In the article we consider the analogues of "Proginov". This is a hormonal drug containing estrogens, which are identical to the natural ones and are produced by the ovaries. The drug compensates for the deficiency of estrogens in case of insufficient production, for example, in the presence of menopause or after surgical castration. This medication eliminates the manifestation of menopausal syndrome, which is caused precisely by a deficiency of estrogen, as it makes up for the lack of this hormone.
Format of release and composition of the drug "Proginova"
The dosage form of the drug is a dragee. One pill contains an active ingredient called estradiol valerate in an amount of 2 milligrams.
As the instructions for use for Progin indicate, the auxiliary ingredients are montanglycolic wax along with lactose monohydrate, talc, corn starch, povidone, magnesium stearate, macrogol, crystalline sucrose, povidone, precipitated calcium carbonate, glycerol, indigo carmine, titanium dioxide and. d.
When is the drug prescribed?
What are the indications for using Proginova? The medication is used for:
- relief of symptoms of castration syndrome (autonomic, neuroendocrine and neuropsychiatric disorders);
- prevent the development of osteoporosis;
- elimination of depression provoked by menopausal syndrome;
- establishing thermoregulation;
- normalization of sleep;
- getting rid of atrophy of the mucous organs of the genitourinary tract;
- calming the heartbeat and getting rid of migraines that occur during menopause.
Instruction for use
The drug in question should be taken orally, washed down with liquid. In the event that the patient’s uterus is not removed and menstruation is still ongoing, therapy is started in combination with gestagen in the first five days of the cycle. With rare menstruation, as well as in periods of postmenopause, you can start using the medication at any time after the exclusion of the fact of pregnancy. The recommended dosage regimen is one pill per day.
In the case of cyclic hormone therapy, after 21 days (at the end of packaging), a break is made (usually for a week or less). Against the background of continuous replacement therapy, the drug is taken daily without interruption. As part of a combined cyclic HRT, gestagen is recommended to be taken every four weeks for 14 days.
According to the instructions for use, Proginova should be taken at the same time, however, this does not affect the effectiveness of the drug in question. If you miss a single dose, dragees must be taken in the next 24 hours. In the event that treatment was interrupted for a longer period, then bleeding may develop.
List of analogues
The drug in question has analogues in the pharmaceutical market; estradiol valerate is also included as an active ingredient in their composition. The analogs of Proginova include the following drugs:
- Tablets "Dermestril."
- Transmedical means "Divigel".
- Transdermal medical system "Klimara".
- Menorest tablets.
- Means "Octodiol".
- Solution for injection "Estradiol dipropionate".
- Gel transdermal "Ostrozhel".
- Tablets "Estrofem".
A doctor should select a replacement. Proginova also has analogues containing other active components, but with a similar therapeutic effect. To the analogues of this medication, all medications for hormone replacement therapy can be attributed, since they have similar effects. But the closest in properties to analogues will be those that contain some estrogen hormones. Somewhat further in their properties are substitutes, which include a combination of estrogen and progesterone.
Analogs containing estrogen
These drugs include the following drugs:
- Means "Ovestin" in the form of tablets, cream and vaginal suppositories.
- The drug "Sinestrol" in the form of tablets and solution for injection.
- Vaginal cream "Elvagin".
- Tablets "Ethinyl estradiol".
Analogs containing a combination of estrogen and progesterone
These include the following drugs:
- Tablets "Active" and "Angelik".
- Injection solution called "Ginodian Depot."
- Pills "Divitren", "Indivina", "Klimen", "Klimodien", "Kliogest".
- As well as funds, which are also available in the form of pills, for example, Pausogest along with Triaclim, Trisequens, Eviana, Revmelide and Cyclo-Proginova.
Divigel
The composition of this analogue "Proginova" includes endogenous estradiol, which has a similar structure with the same component of the human body. The drug compensates for the lack of estrogen in women after performing an ovariectomy, as well as against the background of menopause. Estrogens prevent bone loss that occurs during artificial and natural menopause.
People often ask which is better - “Divigel” or “Proginova”?
The transdermal use of estradiol in combination with medroxyprogesterone acetate lowers cholesterol but does not affect high density lipoproteins. The gel is used in the treatment of women with symptoms that indicate estrogen deficiency due to artificial or natural menopause.
"Divigel" can be used in the treatment of women with estrogen deficiency of various origins. The drug can also be used to prevent the occurrence of osteoporosis in postmenopausal women. Such a gel is not prescribed for patients who are intolerant of estradiol hemihydrate, breast cancer and other malignant hormone-dependent neoplasms or in case of suspicion of such ailments.
"Divigel" is strictly contraindicated in patients who have a tendency to vaginal bleeding of unknown origin, as well as those who have endometrial hyperplasia, thromboembolic vein diseases, pulmonary embolism, porphyria and acute liver pathologies.
The gel is used only in a transdermal manner. The drug is intended for long-term continuous or cyclical treatment. The gel is recommended to be applied to the lower region of the buttock or front wall of the abdomen. The area of the skin for applying the medicine from one sachet cannot exceed the dimensions that are equal to the surface of one palm. After applying the product, wash your hands and wait two minutes until it is completely absorbed. The drug is forbidden to apply on the skin of the genitals, chest, face. Avoid contact with eyes.
