Ditsinon tablets are a hemostatic drug used to stop various kinds of bleeding, with hemorrhages and diseases of the retina, too strong menstruation. The drug is available in the form of tablets and a solution for drip infusions and intramuscular injections, produced in Slovenia.
Let's take a closer look at Dicinon tablets. From what they are interesting to many.
Release form and composition
The medicine is produced in two forms: a solution for injection and tablets. The latter are painted almost white or white, their dosage is 0.05 or 0.25 grams, are in cell packaging. A cardboard pack includes one hundred Dicinon tablets of 250 mg or 50 mg (child dosage) of the main active ingredient of ethamylate, as well as excipients, including magnesium stearate, lactose, anhydrous citric acid, povidone K25, and corn starch.
pharmachologic effect
Dicinon tablets are hemostatic. The hemostatic effect is based on accelerating the initial stage of hemostasis - there is a stimulation of the interaction between platelets and endothelium. Dicinon increases platelet adhesion to impaired vascular walls, especially to capillaries, protects the endothelium, reduces the permeability of capillary walls, inhibits prostaglandin biosynthesis, which causes vasodilation and disaggregation, and therefore increases capillary permeability. Due to the influence of the drug, bleeding is greatly reduced, blood loss is reduced.
The drug has no vasoconstrictor symptoms. It does not affect either the normal blood coagulation procedure or fibrinolysis, so it does not have a thrombogenic effect. The medicine inhibits the effects of both histamine and hyaluronidase, thereby reducing high capillary permeability in various diseases, for example, in inflammatory processes. Dicinon significantly reduces the frequency of bleeding inside the ventricles of the brain in babies with low birth weight. Brain hemorrhages in infants whose mothers took the drug were lower compared to those children whose mothers did not receive the drug.
How fast do Dicinon tablets work with bleeding?
Pharmacokinetics
During oral administration, the active substance is absorbed at a high rate from the gastrointestinal tract. When 50 milligrams of ethamzilate is taken orally, then its maximum degree in plasma is reached after four hours. The half-life of it from plasma is 3.7 hours. Approximately 72% of the dose used during the day is excreted in the urine.
The active substance is able to pass through breast milk and the placental barrier.
So, Ditsinon tablets - what are they from?
Indications for use
"Dicinon" in tablets is prescribed in the following cases:
- To prevent and stop bleeding.
- With parenchymal capillary bleeding (traumatic, postoperative, intestinal, pulmonary, renal, after dental procedures).
- With bleeding of a secondary nature against hypocoagulation, hematuria, thromphocytopenia, thrombocytopathy with hemorrhages inside the skull, drug bleeding, hemorrhagic vasculitis, hemorrhagic diathesis.
- With relapse of retinal hemorrhage, Werlhof disease, diabetic retinopathy.
- Dicinon tablets for menstruation are very often prescribed.
Contraindications
Among the contraindications are:
- excessive sensitivity to the active active component of the drug - etamzilate, or any auxiliary substance;
- a history of high sensitivity to sodium sulfite;
- pediatric hemoblastosis (osteosarcoma, myeloid and lymphatic leukemia);
- acute porphyria;
- thromboembolism and thrombosis;
- breast-feeding.
Pregnancy and breastfeeding
The effects of etamzilate on women during pregnancy. Ethamsylate crosses the placental barrier, so its use is contraindicated in patients in the first trimester. Clinical use during pregnancy is not significant for these indications.
The active substance passes into breast milk. While taking the drug, you should stop breast-feeding the baby.
Consider the instructions for use with Dicinon tablets for bleeding.
Dosage and specific dosage
Use in children after 14 years and in adults:
- Before surgery: 1-2 tablets of the drug from 250 to 500 milligrams within an hour before the surgical procedure.
- After surgery: every 4-6 hours until there is a chance of bleeding - 1-2 tablets of the drug in a dosage of 250. Instructions for use with Dicinon tablets indicate that a dosage of 500 mg can also be used.
- Internal diseases: general recommendations to take two tablets three times a day during meals with a small amount of water.
- With metro and menorrhagia, in gynecology: drink 2 tablets of the drug three times a day during meals with a small amount of water; therapy lasts ten days five days before the alleged bleeding.
For the treatment of children over six years of age:
- The dose during the day is 10-15 milligrams per kilogram of weight, divided into three to four doses. The duration of use of the drug is determined by the volume of blood loss and ranges from three days to two weeks from the time of stopping bleeding in any patients.
