ineffective with the invasion of pseudomonads, protea, enterobacteria of certain types.
When will help
In the instructions for use "Flemoxin Solutab" 500 mg, 1 g and other forms of release, the manufacturer recommends using tablets for infection of the respiratory, urinary, reproductive, digestive systems. The drug is indicated for infectious lesions of soft tissues, skin.
The program of use, dosage, frequency is chosen by the doctor, based on the severity of the disease, age and weight, individual characteristics of the patient's body. "Flemoxin Solutab" is intended for use before or shortly after a meal. You can swallow the capsule as a whole, can be divided into parts, chewed, diluted in water. If the drug is swallowed undiluted, it is necessary to drink it with a glass of clean water without additives. When diluted in water, syrup is obtained. In the instructions for use for Flemoxin Solutab 500 mg (and other options), the manufacturer indicates that 20 ml of liquid is enough to dilute one tablet. The finished product has a pleasant aroma and taste.
Terms of use
Instructions for use "Flemoxin Solutab" (1000 mg and less concentrated release options) is recommended for use only after consulting a doctor. The doctor prescribes an individual regimen, taking into account how severe the disease is. In mild cases and moderate severity, patients older than nine years of age need to take 500-750 mg of the drug twice a day. An alternative is 375-500 mg three times a day. At one time, the drug is used in an amount of 375 mg. On the day "Flemoxin Solutab" according to the instructions for use, adults and children over 9 years of age are shown in an amount of not more than 1.5 g.
For the age of 3-9 years, twice a day you need to use 375 mg or three times - 250 mg. At one time, the minimum volume is 250 mg. For a day, no more than 750 mg is prescribed.
For patients older than one year of age, but younger than three years, the drug is shown in the amount of 250 mg twice a day or three times 125 mg. It is irrational to use less than 125 mg at one time - amoxicillin will not show effectiveness. Per day, it is not allowed to take more than 500 mg.
For young children, the daily dosage is calculated based on the proportion: 30-60 mg / kg / day. The resulting volumes must be divided into two or three servings. Do not use a substance at a time in an amount of 10 mg or less for every kilogram of weight. Do not use more than 60 mg / kg per day.
Severe illness
If the infection is difficult, if otitis media or other infectious diseases are established, the drug is recommended to be taken three times a day.
For adults, instructions for use "Flemoxin Solutab" 1000 mg is allowed per day up to three times. The maximum volume for 24 hours is 3 g. A single dosage varies between 750-1000 mg, the frequency of use is three times a day. In a smaller single quantity than 750 mg, Flemoxin Solutab will not show a pronounced effect.
The effectiveness of the drug in the treatment of severe infectious diseases is confirmed by numerous reviews of Flemoxin Solutab. Instructions for use 500 mg and other forms of release recommends using the drug to treat children only if it is possible to control their condition. The doctor calculates the daily dosage based on the weight of the baby: 60 mg per kilogram. The resulting volumes are divided into three portions. At least 20 mg / kg should be used at a time - in smaller quantities, the substance simply will not show a pronounced effect.
In the reviews of the medicine, many note that Flemoxin Solutab is really effective, but only if used according to the instructions and in accordance with medical recommendations. If the established rules are not followed, the substance may be ineffective, and there is also a risk of side effects.
Use programs
If gonorrhea, which proceeds in an acute form, is established, but there are no complications, it is necessary to use 3 g of the drug at a time, while additionally using 1 g of a medication containing probenecid.
In case of impaired renal function and creatinine clearance within 15-40 ml / min, the drug is used with twelve-hour intervals between doses. With less than 10 ml / min creatinine clearance, the dosage must be reduced by 15-50%. If anuria is detected, Flemoxin Solutab is indicated in an amount of not more than 2 g per day.
If the infection is moderate or mild in severity, Flemoxin Solutab is indicated for a course lasting from five to seven days. When infected with some forms of streptococcus, the duration of the therapeutic program is from ten days or more.
In severe diseases, the doctor chooses the dosage based on the clinical picture. The course is continued until there are symptoms, as well as two days after they completely disappear. If this condition is not observed, there is a risk of superinfection.
Is it worth the money
The effectiveness of treatment is ensured only by carefully observing the instructions for use. The price of Flemoxin Solutab 500 mg is 330 rubles for a package containing 20 capsules. A somewhat cheaper version of the release will contain 125 or 250 mg of active substance in one tablet.
