In Parkinson's disease, doctors often prescribe the drug "Pronoran". Instructions for use informs that this drug acts on receptors of nerve cells. This helps to improve the condition of patients and reduce akinetic manifestations. The medicine is safer than other drugs. Compared to such a widespread anti-Parkinsonian drug as Levodopa, Pronoran is much less likely to cause involuntary movements. The drug can be used as part of complex therapy of kinetic disorders.
The composition of the drug
The active component of the medication is pyribedil. The drug is produced in the form of tablets (with a shell) with a drug content of 50 mg. Also, the composition of the drug includes auxiliary ingredients: talc, magnesium compounds and povidone. The shell consists of polysorbate, carmellose, sucrose, wax, titanium and silicon compounds, a dye. The tablets are round in shape, red.
How do tablets work?
To understand the effect of tablets, you need to understand the mechanism of the occurrence of Parkinson's disease. With this pathology, the cells of the nervous system that produce dopamine are destroyed in humans. This leads to such manifestations as trembling of the extremities, motor inhibition.
Pyribedil stimulates dopamine receptors. As a result, the manifestations of Parkinson's disease are reduced. Unlike the main active drug "Levodopa", which is actually an analogue of dopamine, pyribedil acts somewhat softer, but at the same time it is no less effective. In addition, the active component of Pronoran tablets improves memory and increases concentration, which contributes to human mental activity.
Pyribedil is completely absorbed into the blood from the gastrointestinal tract and reaches the maximum concentration in 3-6 hours after administration. It interacts little with other drugs, as it binds to blood proteins only by 20-30%. Therefore, the use of Pronoran as part of complex therapy is quite possible.
Indications
The main indication for the use of the drug is Parkinson's disease. It is especially useful in forms of the disease, accompanied by severe trembling of the limbs. The drug is prescribed both at the beginning of pathological manifestations, and at later stages. This remedy can be used for monotherapy or together with Levodopa.
In addition, the instructions for use of the medicine "Pronoran" also list other indications for prescribing tablets:
- Diseases of the vessels of the legs. With pathology of the arteries of the lower extremities, pain and numbness in one of the legs is often felt (intermittent claudication). Pronoran is indicated for the symptomatic treatment of this manifestation.
- Deterioration of memory and mental performance in the elderly. Due to the ability of piribedil to act on dopamine receptors, the drug can be used in the symptomatic treatment of senile dementia.
- Visual impairment due to cerebral ischemia. The medicine can be useful for changing visual fields and worsening visual acuity arising from a violation of cerebral circulation.
In healthy people, the drug increases concentration, enhances alertness and improves performance. However, the medicine should not be used for this purpose. The instruction "Pronorana" warns of possible unwanted effects. This tool can be used only on the recommendation of a doctor and if indicated.
Contraindications
Not all patients can take this medication. Instructions for use of tablets "Pronoran" warns of the following contraindications:
- The medicine is not used in pediatric practice, it is intended only for adult patients over the age of 18 years.
- The active component of the drug can penetrate the placenta. The effect of the drug on the fetus is not currently understood. Therefore, during pregnancy, this remedy is not prescribed. Women of childbearing age are encouraged to use reliable contraception during the course of therapy. During lactation, this medicine is also not used.
- Pronoran is contraindicated in people with myocardial infarction.
- The drug should not be taken during a critical drop in blood pressure (collapse).
- The medicine is not prescribed with antipsychotic drugs. Joint reception is only allowed with “clozapine”.
- If the patient has intolerance to the active ingredient or excipients in the composition of the tablets, then you need to refuse to take the drug.
- The medicine can not be taken with intolerance to galactose, glucose and fructose. The medication contains these substances. Also, tablets should not be taken with sucrose isomaltase deficiency.
All of these contraindications are absolute. If the patient has these pathologies or conditions, it is necessary to inform the doctor about them. In these cases, the specialist will select another drug.
Unwanted effects
According to the instructions for the medicine "Pronoran", this remedy causes unwanted effects much less often than other anti-Parkinsonian medicines. However, the development of side effects is not excluded:
- Most often, the central nervous system responds to taking pills. Some patients experience dizziness, drowsiness, agitation, hallucinations. Sometimes a person suddenly falls asleep in the daytime.
- HELL may fall. Often, a sharp jump in blood pressure occurs in patients with a change in body position (orthostatic collapse).
- Symptoms from the gastrointestinal tract are usually mild. Patients complain of bloating and increased gas formation, nausea, and sometimes vomiting after eating.
- People with hypersensitivity to the ingredients of the tablets may develop skin allergies.
