Trental is a medicine designed to enhance blood microcirculation. It is available in the form of tablets, injection.
How does Trental work? The description of the drug reports that pentoxifylline is its active ingredient. This substance is a derivative of xanthine, a purine base present in all body tissues. Pentoxifylline actively reduces the aggregation (clumping) of red blood cells, increases their elasticity, thereby reducing blood viscosity. It reduces the accumulation of fibrinogen in plasma, normalizes fibrinosis. Trental helps the accumulation of adenosine monophosphate in myocytes of the walls of blood vessels, reduces vascular resistance, but increases systolic volume, without changing the number of heart contractions.
In addition, Trental, the description of the drug contains this information, accelerates the metabolic processes occurring in the nervous system, significantly multiplies the volume of adenosine triphosphoric acid in the brain cells. The medicine normalizes bioelectric activity indicators.
Who needs Trental treatment? Indications for use are based on the ability of the drug to improve microcirculation.
It is prescribed for the treatment of:
- Encephalopathy caused by atherosclerosis, a violation of cerebral circulation.
- Dyscirculatory encephalopathy.
- Stroke (ischemic).
- Vascular impotence, other sexual problems associated with circulatory disorders.
- Paresthesia.
- Raynaud’s disease.
- Trophic ulcers, frostbite, gangrene, skin lesions associated with an insufficient amount of incoming blood.
- Bronchial asthma, emphysema, bronchitis.
- Hearing loss caused by circulatory disorders.
- Loss of vision caused by inadequate blood circulation.
- Other circulatory disorders, especially provoked by inflammation, diabetes, atherosclerosis.
Treatment with the drug should be prescribed only by a specialist, because Trental, the description of the drug contains this information, can cause side effects.
These include:
- Stomach pain, cramping, nausea, upset stool, vomiting. The occurrence of gastric bleeding due to the use of Trental is not proven.
- Heart rhythm disturbance, palpitations, tachycardia, angina attacks, hypofibrinogenemia, hyperemia.
- Anxiety, panic attacks (rare), irritability, sleep disturbance, drowsiness, dizziness. Rare cases of aseptic meningitis have been noted (with ultra-high doses or an unreasonably long course of treatment).
- Quincke's edema, rash, anaphylactic shock.
In order to avoid such consequences, it is necessary to take Trental only as prescribed by the doctor, after a thorough examination.
Trental, a description of the drug in detail reports this, is not shown to all patients with the above diagnoses. There are categories of patients who are not recommended to prescribe this medicine.
People prone to bleeding, suffering from hemorrhagic heart attacks or hemorrhages are not recommended to use Trental. Contraindications also apply to pregnant and lactating, children, people with drug intolerance.
An overdose of the drug can be fatal. With the introduction of ultra-high doses, the development of gastric bleeding, vomiting, tachycardia was noted. Often, especially after injections exceeding the dosage, excitement, anxiety, loss of consciousness, and convulsions were observed.
In this case, it is necessary to carry out an urgent gastric lavage, conduct therapy, focusing on the symptoms that have arisen. Mandatory control over the vital functions of patients.
The dosage of the drug, the choice of dosage forms, the duration of treatment are determined only by the attending specialist, focusing on the diagnosis and characteristics of the patient.