Pradax capsules is an anticoagulant, a direct inhibitor of thrombin. Suction means quickly. The maximum content of the drug reaches within 30-120 minutes. Food does not affect the bioavailability of the drug. The medicine is excreted in unchanged form, mainly through the kidneys.
Indications
Means of "Pradax" application instruction recommends for the prevention of thromboembolism in patients after orthopedic interventions.
Dosage regimen
The medication is indicated for oral administration. The dosage for preventive purposes is 220 mg / day. The drug is taken once. With moderate renal impairment, there is a high risk of bleeding. In this regard, it is recommended to reduce the dosage to 150 mg / day. After endoprosthetics of the knee joint to prevent venous thromboembolism, the use of the drug "Pradax" application instruction recommends starting one to four hours after the end of the intervention. The initial dosage is 110 mg with a gradual increase to 220 mg / day. Duration of administration is 28-35 days. If hemostasis is not achieved, therapy should be postponed. For elderly patients (from 75 years) it is recommended to prescribe 150 mg / day.
The drug "Pradax". Instructions for use. Side effects
Due to therapy, bleeding of various localization is likely. A medication can provoke thrombocytopenia, hematuria, hemarthrosis, anemia, hemorrhagic syndrome. In some patients, there is a disorder of the liver function, an increase in the activity of its enzymes. The negative consequences include a decrease in hemoglobin, hematomas after the procedures, the appearance of bloody discharge from wounds.
Means of "Pradax". Instructions for use. Contraindications
The medication is not recommended for severe renal failure, hemorrhagic disorders (including diathesis). The medicine "Pradaxa" (reviews of experts confirm this) is not prescribed for active clinically significant bleeding and lesions in the organs as a result of this, hypersensitivity, liver pathologies that can affect survival. Not recommended drug under the age of eighteen years, hemostatic disorders (spontaneous or pharmacologically induced). Contraindications include pregnancy and lactation.
additional information
When taking high dosages of the drug, bleeding develops. If it occurs, treatment should be suspended until the nature of the phenomenon is clarified. Given the method of excretion of the drug (via the kidneys), in case of poisoning, it is necessary to ensure diuresis. In some cases, plasma transfusion (freshly frozen) or surgical hemostasis may be required. When prescribing NSAIDs together with the medication, the risk of bleeding does not decrease. If symptoms of acute renal failure occur, therapy is discontinued. The first dose of the drug is taken no earlier than two hours after the catheter is removed. The drug is stored away from children. The tool is available by prescription.