This article will present instructions for use with Suprastin.
This antihistamine is a clinical and pharmacological group of drugs - N-histamine receptor blockers. Such substances have a pronounced therapeutic anti-allergic effect and are used, as a rule, to reduce the manifestation of allergic reactions with various effects on the body from the outside, that is, when allergens of various origins get inside.
What does the instruction for Suprastin tell us?
Dosage forms and composition of the medicinal product
This medication is available in two main dosage forms, which are presented in tablets and solutions for intramuscular administration.
Suprastin tablets have a round shape, white color, a flat cylindrical surface. The main active ingredient of this drug is chloropyramine, the content of which in one tablet is 25 milligrams.
According to the instructions for “Suprastin” for allergies, in addition to the main substance, it also includes auxiliary substances, which in this case include:
- potato starch;
- stearic acid;
- lactose monohydrate;
- sodium carboxymethyl starch;
- talc;
- gelatin.
Suprastin tablets are packaged in 10 pieces per blister. A cardboard pack contains two blisters with tablets, as well as an abstract of this pharmacological preparation.
The instructions for use with Suprastin also indicate that the drug solution for intravenous as well as intramuscular administration is a clear, colorless liquid with a slight specific odor. Each ampoule is dark red with a code ring and a break point contains 1 ml of solution. Ampoules are packaged in blister packs of 5 pieces and in cardboard packs of one or two cells. In one ampoule with a solution contains the active substance - chloropyramine hydrochloride - 20 milligrams, as well as an auxiliary component - water for injection. Instructions for use with Suprastin tablets are very detailed.
Pharmacokinetics
In accordance with the instructions to Suprastin, the main active ingredient of the solution for injection and tablets (chloropyramine) is a chemically modified substance due to the addition of chlorine atoms to a derivative of the classical antihistamine compound pyribenzamine. It contributes to the blocking of H-histamine receptors, due to which they lose sensitivity to the main mediators of specific allergic reactions of histamine, which is produced in certain cells of the body as a response to the introduction of an allergen under conditions of increased sensitivity (sensitization). In addition, this compound is able to partially block M-cholinergic receptors. As a result of such physiological effects, several therapeutic actions take place at once, in particular antiemetic, antiallergic and moderate antispasmodic.
The instructions for use with Suprastin say that after taking a pharmacological agent orally (in the form of tablets), the main active ingredient is rapidly and almost completely absorbed into the blood from the intestinal cavity. After that, it begins to be evenly distributed in the tissues and penetrates into the structures of the central and peripheral nervous system through the blood-brain barrier. Chloropyramine metabolism occurs in the liver with the formation of inactive decay products excreted in the urine through the activity of the excretory system, mainly the kidneys. In children, this drug is excreted more quickly than in adult patients.
Indications for use in children and adults
According to the instructions to Suprastin, the main medical indications for the use of a medication are various clinical manifestations of allergies in humans, the list of which includes the following pathological conditions:
- Rashes on the surface of the skin, accompanied in some cases by burning and severe itching.
- Urticaria, which is a rash in the form of small itchy seals on the skin like blisters resembling a nettle burn.
- Angioneurotic edema (Quincke's edema), in which there is a marked increase in soft tissues in volumes with the primary localization of a similar manifestation of allergy in the face, larynx and external genital organs.
- Serum sickness, accompanied by fever, which develops after the introduction of immunobiological medications into the blood.
- Allergic rhinitis, which is a specific inflammatory process that affects the mucous membrane of the nasopharynx. This pathology has a year-round or seasonal course, during the flowering of certain plants.
- Food or drug allergic reactions of various localization and severity in the body.
- Itchy skin of various etiologies.
- Allergic varieties of conjunctivitis, which are a specific inflammatory process of the conjunctiva of the eyes.
- Eczema is chronic or acute, accompanied, as a rule, by the corresponding skin manifestations.
- Contact dermatitis, the occurrence of which is associated with local contacts of the skin with various types of allergens, for example, under the influence of household chemicals.
In addition, this medication is used to reduce the severity of specific allergic reactions caused by the ingestion of foreign proteins after the bites of any insects.
The instructions for Suprastin also contain information on contraindications. Let's consider them further.
Possible contraindications for use
There are some pathological and physiological conditions of the patient’s body, which are contraindications to the use of tablets and injection solution of the drug “Suprastin”. These include:
- Children under one year of age, including prematurity.
- The period of pregnancy and breastfeeding.
- An acute course of bronchial asthma with the occurrence of shortness of breath and paroxysmal cough.
What else does the instructions for use with Suprastin tell us?
