"Albendazole": instructions for use, comparison of analogues, reviews

This article will present instructions for use with Albendazole.

It is one of the most effective drugs used in the treatment of helminthic infestations. The effect on the body is sparing, so you can take it at any age. "Albendazole" should be taken orally, which ensures the highest possible effect from its use.

Description of the drug

In accordance with the instructions for use in the suspension "Albendazole", the main active ingredient in the composition of the drug is albendazole. Its action is aimed at removing parasites from the body such as helminths.

The following substances were used as auxiliary substances in the preparation: lactose monohydrate, corn starch, film coating mixture, sodium lauryl sulfate, magnesium stearate, povidone, anhydrous silicon dioxide, gelatin, talc, methyl paraben, propyl paraben.

The only pharmacological form of the drug is tablets. Albendazole tablets are round, biconvex, covered with a white film coating. Each carton package includes instructions for use and one blister with three pills.

Principle of exposure

According to the instructions for use, "Albendazole" acts as follows:

1. When ingested, the active substance provokes the occurrence of degenerative changes in the intestinal cells of parasites. With the suppression of tubulin polymerization, destruction of the cellular cytoplasmic microchannels of the digestive system of the parasite is observed.
2. The drug contributes to a change in biochemical processes.
3. The medicine after taking slows down the utilization of glucose. Its main components inhibit the synthesis of ATP.
4. There is a slowdown in the movement of secretory granules and other organs, which leads to the death of the parasite.
5. "Albendazole" is highly effective against cystodes and nematodes.

Pharmacological effects

To begin, consider the instructions for use of "Albendazole" for humans. It is necessary to take this medication in conjunction with fatty foods. Foods saturated with fats increase the absorption of the main substance in the gastrointestinal tract. A certain amount of the main active ingredient is transformed into sulfoxide, which is a primary metabolite.

Instructions for use "Albendazole 10" for animals is presented below.

The drug has anthelmintic activity. Against the background of its intake, active substances are actively distributed throughout the tissues of the whole organism.

The maximum concentration of the main active substance in the body is observed 2-5 hours after the drug was taken.

The components are excreted from the body as primary metabolites through bile. A small part is excreted with urine.

The drug fully copes with parasites that live in the intestines and in the tissues of the body. "Albendazole" is highly effective in the treatment of capillariosis and neurocysticercosis. Impaired renal function in a patient has absolutely no effect on the mechanism of action of the medication.

Indications for admission

In accordance with the instructions for use with Albendazole, it can only be taken if there are certain indications. It is recommended in the presence of diseases such as opisthorchiasis, giardiasis, filariasis, hookworm infection, microsporidiosis, toxocariasis, ascariasis, echinococcosis, cysticercosis.

In addition to these diseases, the drug will be effective in the treatment of neurocysticercosis, accompanied by CNS lesions in pork chain. The medicine can be used in relation to enterobiasis resulting from exposure to pinworms.

It is highly effective in combating trichocephalosis resulting from infection with a whipworm. Judging by the instructions for use "Albendazole" for animals, the suspension is often used as tablets.

Contraindications

Taking the drug is contraindicated in the presence of the following contraindications:

1. Hypersensitivity to any of the components that make up the medication.
2. Leaking infectious disease.
3. The acute form of fascioliasis.
4. Retinal diseases
5. Cirrhosis of the liver.
6. Phenylketonuria.
7. Depressed bone marrow hematopoiesis.
8. The period of pregnancy and breastfeeding.

Before taking "Albendozole", it is necessary to take into account all the contraindications available to the patient. This will prevent the occurrence of side effects and unwanted reactions of the body.

Adverse events when taking

According to the instructions for use and reviews of "Albendazole", an incorrect treatment regimen with the drug, as well as its use in the presence of contraindications, can provoke the development of undesirable consequences. Among these manifestations that occur while taking the drug, the following:

1. On the part of the heart and blood vessels, side effects can manifest themselves in the form of the development of tachycardia, an increase in blood pressure.
2. From the side of the central nervous system, headaches, insomnia, drowsiness, confusion, disorientation, anxiety, hallucinations, and convulsions can occur.
3. On the part of the liver and gastrointestinal tract, the appearance of dry mouth, stomatitis, diarrhea, pain in the abdomen, vomiting, nausea, and constipation is not ruled out.
4. The hepatobiliary system can respond with a transient increase in the activity of liver enzymes, the appearance of hepatitis and jaundice.
5. Hematopoietic system. "Albendazole" can cause the development of thrombocytopenia, anemia, neutropenia, pancytopenia, leukopenia.
6. The urinary system and kidneys can respond with impaired performance, proteinuria, the development of renal failure.
7. On the skin, a rash, itching, dermatitis, edema, urticaria, alopecia areata, and hyperemia can occur. So it is said in the instructions for use to "Albendazole."

In addition to these undesirable effects, the medication can also provoke general disorders of the body, which manifest themselves in the form of fever, weakness and tenderness in the bones. In rare cases, an increase in sensitivity is noted, which in turn leads to an anaphylactic reaction.

Dosage and route of administration

In the treatment of filariasis, the drug should be taken twice a day at 400 mg. The duration of treatment for this disease is 10 days.

