The medication "Thioctacid", the instruction indicates, is released in two forms: a solution intended for intravenous administration and tablets. The drug is included in the clinical and pharmacological group of drugs with antioxidant properties, regulates the metabolism of lipids and carbohydrates.
The active substance of the solution is thioctate trometamol, in one ampoule - 952.3 mg. In terms of thioctic - 600 mg. The active substance of the tablets is thioctic acid.
The pharmacological effect is ensured by the metabolic properties of the drug, the biochemical mechanism of action is similar to that provided by B vitamins. Thioctic acid performs the functions associated with protecting cells from the toxic effects of free radicals formed as a result of metabolism. The drug destroys toxic compounds of exogenous origin.
The medicine "Thioctacid 600" increases the concentration of the antioxidant glutathione, reducing the manifestations of polyneuropathy. Additionally, the drug is characterized by a hepatoprotective, hypocholesterolemic, hypolipidemic, hypoglycemic effect. It removes glucose and improves the functioning of neurons.
In the body of thioctate, trometamol breaks down by oxidation and conjugation into metabolic components, which up to 90% are excreted by the kidneys.
The drug "Thioctacid." Indication Instructions
The drug is prescribed in the following cases.
1. With diabetic polyneuropathy.
2. With polyneuropathy caused by alcoholism.
The drug "Thioctacid." Dosing Instructions
In case of severe polyneuropathy, the doctor prescribes intravenous administration once a day. Sets the daily dose of 600 mg, which corresponds to the first ampoule of the drug "Thioctacid 600". Treatment with the drug in solution lasts from 2 to 4 weeks, then the course is continued with tablets in the previous dose of 600 mg.
Before administration, the solution of trometamol thioctate is diluted 30 minutes in a special solution of sodium chloride with a concentration of 0.9%. For the preparation of a medicinal product for infusion, 100-200 mg of sodium chloride is used. It is important when preparing the solution to protect the vessel with the drug from light. For this purpose, the bottle is wrapped in aluminum foil, while the medicine is considered suitable for use for 6 hours.
The procedure is carried out slowly, no more than 2 ml is injected into a vein in 1 minute. If it is perfused, then the time of administration of the drug should be more than 12 minutes.
Ampoules with trometamol thioctate are very sensitive to light.
The drug "Thioctacid." Instruction Side effects
During clinical trials, allergic reactions were observed less frequently than in 1 patient per 10,000, they were manifested by skin rash, urticaria, itching, eczema, redness of the skin, anaphylactic shock.
Convulsions and diplopia, disturbances in the functioning of the nervous system had to be observed less frequently than in 1 patient per 10,000.
Malfunctions in the functioning of the hematopoietic system were observed less often than in 1 patient per 10,000, manifested by purpura, pinpoint hemorrhage, tendency to bleeding, thrombocytopathy, thrombophlebitis.
Violations of the digestive system, the drug "Thioctacid 600 t" rarely caused: less than 1 patient per 100 manifested by a change in taste; less than 1 in 1,000 patients showed nausea and vomiting.
Rapid administration of the drug can cause increased pressure, difficulty breathing. The general condition of the patient’s body after administration of thioctic acid worsened in 1 patient per 10,000.
When prescribing the medication “Thioctacid 600 t,” the doctor should take into account contraindications for its use: pregnancy, lactation, childhood, hypersensitivity.
The medicine "Thioctacid." Instruction special instructions
The effectiveness of the drug is significantly reduced while taking alcohol. Abstinence from drinking alcohol is a prerequisite for a course of therapy. In the treatment of diabetic polyneuropathy, you need to monitor the optimal concentration of sugar in the blood.