The drug "Berlipril" (tablets) are prescribed for arterial hypertension, heart failure. The active substance is enalapril maleate.
The medicine causes a decrease in blood pressure without a compensatory increase in heart rate. When taking the drug, a decrease in peripheral vascular resistance is noted. The medicine helps to increase the tolerance of physical exertion, reduce hypertrophy in the left ventricle, and improve intracranial blood flow in the kidneys.
The duration of the effect depends on the amount of drug taken. When used in recommended dosages, the hemodynamic and antihypertensive effect persists for twenty-four hours.
Withdrawal of the drug "Berlipril" is mainly carried out with urine.
Eating does not affect the absorption of the active component. The dosage of Berlipril medicine is recommended for use individually for each patient.
With arterial hypertension, the initial amount of the drug is from five to twenty milligrams per day. In the mild degree of pathology, 5 to 10 mg are prescribed. In patients with renal hypertension, decompensation of cardiac activity, electrolyte imbalance during therapy, a significant decrease in pressure is likely. In this case, systematic monitoring of the patient’s condition and prescribing a dosage of less than 5 mg are necessary.
If the patient took high doses of diuretics before prescribing Berlipril, hypovolemia may occur at the beginning of treatment. Subsequently, arterial hypotension develops . In this case, the drug "Berlipril" instructions for use recommends to appoint at the lowest dosages (less than five milligrams) and stop taking diuretics two to three days before the start of therapy. In the course of treatment, it is necessary to systematically monitor the activity of the kidneys and the indicator of potassium in the plasma.
As a maintenance therapy, the Berlipril medicine recommends that you prescribe 20 mg daily. The maximum dose per day is forty milligrams.
In the treatment of patients with asymptomatic dysfunction in the left ventricle and heart failure, Berlipril recommends that the drug be prescribed in addition to beta-blockers, digitalis drugs, or diuretics. The initial dose in these cases is 2.5 milligrams.
Treatment should be started only under the supervision of a specialist. If symptomatic hypotension is not noted or its manifestations are short-lived, a gradual increase in the dose to twenty milligrams is allowed. The patient can take this amount in one or two doses per day.
Before and during the first days of therapy, it is necessary to monitor the activity of the kidneys and blood pressure indicators.
The medicine "Berlipril" does not allow the instructions for use if angioedema is present in the history of the disease . The drug is not recommended for hypersensitivity to it, as well as during lactation and pregnancy.
Among the most common adverse events, dizziness, hypotension ( including orthostatic ), heart attack, cardiac arrhythmias, tachycardia, and chest pain should be highlighted. Taking the medicine can provoke a dry cough, shortness of breath, abdominal pain, diarrhea, angioedema, skin rashes, asthenia, fatigue, hyperkalemia, increased creatinine levels, taste changes, and appetite disorder.
If these and other negative reactions appear, consult a doctor.
Before using Berlipril, it is recommended that you read the instructions.