Therapy of neurocysticercosis and echinococcosis suggests the following dosage regimen. For patients weighing less than 60 kg, the dosage should be calculated taking into account the formula - for each kilogram of body weight, 15 mg of Albendazole should be taken. In this case, the reception is carried out twice a day. With a patient's body weight of more than 60 kg, it is recommended that the medication be taken twice a day in a standard dosage of 400 mg. The course of treatment for echinococcosis is 4 weeks. After a short break, it is advisable to repeat the course. Maximum effectiveness can be achieved by passing only three courses of therapy. The duration of treatment for neurocystercosis can be from 8 to 30 days.

Therapy of ascariasis, trichocephalosis, enterobiosis and hookworm infection. Patients weighing more than 20 kg are recommended to take a single dose of the drug in a dosage of 400 mg. If the need arises, you can take a similar dose of Albendazole no earlier than after 14-21 days. With a patient weighing more than 20 kg, a single dose of the drug in a dosage of 200 mg is recommended.

Treatment of entercolitis and toxocariasis. Entercolitis therapy involves a single dose of the drug in a dosage of 400 mg. With toxocariasis, medication is taken twice at the same dosage. The course of treatment in this case takes 5 days. If treatment of toxocariasis is ineffective, experts recommend increasing the duration of the course of treatment to 20 days.

With strongyloidosis, it is recommended to take one tablet twice a day. The duration of treatment is one week.

When dealing with pulmonary flukes, the dosage is calculated taking into account the patient's body weight. You should take 10 mg of the drug per kilogram. The course of therapy is one week, tablets are taken once a day.

With cysticircrosis "Albendazole" take one tablet twice a day. When treating children, the dosage is calculated individually, also taking into account body weight. 15 mg per kilogram should be taken. The duration of treatment is 8-30 days.

Therapy of giardiasis involves taking the drug twice a day. The dosage in this case is 200 mg. A medication in childhood is prescribed at the rate of 10 mg per kilogram of body weight of the patient. The duration of treatment for giardiasis is one week.

With decaminosis, it is necessary to take the drug for 1-2 weeks at 200 mg. Reception is carried out twice a day.

With opisthorchiasis, the medicine is used at 800 mg per day. The dose must be divided into two doses. The duration of therapy is three days.

Below will be presented instructions for the use of "Albendazole" for animals.

Use for animals

Treatment of animals from parasites should be carried out, given the type of helminths:

1. Heteracidosis and ascariasis in birds are treated with the drug in a dosage calculated according to the formula - 10 mg per kilogram of bird weight. Treatment in this case should be a group.
2. Ascaridosis in pigs: 5 grams of medication should be used for every 100 kilograms of animal weight.
3. Fascioliasis: 3.75 grams of medication should be used for every 100 kg of animal.
4. Nematodes and moniesiosis in sheep: 2.5 grams per 100 kilograms of weight are expected to be used.

This indicates to the means of "Albendazole" instructions for use for animals.

Drug overdose

Exceeding the dose can cause an overdose. Symptoms of an overdose of this drug in humans are as follows: respiratory distress, jaundice, tachycardia, visual hallucinations, diarrhea, dizziness, drowsiness, nausea, and vomiting. The occurrence of these phenomena is the basis for immediate gastric lavage. Treatment is symptomatic.

What else does the instructions for use with Albendazole 10 for animals tell us ? The medicine is given taking into account the weight and degree of parasite damage, and then they monitor the reaction.

The use of the drug for the treatment of children

The medication is acceptable for use in children under 3 years of age. The dosage of the drug and the duration of the course of treatment are determined by the pediatrician, taking into account the body weight of the child, individual characteristics and the presence of contraindications.

So it is said in the instructions for use of "Albendazole" for children.

Interaction with other drugs

"Albendazole" is able to significantly increase the concentration in the blood of many drugs. Therefore, the parallel intake of this medication and other drugs should be agreed with the attending physician.

This confirms the instructions for use to "Albendazole".

Analogues of a drug

Among the most commonly used analogues of the drug, the following can be distinguished: Vormil, Gelmadol, Aldazol, Zentel, Sanoksal, Nemozol, Gelmodol-VM, Mebendazol, Vermox, Pirantel "," Medamine. "

Albendazole and Vermox - which is better?

Vermox is an analogue of Albendazole. The course of therapy "Vermoxom" involves the parallel intake of sorbents necessary for the rapid removal of helminths. At treatment "Albendazoleum" reception of sorbents is not required. It is worth noting that Vermox has much less indications for use than Albendazole.

Albendazole and Pirantel

"Pyrantel" is an anthelmintic drug that causes in the body of worms to block the transmission of nerve impulses, which provokes their death. Reception of "Pirantel" is allowed from birth. Albendazole has a different mechanism of action, but its effectiveness has been proven. It is worth noting that Pirantel causes side effects in lesser amounts than Albendazole.

Reviews on the drug "Albendazole"

Patients who underwent treatment with the drug "Albendazole" leave mostly positive reviews, since the drug is really effective in controlling parasites. It acts on the body gently, and concomitant use of laxatives is not required.

Some patients report side effects. Most often, headaches, weakness, and nausea occur. However, such symptoms are manifested to a greater extent not from taking the drug, but from toxins that are released during the death of parasites. "Albendazole" is effective against almost all types of human parasites.

Therapy with this tool is very effective - a person begins to feel much better after taking the first dose. Nervousness and irritation are reduced, there is a surge of strength and energy.

Use the drug only as directed by a competent doctor. This is due to the fact that the treatment of a particular type of parasite requires a certain dosage.

We reviewed the instructions for the use of "Albendazole" in veterinary medicine, as well as for humans.