For people suffering from diseases of bones, joints and muscles, doctors often prescribe Nimid (tablets) as symptomatic therapy. Instructions for use contain information that this drug not only relieves pain, but also has an anti-inflammatory effect. Let's try to study the characteristics of the drug in more detail and figure out in which cases it can help.
Forms of medicine and their composition
As for the forms of the medicine, today in pharmacies you can buy tablets, suspension, granules and gel. The main active ingredient in them is nimesulide. The tablet form of the drug is available in blisters of 10 pcs. One tablet contains 100 mg of nimesulide, and pharmacists used microcrystalline cellulose, sodium stearate, croscarmellose sodium and Aerosil 200 as auxiliary components. This is the information on the use of the drug “Nimid” (tablets).
Powder is available in dosed sachets. This form of the drug is convenient to use for the treatment of children. Indeed, in addition to nimesulide, povidone K-30, tabletose 80 and Aerosil 200, such auxiliary substances as sodium saccharin, citric acid and flavoring additives are contained. The baby will drink the delicious healing “cocktail” prepared by the parents with pleasure.
In 1 ml of suspension and 1 g of gel contains 100 mg of nimesulide. As auxiliary components in these two forms, propylene glycol, sodium hydroxide, carbomer 940, disodium edelate, flavoring agent, purified water and methyl paraben were used.
Pharmacological action of the drug
Nimesulide, which is the active substance of this medication, belongs to the group of non-steroidal anti-inflammatory sulfonanilides. Once in the human body, it selectively inhibits COX-2 and inhibits the synthesis of prostaglandins in the focus of the inflammatory process. Analgesic, antipyretic and anti-inflammatory effect is achieved after taking one "Nimid" -tablets. Instructions for use contain more information regarding the dosage of the drug.
In addition to all of the above, the drug is able to inhibit the release of oxygen free radicals and inhibit the release of myeloperoxidase, while it does not affect the processes of phagocytosis and chemotaxis.
As for the anti-inflammatory effect of the drug, it is achieved due to the ability of nimesulide to suppress inflammatory mediators and reduce tumor necrosis factors. By inhibiting the synthesis of interleukin-6 and urokinase, the Nimid preparation (instructions for use confirms this fact) prevents the destruction of proteoglycans and collagen of cartilage tissue. In addition, nimesulide blocks the nociceptive system of pain impulses.
If we consider the mechanism of analgesic action, it is associated with inhibition of the release of histamine from numerous mast cells and the effect of the active substance on glucocorticosteroid receptors.
If the doctor has prescribed Nimid (tablets), the instructions for use should be carefully studied before taking the medicine. After all, this document contains recommendations that must be taken into account throughout the course of therapy.
Pharmacokinetics
After taking the recommended dose, the drug is actively absorbed from the digestive tract. And after 1.5-2.5 hours, the maximum concentration of the active substance in the blood plasma is noted. A characteristic feature of the drug is its high ability to interact with proteins, as well as to penetrate the blood-brain and blood-brain barriers. In high concentrations, nimesulide is determined in the focus of the inflammatory process and in the synovial fluid.
The metabolism of the drug occurs in the liver, then, for the most part, in the unchanged form of active metabolites, it is excreted through the kidneys (with urine), and less - with feces. The half-life of the active substance is achieved after 3.5-5 hours. It contains more specific pharmacokinetic data on the drug "Nimid" instructions for use.
Indications
An effective drug for fever, which accompanies diseases of the ENT organs and upper respiratory tract. Quite often, the drug is prescribed for people suffering from rheumatoid arthritis, myalgia, osteoarthritis, bursitis, tendonitis, as well as other diseases of the muscles, joints and bones, accompanied by pain. In dental and gynecological practice for postoperative and post-rheumatic pains, the Nimid medication is also used. Instructions for use in such cases recommends the purchase of tablets, powder or granules.
As for the drug in the form of a gel, it is intended for local use in inflammation of tissues (soft) that are caused by various injuries. The remedy is also effective for inflammatory processes and degenerative ailments of the musculoskeletal system, osteoarthritis, ankylosing spondylitis , etc. It contains an extended list of indications for the use of Nimid, an instruction for use from the manufacturer.
Admission Conditions and Dosing System
If we are talking about taking medications in the form of tablets, suspensions, then you need to use it only after eating. It is desirable that after eating at least 20 minutes have passed, otherwise the pharmacokinetic effect of nimesulide slows down. As for the dosage of the drug and the duration of the course of treatment, the attending physician should answer these questions directly, taking into account the individual characteristics of the patient and the severity of the disease. Therefore, we consider only the general recommendations that the instructions for use contain about the Nimid medicine.
Tablets for adults are usually prescribed twice a day at 100 mg. In severe forms of the disease, the daily dose can be doubled. Adolescents from 12 to 18 years old are recommended to calculate the dosage of the drug at the rate of 1.5 mg per 1 kg of body weight. If treatment is required for a child under the age of twelve, and his weight exceeds 40 kg, he is prescribed 100 mg of the drug per day, dividing the norm into two doses. In exceptional cases, the doctor may increase the recommended dose.