Femoston
Many people wonder what is better - “Femoston” or “Proginova”?
The use of the medication is advisable in hormone replacement treatment for a disorder caused by estrogen deficiency during perimenopause or postmenopause. It is also used to prevent osteoporosis in women who are at high risk of fractures due to intolerance or contraindications to the use of other medications.
"Femoston 1/5" is taken orally every day in a continuous mode, one tablet per day (it is advisable to do this at the same time), regardless of the meal. Patients who make the transition from another sequential continuous or cyclic mode should end the current cycle, and then begin to use “Femoston 1/5”.
The analogue of the Proginova drug, Femoston 1/10, is taken orally every day in a continuous mode, one pill per day (it is advisable to take the drug at the same time), regardless of the meal. Each package, as a rule, is designed for a 28-day intake of the drug. In the first two weeks, one white tablet is taken daily, and in the remaining 14 days, one gray pill is taken. Treatment should continue without interruption, immediately after the completion of the 28-day cycle, the next treatment period is required to begin.
Estrogel
A cheap analogue of Proginova, Estrogen is an estrogenic product for external use. The composition of this gel, according to the instructions, includes the female sex hormone estrogen. They reduce the unpleasant symptoms that accompany menopause, we are talking about heart attacks, hot flashes, increased sweating, nervousness, and so on. Estrogen slows the loss of bone calcium in the menopause. According to reviews, the drug can have an effect on the body, which is comparable to taking estrogen.
Estrogel or Proginova - which is better? This is not easy to solve.
The drug is used to eliminate the symptoms of menopause among women, including against the background of artificially induced menopause in order to prevent and treat osteoporosis during menopause. “Estrogen” is not used in case of development of estrogen-dependent cancer of the breast, ovary and uterus.
The gel is intended for application to the skin, the mode of application can be cyclic or continuous. At the same time, it is recommended to use gestagenic drugs. Before starting therapy, an examination by a gynecologist is recommended, it should be visited at least once a year. On the skin of the lower back, shoulders, abdomen or forearms, the medicine is applied once a day (evening or morning), 2.5 grams (or two doses of the applicator) until it is completely absorbed for two to three minutes.
In the event that “Ostrozhel” is not absorbed within five minutes, this means that it is necessary to increase the application area. As a rule, it corresponds to the surface of one or two palms. Apply the medicine on dry, clean skin. It is necessary to avoid getting the drug on the mucous membranes of the vagina and vulva. During therapy with the drug, regular monitoring of pressure with liver function is required.
How to take Proginova to build up the endometrium?
The “Proginova” medicine in the endometrium provides active formation of progesterone receptors. And this leads to the fact that the endometrium grows quickly and well after ovulation as part of the onset of the second stage of the cycle, characterized by the predominant influence of progesterones. That is, the drug prepares the endometrium for a reaction to progesterone. Such a finished endometrium grows very well, forming an excellent environment for the attachment of an egg.
The described effect of Proginov increases the chance of conception in almost any woman. The good effect of the drug is especially noticeable in patients who had difficulty conceiving due to too thin endometrium or deficiency of estrogen in the body, which does not allow the egg to get out of the follicle. The described medicine eliminates such problems. As a rule, "Proginova" in preparation for pregnancy, women are prescribed according to the following schemes:
- As part of cyclic hormone replacement therapy, take one tablet per day until the packaging is complete. Next, take a break for a week, after which they take pills from the subsequent packaging and so on. Doctors usually recommend taking the drug for three or more cycles.
- They take Proginova one pill from the 10th to the 14th day of each cycle, and from the 16th to the 26th they additionally use Dufaston or Utrozhestan.
- They use Proginova one tablet three times from the 10th to the 14th day of each cycle. From the 16th to the 26th day, it is also recommended to use Utrozhestan or Dufaston.
Next, you should find out what women write about the medication “Proginova” and its analogues on the Internet.
Reviews
Almost all reviews on the Internet about "Proginova" were left by women who took this drug in order to improve endometrial growth as part of pregnancy planning. Most of the comments (more than 80%) about this drug are positive, because after the course of therapy, according to women, the result is really achieved: the endometrium begins to grow and acquires normal sizes, at which pregnancy is possible.
In the reviews, it was noted that this drug is very well tolerated, almost does not cause adverse reactions and does not affect the weight. The same is reported about its analogues - Divigel and Femoston. Negative reviews were left by women to whom the medicine did not fit, as it provoked intolerable side effects.
There are very few comments on the use of the Proginova medication in the presence of menopause or castration syndrome on the Web. However, almost all of them are positive, since the drug helps women quickly get rid of unpleasant symptoms and begin to lead a familiar life. In the reviews of Proginov and its analogues, almost all consumers indicate that at first it is scary to take such hormonal drugs, but after a time when it becomes clear that the medicines normalize the condition and do not cause any terrible consequences, such fear disappears.
We reviewed the list of Proginova analogues and instructions for use.