- In patients with Parkinson's disease, treatment may lead to the development of behavioral disorders: hypersexuality, overeating, gambling, a tendency to make rash purchases.
Undesirable effects are usually temporary. With a decrease in dosage or a complete withdrawal of the drug, side effects disappear.
If the recommended dose is exceeded, nausea and vomiting occur. However, this is not due to gastrointestinal tract damage, but to the effect of pyribedil on the vomiting center of the brain. In addition, with an overdose, there are sharp jumps in blood pressure. In such cases, it is necessary to urgently stop taking the drug and conduct symptomatic treatment of intoxication.
How to take medicine
Instructions for use "Pronoran" recommends taking the medicine after a meal. If this tool is used as the only drug for Parkinson's disease (monotherapy), then it is prescribed 150-250 mg per day. This dose is divided into 3 parts and taken three times a day. However, most of the drug is consumed in the morning and afternoon. For example, if the doctor prescribed a medicine at a dose of 250 mg per day, then take 100 mg after breakfast and lunch, and 50 mg after dinner.
According to the instructions, Pronoran tablets can be taken together with Levodopa as part of a complex treatment. In this case, a lower dosage is used: 50 mg three times a day.
If the drug is prescribed for other indications (not from Parkinson's disease), then it is taken 50 mg 1 time per day. In the absence of effect, an increase in the daily dose to 100 mg is allowed.
During the course of treatment, the dosage is recommended to be increased gradually, by 1 tablet every 2 weeks.
special instructions
The instruction of the drug "Pronoran" warns of such a side effect as increased drowsiness, and sometimes sudden falling asleep. In this regard, during the course of treatment, it is better to refuse to drive a car. If drowsiness is pronounced, then it should inform your doctor. You may need a dose reduction of the tablets.
This medicine is often used in the treatment of elderly patients. Side effects such as drowsiness and lowering blood pressure can trigger a fall and possible trauma. This must be remembered when taking the drug.
Instructions for use "Pronoran" also reports on possible deviations in the behavior of patients during therapy. This applies to drive disorders: increased libido, a tendency to overeat and gambling. It is necessary to warn patients and their guardians about the possible effects of the drug on the psyche. If such violations occur, you need to reduce the dose of the drug or completely cancel it.
The instruction "Pronorana" warns of the incompatibility of this medicine with alcohol. Ethanol can cause a sharp increase in side effects. During the entire course of therapy should completely refrain from drinking alcohol.
Interaction with other drugs
The use of Pronoran is incompatible with treatment with antipsychotic (antipsychotic) drugs. These drugs act on the body in the exact opposite. Pyribedil is an agonist of dopamine receptors, and antipsychotics are antagonists.
In some patients, antipsychotics cause extrapyramidal disorders. This is expressed in trembling hands, motor inhibition, impaired muscle tone. This side effect of antipsychotics resembles Parkinson's disease. Therefore, anti-Parkinsonian drugs are often used to relieve extrapyramidal disorders. However, Pronoran is not suitable for the treatment of such disorders.
In addition, pyribedil reduces the therapeutic effect of taking antipsychotics. These drugs are prescribed in the treatment of disorders accompanied by delusions and hallucinations. Dopamine receptor agonists can exacerbate psychosis.
However, there are times when a patient taking piribedil needs to undergo treatment with antipsychotics. Instructions for the drug "Pronoran" recommends in this case to stop taking the antiparkinsonian drug. This should be done gradually, regularly reducing the daily dose. It is impossible to abruptly stop taking the tablets, as severe withdrawal syndrome may occur.
It is not recommended to take pyribedil together with the medicine for hyperkinetic disorders "Tetrabenazine". These funds have the opposite effect on the body.
The instruction "Pronorana" also reports the undesirability of taking this drug along with any sedative drugs: tranquilizers, anti-anxiety antidepressants, etc.
Storage and price
Special storage conditions for tablets are not required. The drug can be used within 3 years from the date of release. Such an expiration date is indicated in the instructions for use of Pronoran.
The price of the drug in the pharmacy network is from 500 to 550 rubles. The drug is released strictly according to the prescription, since it can be taken only as directed by a doctor.
A brief overview of analogues and prices
Patients are often interested in analogues at a cheaper price. However, it is impossible to choose a tool with the same composition. The drug component of the tablets is pyribedil, as reported by the instructions for use. Analogues of Pronoran for the active substance do not currently exist.
You can choose drugs with a similar therapeutic effect, but with a different composition. These medicines include:
- "Bromocriptine."
- Parlodel.
- "Bromegon".
- Cyclodolum.
- Midantan
- Amantadine.
