What is the medicine "Tinidazole"? What does this medicine cure? You can find answers to these questions in this article. It will also provide information on whether the drug in question has analogs, what patients leave reviews about it and how much it costs in pharmacy chains.
Form of release of the drug, its packaging, composition
What form is inherent in Tinidazole? Reviews say that this drug is produced in the form of tablets, which are coated with a special shell.
The main ingredient of this medication is tinidazole. Also, its composition includes additional elements, which are presented in the form of alginic acid, microcrystalline cellulose, magnesium stearate, sodium lauryl sulfate and starch.
As for the tablet shell, it consists of titanium dioxide, propylene glycol and hydroxypropyl methylcellulose.
The drug "Tinidazole", the instruction of which is contained in a cardboard box, is packaged in blisters for 4 tablets.
Basic properties
What is tinidazole? What does this remedy cure? According to the instructions, this drug refers to antiprotozoal drugs that exhibit pronounced antibacterial properties.
The principle of action of this medication is based on DNA damage and inhibition of the multiplication of pathogens. It is particularly effective against organisms such as Entamoeba histolytica, Lamblia intestinalis and Trichomonas vaginalis.
It should be noted that the drug in question has a bactericidal effect against anaerobic bacteria.
Kinetic indicators
The drug "Tinidazole", the price of which is presented at the end of the article, has a high degree of absorption. Its bioavailability is 100%.
The relationship of the drug with plasma proteins reaches 12%. The peak concentration of tinidazole in the blood after oral administration is observed after two hours and is approximately 40-51 ฮผg / ml. After another day, it is about 11-19 ฮผg / ml, and after 72 hours - 1 ฮผg / ml.
The drug in question penetrates the placental and BBB through the barrier. It is also excreted in mother's milk within 72 hours after administration.
The metabolism of the drug occurs in the liver. In this case, pharmacologically active hydroxylated derivatives are formed that inhibit the growth of anaerobic bacteria and enhance the effect of tinidazole.
The half-life of the drug in question is 12-14 hours. About 50% of the drug is excreted with bile. Through the kidneys, this remedy is excreted in the amount of 12% (in the form of derivatives) and 25% (unchanged).
Tinidazole medication: what is it treating for?
The following diseases are indications of this drug:
- trichomoniasis;
- prevention of anaerobic infections (postoperative);
- giardiasis;
- Helicobacter pylori eradication (in combination with antibiotics or bismuth preparations) ;
- amoebiasis (including hepatic form);
- mixed aerobic-anaerobic infections (in combination with antibiotic agents);
- infections caused by anaerobic bacteria.
Prohibitions for receiving funds
Now you know what the medicine โTinidazoleโ is. What this medicine cures of, we also described above.
According to the instructions, the medication in question has contraindications. These include the following conditions:
- disorders in the process of hematopoiesis;
- organic diseases of the central nervous system;
- first trimester of pregnancy;
- breast-feeding;
- hypersensitivity to tinidazole and other derivatives of 5-nitroimidazole.
The drug "Tinidazole": instructions for use
The tablets in question are intended for oral administration only. Usually, their dosage is calculated individually, depending on the nature of the disease and patient tolerance to the drug.
For adults, this medication is prescribed in a dose of 1.5-2 g once a day. As for babies (but not for the prevention of anaerobic postoperative infections), they are recommended to use 50-75 mg / kg once a day.
The duration of treatment with this agent is determined by the doctor and can be about 2-10 days.
Side effects
The drug "Tinidazole" from fungus and other infections can cause the following negative effects:
- CNS and PNS: dizziness, dysarthria, headaches, excessive fatigue, convulsions, impaired coordination of movements, peripheral neuropathy, weakness.
- Alimentary tract: diarrhea, anorexia, dry mouth, nausea, metallic taste in the mouth, vomiting.
- Allergy: urticaria, skin rash, itching, angioedema.
- Other: transient leukopenia.
Drug Interactions
Can I take Tinidazole with other medicines? Reviews claim that with the joint use of the drug in question and ethanol, the development of a disulfiram-like effect is possible.
Lactation and pregnancy
The drug "Tinidazole" is contraindicated in the first trimester of pregnancy. The use of the medication in the second and third trimesters is possible only if the intended benefits for the future mother in labor outweigh the risk for the baby.
If this tool must be taken during breastfeeding, it is necessary to solve the issue of stopping lactation. As you know, tinidazole is determined in mother's milk within 72 hours after its administration.
Special recommendations
In the treatment of a disease such as trichomoniasis, it is necessary to simultaneously treat both partners.
In the process of taking the drug should refrain from drinking alcoholic beverages.
If side effects from the central nervous system appear, the medication is canceled.
When taking tinidazole, urine may turn dark.
If the patient's treatment lasts more than 6 days, then it is necessary to constantly monitor the blood picture.
For the prevention of anaerobic infections (postoperative), the dosage of the drug for children under 12 years of age has not been established.
During the treatment period, the agent under consideration should refrain from engaging in hazardous activities.
Price, analogues, consumer reviews
How much do Tinidazole tablets cost? The price of this medicine is approximately 30 rubles. For modern consumers, this cost of the drug is quite acceptable.
What can replace the Tinidazole medication? We will list the analogs of this remedy right now: Tiniba, Fazizhin, Vero-Tinidazole and Tinidazole-Acre.
Reviews about this medicine are mostly positive. Patients claim that this drug fights well with giardiasis and trichomoniasis. However, some consumers report that Tinidazole very often causes nausea, vomiting, and dizziness.