- Pills should be taken during or after meals. Special categories of patients.
There are no studies on the treatment of patients with impaired renal or hepatic function. Thus, "Ditsinon" should be used with caution in the treatment of these groups of patients.
If the dose has been missed, you can not take a double to compensate for the missed dose.
Side effects
The following undesirable effects from Dicinon tablets may occur: dizziness, headache, transient skin disorders, hyperemia, pain in the epigastric region, nausea, paresthesia of the lower extremities. These reactions are transient and not dangerous. There is evidence that in children with acute myelogenous and lymphoid leukemia, osteosarcoma, the active substance that acts to prevent blood loss, became the cause of severe leukopenia. According to a number of sources, the use of the drug for the treatment of children is not recommended.
There is evidence that women who took Dicinon before the intervention of a surgeon noted thrombosis on the cervix after surgery. But tests conducted recently, these data did not confirm.
Application specifics
Dicinon tablets for uterine bleeding should be prescribed with caution if patients have a history of thromboembolism or thrombosis, excessive sensitivity to drugs. Dicinone contains sulfites, which is why you need to be careful when administering it to patients with allergies or bronchial asthma. Before starting therapy, it should be borne in mind that the medicine is ineffective in treating people with thrombocytopenia.
Due to the fact that small patients who were prescribed “Dicinon” to prevent blood loss in myeloblastic and lymphoblastic leukemia, osteosarcoma, deterioration was observed, some experts believe that the drug is contraindicated in such situations.
Medication should not be prescribed to patients with rare genetic diseases, for example, malactivation of galactose-glucose or lactase deficiency.
The active substance does not affect the person’s ability to drive vehicles or activities with complex mechanisms.
If there is intolerance to carbohydrates, then consult a specialist before taking the medicine.
Analogs
Dicinon has several analogues.
- "Tranexam" - this drug is a hemostatic agent. It is used for various bleeding, including postoperative bleeding, during pregnancy, cancer and liver pathologies. This analogue is distinguished by anti-inflammatory and anti-allergenic effects. It has contraindications and some side effects. Its active substance is tranexamic acid.
- "Etamsylate" is a drug used for the treatment and prevention of capillary bleeding in the gynecological and dental field, after surgical interventions of any complexity, with pulmonary and intestinal bleeding. This analogue has its contraindications, after its use, the appearance of side symptoms is possible.
- "Vikasol" is a water-soluble synthetic analogue of vitamin K. The drug is used in surgical and gynecological practice for the treatment and prevention of various bleeding. This analogue is allowed for use in pediatrics and during pregnancy. Its use can cause side symptoms, which are especially pronounced against the background of an overdose. There are contraindications. The drug is not effective in Verlhof disease and hemophilia.
The price of Dicinon tablets will be presented below.
special instructions
If the drug is prescribed to patients with a history of thrombosis and thromboembolism, then you need to be careful. With an overdose, hemorrhagic complications arise, during the treatment of which specific antidotes are required. During pregnancy, "Dicinon" is also prescribed with caution.
The drug is also used in veterinary medicine, for example, for the treatment of cats.
Reviews about the tablets "Ditsinon"
The medicine "Ditsinon" is widely used for the treatment and prevention of bleeding with many extensive surgical procedures and minimally invasive interventions. There are many positive reviews from urologists, ophthalmologists, dentists and their patients.
"Ditsinon" is used in the gynecological field for too heavy menstruation, which cause anemia, and for complications after the introduction of the intrauterine device. It can be used to treat pregnant women.
The drug has various forms, so it can be used for emergency stopping the blood flow in emergency or emergency conditions, and for treatment with taking pills.
"Ditsinon" is well tolerated by patients, does not cause negative consequences of consumption. It has a small number of contraindications. Given the duration of the course, the cost of the drug is adequate.
The price of Dicinon tablets
The cost of the drug in tablets is about 400 rubles. It depends on the region and the pharmacy network.
conclusions
The drug "Ditsinon" is a hemostatic drug. It shows signs of angioprotector.
Used to reduce bleeding with defects in coagulation diseases and platelet function.
It is used to reduce blood loss during surgeon interventions. It stimulates the formation of platelets, increases their aggregation and adhesion. It is a component of the treatment of various kinds of hemorrhagic syndromes. It should be used with caution in patients with a history of thromboembolism and thrombosis. Purely prescribed by a specialist is assigned to pregnant women.