Currently, there are a lot of drugs used to treat diabetes.
Siofor 850 - instruction
The drug "Siofor 850" (Siofor) - is an oblong tablet, coated with a white shell, which have a double-sided notch for division. The manufacturer is Berlin-Chemie AG. Available in a cardboard box of 60 tablets.
Composition: 1 tablet of this drug contains 850 mg of metformin hydrochloride and additional substances: hypromellose; povidone; macrogol 6000; titanium; magnesium stearate.
Pharmacological actions.
Siofor 850 is a hypoglycemic drug. The mechanism of action is due to its ability to reduce gluconeogenesis and the formation of fatty acids. It does not affect the amount of insulin in the blood, but as a result of the action changes its pharmacodynamics. In the mechanism of action of metformin, stimulation of glucose uptake by muscles is important. It enhances blood flow in the liver and the conversion of glucose to glycogen, improves fibrinolytic properties of the blood.
Indications for use:
- non-insulin-dependent diabetes mellitus, especially when combined with obesity.
Contraindications:
- with a complete cessation of insulin secretion in the body with non-insulin-dependent diabetes mellitus;
- insulin-dependent diabetes mellitus;
- diabetic ketoacidosis, precoma or coma;
- impaired renal or liver function;
- myocardial infarction;
- diseases of the respiratory system;
- severe cases of an infectious disease;
- heart failure;
- operations, injuries;
- hypoxic conditions;
- lactation (breastfeeding);
- pregnancy;
- chronic alcoholism;
- childhood;
- An allergic reaction to the components of the drug.
Doses and methods of use.
The dosage of Siofor 850 and the duration of use are determined by the doctor individually for each patient, depending on the level of glucose in the blood. The maximum dose is 3 g.
It should be taken without chewing during meals and washed down with any liquid. In case the prescribed daily dose is more than 1 tab., Then it must be divided into 3 doses.
Manifestations of side effects: allergic reactions to the skin, diarrhea, abdominal pain, mouth taste of metal, anorexia, nausea, vomiting, the development of megaloblastic anemia.
special instructions
Patients over 65 years of age should be given caution with Siofor 850. Before prescribing the drug, it is necessary to monitor the function and kidney of the liver. 2 days before radiological examinations with the introduction of contrast agents or surgery, it is necessary to replace "Siofor" with another hypoglycemic drug.
During the use of the drug, due to the high risk of hypoglycemia, it is not recommended to engage in activities that require quick psychomotor reactions and attention.
Symptoms of an overdose: diarrhea, severe weakness, nausea, vomiting, pain in the muscles, in the abdomen, rapid breathing and loss of consciousness; there is the possibility of developing hypoglycemia, which is accompanied by tachycardia, pallor of the skin, a feeling of hunger, trembling, increased sweating.
Drug interaction
The hypoglycemic effect of the drug is enhanced when taken with other hypoglycemic drugs, salicylates, ACE inhibitors, oxytetracycline. It is possible to reduce the hypoglycemic effect when taking thyroid hormones, contraceptives, glucocorticoids, oral nicotinic acid derivatives, diuretics and sympathomimetics at the same time,
When taking siofor, along with indirect anticoagulants, it is necessary to monitor blood coagulation.
Storage conditions: Store in a place protected from light at room temperature.
About Siofor 850, the reviews of doctors and patients are mostly positive.