Why are Texamen injections prescribed? Instructions for use and indications of this tool will be presented below. We will also tell you about whether there are contraindications, analogues and side effects of this drug, what is included in its composition, etc.
The packaging of the drug and its composition
What is the composition of Texamen injections? Instructions for use states that the active substance of this medication is tenoxicam. In addition, the drug also contains such additional components as magnesium edetate, trometamol, sodium hydroxide, sodium metabisulfide and mannitol.
The medicine “Texamen” (injections) goes on sale in bottles in the form of a lyophilisate with a solvent, placed in a pack of cardboard.
Pharmacological action
What is the medicine "Texamen" (injections)? The instructions attached to the drug say that it is an analgesic. Its active substance belongs to oksikam. It has antipyretic, anti-inflammatory and analgesic effects.
The main principle of the action of this medication is inhibition of the rate of synthesis of prostaglandins, as well as a slowdown in the metabolism of arachidonic acid and inhibition of cyclooxygenase.
The agent in question reduces the rate of phagocytosis and the release of histamine, which eliminates any inflammatory process in a short period of time. It should also be noted that the drug slows down the withdrawal of macroenergetic compounds, reduces the effect of bradykinin on receptors, reduces the permeability of capillaries and stabilizes lysosomal membranes.
Pharmacokinetic properties of the drug
How long is Texamen (injections) absorbed? The instruction states that the active substance of this agent is fully absorbed immediately after administration of the drug substance.
The bioavailability of the drug is 100%. Almost 99% of the active substance binds to plasma proteins. The metabolism of the drug is carried out through the hepatic system.
The drug leaves the human body along with urine and bile. It should also be said that tenoxicam passes well through the blood- placental (during pregnancy) and blood-brain barriers.
The drug "Texamen": indications for use
Texamen injections are prescribed to patients suffering from degenerative diseases of muscle and bone tissue, which are of inflammatory origin and are accompanied by pain:
- gout;
- rheumatoid arthritis;
- ankylosing spondylitis;
- osteoarthrosis;
- osteochondrosis.
In what other cases texamen injections are used? The instruction for use states that such a tool is very often used for the rapid relief of severe pain syndromes that occur with such deviations as:
- tendonitis;
- traumatic injuries;
- myositis;
- periatritis;
- lumbago;
- lesions of the ligamentous apparatus;
- polyarthritis;
- neuralgia.
Contraindications
When can you not use the drug "Texamen"? The instruction (injections and tablets have the same contraindications), attached to the medication, contains the following prohibitions on the use:
- lactose intolerance;
- heart failure;
- individual hypersensitivity to the active substance;
- coagulation disorders;
- impaired auditory perception;
- history of aspirin triad ;
- hypertonic disease;
- digestive system pathology (peptic ulcer and gastritis);
- diabetes;
- diseases of the liver system;
- pathology of the vestibular apparatus.
It should also be noted that the medication in question is not used in pediatric practice.
Texamen injections: instructions for use
With a slight pain syndrome, the drug in question is prescribed only in tablet form. If this method is impossible or there are problems with the digestive tract, as well as with severe pain, injections are recommended.
According to the instructions, the drug is administered intramuscularly in 1 vial (or 20 mg) every day. In this form, the medication should be used no longer than 5 days.
How to breed Texamen (injections)? Solvent should be added to the powder vial. After this, the drug must be shaken vigorously (until the medicinal substances are combined).
The use of injections in which small particles of powder remain is prohibited. It is also not recommended to use a medication that at the time of mixing has changed its color or is cloudy.
The drug should be administered deep into the muscle. In this case, the medicine will act more efficiently.
Overdose symptoms
The introduction of increased doses of the drug can cause the patient to vomit, epigastric pain, stool disorders, drowsiness or agitation. In severe cases, people develop cramps, gastrointestinal bleeding (when taking pills), and disorientation.
Adverse reactions
The drug "Texamen" in injections is relatively well tolerated by patients. However, very rarely, systemic reactions can occur in patients. As for the tablets, they quite often cause adverse effects.
- Digestive system: vomiting, heartburn, increased ALT and AST, flatulence, erosive lesions, gastropathy, stomatitis, epigastric pain, anorexia, stool disorders.
- Cardiovascular system and blood system: tachycardia, thrombocytopenia, agranulocytosis, increased blood pressure.
- Nervous system: increased drowsiness, changes in visual and auditory perception, depression, tinnitus, migraine, eye mucous irritation, excessive irritability, dizziness.
It should also be noted that very rarely when using the drug "Texamen" bronchospasm, allergic responses, Quincke's edema, itching of the skin, increased urea nitrogen and hyperhidrosis are recorded.
Drug interaction
Before using the product in question, it is imperative to read the attached instructions. According to her, corticosteroids, salicylates and NSAIDs increase the likelihood of ulceration of the walls of the stomach.
This drug potentiates the effects of indirect anticoagulants and sulfonylureas. In this case, probenecid increases the excretion of the active substance of the drug (tenoxicam).
It should also be noted that the presented drug lowers the concentration of glycosides in the blood.
Quinolone antibiotics increase convulsive activity, and the effectiveness of Mifepristone decreases while taking tenoxicam.
Potentially nephrotoxic drugs, diuretics, serotonin receptor antagonists and antiplatelet agents are categorically contraindicated in the joint use of the drug "Texamen".
Pregnancy and lactation
Teratogenic effects of the drug in experiments on animals were not detected. There is also no information about the negative effect of the active ingredient on the fetus. However, it must be remembered that tenoxicam penetrates well into breast milk. In this regard, this drug is contraindicated during breastfeeding.
The drug "Texamen" (injections): analogues and price
The following drugs are structural substitutes for this medication: Tenikam, Tenoktil and Tobitil. As for the analogues (according to the pharmacological effect), among them we can especially distinguish such drugs as Meloxicam and Movalis.
The price of Texamen injections is quite high. One bottle of a drug costs about 140-170 rubles. Given that treatment must be carried out for 5 days, the patient needs to give about 600-900 rubles.
Drug Reviews
Unlike Texamen tablets, injections are relatively well tolerated by patients. Many people note that such a drug almost never causes local reactions, but only if all the rules of asepsis are observed.
As for the reviews of experts, they are also positive. Doctors say that Texamen injections quickly cope with the task. They quickly stop any pain syndromes, including pronounced ones. In connection with this fact, most specialists prescribe this drug to their patients, especially if therapy of inflammatory diseases of the muscle and bone system is required.