The tool in the form of granules is prescribed for children from 12 years old and adults for 1 sachet in the morning and evening. The contents of the bag are diluted in 100 ml of warm water and drunk after meals.
As for the Nimid gel, it is applied no more than 4 times a day with a thin layer (without rubbing) on a part of the body with the most pronounced pain syndrome. After using the medication, wash your hands thoroughly with soap under running water.
To whom is the drug contraindicated?
Do not prescribe a medicine for people with peptic ulcer, severe disorders in the liver and kidneys, as well as with hepatotoxic reactions to nimesulide in history. The drug is categorically contraindicated with a tendency to various bleeding, heart failure and hypersensitivity to one or more components of the Nimid Forte medication. The instructions for use also contain information on the prohibition of the use of the drug in combination with potentially hepatotoxic drugs, with fever, flu-like conditions and suspected surgical acute pathology.
As for the gel form, it is not prescribed for patients under 12 years of age and for people prone to allergic reactions. The use of the medication can aggravate the course of the disease with dermatitis, damage and skin infections, as well as bronchial asthma, which is caused by ASA. That is why with the above pathologies, the Nimid remedy is not prescribed. Instructions for use of the tablet in such cases also do not recommend use.
Can I take medicine during pregnancy?
Scientists have found that nisumelide is able to affect fertility. In addition, it inhibits the synthesis of prostaglandins, which, as you know, can cause the development of low water, pulmonary hypertension, oliguria and premature narrowing of the Batalov duct. The risk of weakening labor, peripheral edema and bleeding when using the Nimid medication may increase. Instructions for the use of tablets and other forms of medication categorically prohibit both during pregnancy and during lactation.
After all, the active substance along with breast milk can enter the baby’s body and disrupt the functioning of its vital systems. In those cases where it is impossible to do without medication, and the benefit to the mother exceeds the risk of harming the baby, the doctor determines the dosage and course of therapy.
Side effects
In addition to the mass of positive pharmacological characteristics, the drug has an impressive list of side effects. So, let's see what reactions can occur when using Nimid. Tablets (an instruction in Russian provides this data) can cause itching, hives, various skin rashes, angioedema, and in some cases even Stevens-Johnson syndrome and epidermal necrolysis. The gastrointestinal tract can, in turn, respond to the medicine with constipation, diarrhea, sometimes patients have pain in the stomach, nausea. Very rarely, taking pills can cause ulcer perforation and peptic ulcer of the stomach and duodenum.
Since the metabolic process occurs in the liver, it also suffers from this. Therefore, long-term administration of the drug in some cases can cause a change in the activity of transaminases, cholestasis, the development of jaundice and even acute hepatitis. Not only tablets and granules cause the same disturbances in the liver, but also Nimid powder.
The instruction specifically describes the possible reactions of the genitourinary system when taking the medicine. It can be both edema, dysuria, urinary retention, and oliguria, acute renal failure, interstitial nephritis. From the respiratory system, dyspnea and bronchospasm are possible, prolonged use can cause the development of bronchial asthma.
In addition to the above effects, the patient may develop tachycardia, arterial hypertension, hypothermia, asthenia and other diseases. In almost all adverse reactions, it is recommended to discontinue the medicine and consult a doctor immediately. In order not to be in such a situation, it is necessary to carefully study all the possible information about the drug and only then take "Nimid Forte" (tablets). Instructions for use, which is in every package of the medicine, will help with this.
Drug overdose and first aid algorithm
If the admissible dose of the drug was accidentally exceeded, you must immediately go to the hospital. After all, the consequence of such a mistake can be drowsiness, nausea, vomiting, pain in the espigastrium, apathy, increased blood pressure. And this is a list of only the most mild reactions of the body to an increased dose of the Nimid drug. Pills, - the instruction warns about this - taken in an amount of 2-3 pieces above the permissible norm, can cause internal bleeding, as well as lead to renal failure. In medical practice, rare cases of anaphylactoid reactions, respiratory depression and coma due to an overdose of this drug have been recorded.
If the permissible dose is exceeded, it is not worth waiting for clinical manifestations. It is necessary to immediately wash the stomach, take osmotic laxative and enterosorbents. After the above measures, it is advisable to go to the hospital, where specialists will continue symptomatic treatment. It is worth noting that today there is no specific antidote.
What do patients think about the drug?
Of course, in diseases with acute pain syndrome, almost all patients respond well to the medication we are considering. They note that the effect of taking the drug comes fairly quickly, which is good news. Quite different comments can be heard when patients were prescribed a long course of therapy with Nimid. Tablets (the instruction recommends paying special attention to this pharmacological property of the drug) quickly relieve pain, but after a few days of taking side effects come to light. The first to react to the gastrointestinal tract nimesulide, later the nervous system (this manifests itself with irritability, rapid mood swings and a tendency to apathy).
Of course, it is impossible to categorically say that a medicine does more harm than good. After all, it really helps. But taking it without evidence and the appointment of a specialist is not recommended.
If after the above information there are doubts about whether to buy Nimid (tablets), the instructions, patient reviews and the advice of your doctor will help you make the right decision.