The cost is indicated on the packaging, and the expiration date is in the instructions for use. The price of Flemoxin Solutab 125 mg is 200 rubles. In some pharmacies, the cost may be higher. The specific parameters are determined by the costs and additional costs of the point of sale. Preparations of any dosage have a similar chemical composition and the same therapeutic effect, as can be read in the instructions for use. The price of Flemoxin Solutab 250 mg in pharmacies starts at 270 rubles. The maximum option (1 g of amoxicillin in one tablet of the drug) will cost an average of 450 rubles per package, inside of which - 20 capsules and instructions for their use.
If you need to choose a more affordable option, you should first consult with your doctor, carefully study the instructions for use "Flemoxin Solutab." The price of analogues based on amoxicillin starts at 40 rubles, but not every drug is suitable for a particular patient. Only a doctor can tell which analogue to buy in each case.
Negative consequences
Relatively often, against the background of antimicrobial therapy, allergic skin reactions occur. As a rule, the response of the body is manifested by skin rashes in the form of papules, macules. In rare cases, patients note a change in the sensitivity of taste buds, a violation of the stool. Patients feel sick and vomit. There is a risk of erythema, colitis.
In some cases, "Flemoxin Solutab" provokes nephritis. Studies have shown that the use of amoxicillin can cause thrombocytopenia or, neutropenia, anemia, agranulocytosis. There is a risk of angioedema, shock, activation of liver transaminase (the level is estimated as moderate).
Contraindications
"Flemoxin Solutab" should not be taken if the patient has an increased sensitivity to amoxicillin or other antimicrobial agents from the beta-lactam group. You can not use the drug if lymphocytic leukemia, mononucleosis caused by infection of the body is established.
Mutual influence
The half-life of the active component of Flemoxin Solutab tablets increases if the drug is combined with agents that contain probenecid, acetylsalicylic acid, oxyphenbutazone, phenylbutazone. A fairly widespread practice is the combination of probenecid and amoxicillin, the concentration of which in plasma under the influence of probenecid becomes higher.
Antimicrobial compounds having bactericidal qualities show a synergistic effect if used simultaneously with the drug in question. This applies to cephalosporins, aminoglycosides, substances such as vancomycin and rifampicin. The combination with certain medications can cause antagonism. This is characteristic of some macrolides, tetracycline series, sulfonamides, chloramphenicol.
If you combine "Flemoxin Solutab" and drugs that contain estrogens, a decrease in the effectiveness of hormonal drugs is possible. This is more characteristic of birth control pills. Their combination with antibiotics can cause bleeding that does not fit into the framework of the menstrual cycle.
The risk of skin rashes is higher if Flemoxin Solutab is used simultaneously with preparations containing allopurinol.
The nuances of using
"Flemoxin Solutab" is allowed to be taken if in the past the patient suffered erythroderma.
With some penicillins, cephalosporins, cross-resistance is possible. The use of Flemoxin Solutab and a number of other penicillins can trigger the development of superinfection.
If the use of the medication is accompanied by loose stools in severe form, it is necessary to stop treatment. Indications for withdrawal are symptoms of colitis.
The combination of Flemoxin Solutab and drugs containing metronidazole eliminates the use of alcohol.
For children under one year of age, Flemoxin Solutab is not recommended. For children under nine years of age, tablets containing 0.5 g and 1 g of amoxicillin should not be used.
Additional Information
It is allowed to use Flemoxin Solutab tablets during pregnancy. Previously, the doctor must assess the possible dangers, the negative consequences of such therapy. Only on the basis of a comprehensive analysis make the final decision regarding the use of the drug.
It was revealed that small amounts of amoxicillin pass into breast milk, which means that they can affect the baby during breastfeeding. The manufacturer indicates that this may cause a sensitization reaction.
There was no negative effect on a person’s ability to drive vehicles or work with mechanisms that require a quick and accurate reaction.
If you drink too many Flemoxin Solutab tablets, the patient may feel sick and vomit. High probability of abundant loose stools. Possible imbalance of fluid, electrolytes in the circulatory system. When observing such symptoms, gastric lavage and the use of activated charcoal are indicated. It is possible to use laxatives with salt. .
Possible substitutes
« » :
- Amoxicillin.
- Amosin.
- Ospamox.
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