- Azilekt.
- "Cinema".
- Vinpotropil.
- "Phenotropil".
- Yumex.
- Eldepril.
- Madopar
These drugs are also used in the treatment of Parkinson's disease. However, each medicine has its own characteristics. To compare different medicines, you should carefully study the instructions for use of Pronoran and reviews of analogues. It is also important to remember that you can replace the drug only after consulting a doctor. It is unacceptable to use analogues on your own, most of them are prescription drugs.
The preparations Bromocriptine, Parlodel and Bromegon contain ergot alkaloids. This substance is also a stimulant of dopamine receptors. In addition, such drugs act on the pituitary gland and reduce the production of the hormone prolactin. Therefore, they are used not only for the treatment of Parkinson's disease, but also in endocrinology. The price of these drugs is from 260 to 500 rubles.
"Cyclodolum" is a fairly old anti-Parkinsonian drug. Its principle of action is different from that of Pronoran. This medicine has anticholinergic activity and can cause unpleasant side effects: dry mouth, blurred vision, and difficulty urinating. For this reason, the drug is rarely used at present. The disadvantages of this medication include its ability to be addictive and addictive. It cannot be used for long-term therapy. The price of Cyclodol in pharmacies is from 30 to 90 rubles.
Sinemet and Madopar medicines contain levodopa. They effectively eliminate trembling of the extremities, motor inhibition, muscle rigidity. But at the same time they can cause hyperkinesis (abnormal movements). Piribedil is much less likely to lead to such phenomena, in any case, as stated in the instructions to the Pronoran. Analogs with levodopa are in pharmacies from 600 to 1500 rubles.
Amantadine and Midantan are antiviral drugs that simultaneously stimulate dopamine receptors. These drugs have a fairly extensive list of contraindications, they can not be used for diseases of the thyroid and prostate glands, epilepsy, glaucoma. These are inexpensive medicines, they cost from 50 to 150 rubles.
The medicines Uumex, Eldepril, Azilekt also stimulate dopamine receptors, but at the same time they affect the metabolism of serotonin. For this reason, they are not compatible with all drugs. They can not be taken together with many types of antidepressants, as well as with drugs that stimulate the sympathetic nervous system. They also enhance the side effects of drugs containing levodopa. The cost of these drugs is high - from 1000 to 3000 rubles.
Vinpotropil and Fenotropil preparations are not always a full replacement for Pronoran. Instructions for use and reviews of analogues report that these medicines have nootropic activity. They improve cerebral circulation. These drugs are effective for Parkinson's disease of vascular origin, but they do not help much with pathology of a different genesis. Nootropics are not able to quickly eliminate limb tremors and other kinetic disturbances. They can only affect the cause of the disease if the pathology occurs as a result of damage to the vessels of the brain. The cost of Vinpotropil is from 150 to 350 rubles, and Phenotropil is from 500 to 800 rubles.
Drug Reviews
Today you can find different reviews about Pronoran. This medicine for Parkinson's disease is most often taken by elderly patients. In old age, there is often an increased sensitivity to medications, as well as concomitant diseases. For this reason, you can find many reports of the development of side effects during the course of treatment.
Patients note the effectiveness of the drug. It must be remembered that Parkinson's disease has a chronic course, and it is impossible to cure the pathology to the end. Pronoran only helps to alleviate symptoms and stop the further development of the disease.
In the reviews of Pronoran, it is reported that, against the background of the course of treatment, the patients trembled significantly, and the speech became more intelligible. Patients improve motor activity, but there is no dyskinetic disturbance. Before using the medicine, many patients had difficulty moving around even within the apartment. However, after taking the pills, their gait improved significantly, and older people were even able to take walks and practice gymnastics. Some patients noted that after regular use of the drug, their vision improved.
However, the drug often causes drowsiness. Instructions "Pronoran" and reviews report such a side effect. Sometimes patients fall asleep right on the go. Especially often, this undesirable effect occurs in the first weeks of treatment. As the body adapts to the drug, drowsiness disappears, but in some cases a dose reduction is required.
Relatives of patients sometimes report in their comments about hallucinations and changes in the behavior of elderly patients after taking the medicine. Blood pressure spikes may also occur. Hallucinations and aggressive behavior of patients sometimes persist even a few days after discontinuation of the drug. In these cases, you must visit a doctor. In some patients, such phenomena disappear after lowering the daily dosage. But sometimes a review of the treatment regimen and replacement of Pronoran with another drug is required.
This medicine is used not only in the treatment of Parkinson's disease. There are reports on thematic forums about the experience of using Pronoran for senile dementia. , , .
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