Use with caution
In cases of increased intraocular pressure in the presence of angle-closure glaucoma, functional liver or kidney dysfunctions, cardiovascular pathologies, in men with prostatic hyperplasia, as well as in violation of urine excretion processes, this medication should be used with some caution, preferably under the supervision of a specialist. The same applies to the use of the drug in the elderly and children. Before you start using the injection or tablet, it is imperative that you verify the absence of the above contraindications and study the instructions for use with Suprastin.
Methods of use and dosage for adults and children
The tablets of the drug "Suprastin" are taken orally (inside). They must be taken with food without chewing and drinking plenty of fluids. This describes the instructions for use. Suprastin tablets for children are also used.
On average, the therapeutic dosage for an adult is 1 tablet 3 times a day, for children over 6 - half a tablet 3 times a day, and for children under the age of 6 years - half a tablet 2 times a day.
How to give "Suprastin" to children up to a year according to the instructions?
As a rule, a quarter of a tablet is prescribed to newborns 2 times a day, after dissolving the drug in a mixture for baby food or in breast milk. The duration of the course of treatment with the medication is determined by the disappearance of the symptoms of allergic reactions. In most cases, therapy is no more than five days, but may be less in children up to a year.
The instruction to Suprastin does not end there.
The drug in the form of injectable solutions is prescribed to patients mainly when there are pronounced allergic reactions that require quick elimination, that is, in cases of extremely acute conditions, when an almost instant effect is expected. Injections of this medication are often used for children, as well as those adults who cannot swallow a tablet due to some pathological conditions. This is confirmed by the instruction for Suprastin injections.
In other situations, as a rule, for mild allergic reactions, the drug is used in the form of tablets.
The dosage of the drug in the injections is determined by a specialist based on the age and indicators of the patient’s body weight, and this may also depend on the severity of the allergic reaction. According to the instructions for the rules for using this pharmacological drug in injections, its daily dosage for adults is 2 ml with intramuscular injection.
For children under one year of age, a single dose should be no more than 0.2 ml of the drug, and for children over this age, half the ampoule of the medicine. From 6 years to 12 years - 1 ampoule of Suprastin. The dosage of the drug for use in childhood is calculated, as a rule, at 2 mg per kilogram of body weight.
In cases where there is a need for a long course of use of the drug, injections are prescribed at the initial stages, and after the elimination of acute attacks of an allergic reaction, they usually go to the tablet form of the medication. Instructions for use with "Suprastin" warns of side effects.
Side effects
Against the background of taking pills and using injections of the suprastin medication, certain negative pathological manifestations, provoked by the action of the main active substance of the medication, from some organs and systems may occur. Such reactions include:
- Digestive system - abdominal pain, mainly in the upper sections, nausea, which is accompanied by periodic bouts of vomiting, decreased, increased or lack of appetite, upset stool in the form of constipation or diarrhea, dry mouth.
- Nervous system - periodic dizziness, excessive fatigue, tremor (trembling) of the hands, increased drowsiness, nervous excitement.
- Cardiovascular system - lowering blood pressure, heart rhythm disturbance (arrhythmia), tachycardia (heart rate).
- Urinary system - difficulty urinating.
- Red bone marrow and blood - leukopenia (a decrease in the level of leukocytes), agranulocytosis (a decrease in the number of granulocytes) in blood serum.
- Musculoskeletal system - myasthenia gravis (muscle weakness).
- Sensory organs - increased intraocular pressure.
- Skin - photosensitivity (increased sensitivity to light).
According to the instructions for use, Suprastin allergy tablets should be drunk with caution, in no case should the dosage be exceeded.
The occurrence of signs of unwanted side effects is a direct basis for stopping the use of tablets and injections of the suprastin medication and contacting a specialist who must determine the possibility of subsequent use of this medication.
Special recommendations
To "Suprastin" from allergies, the instructions for use should be studied in detail before starting treatment.
While using this medication, some special recommendations should be observed. These include:
- Pathological processes that are localized in the liver or kidneys, and are accompanied by a decrease in the functional activity of these organs. In such cases, a reduction in the dosage of the drug is required.
- With the concomitant allergic reaction of reflux esophagitis in patients, the use of Suprastin tablets and injections in the evening can cause an increase in the manifestations of a similar pathological process in the form of heartburn.
- During the course of therapy with this medicine, alcohol should be avoided, since it is possible to increase its effect, which suppresses the functionality of the nervous system.
- In patients with impaired digestion and absorption of carbohydrates in the intestine, dyspeptic disorders can occur, which, as a rule, provoke the lactose present in the composition of the tablets.
- The concomitant use of this drug simultaneously with ototoxic drugs can mask their manifestations.
- "Suprastin" in some cases enhances the inhibitory effect on the nervous system of antidepressants, analgesics, some tranquilizers, monoamine oxidase enzyme inhibitors, M-anticholinergic drugs.
- The active substance of the drug can provoke drowsiness and inhibition of the activity of the nervous system, and therefore it is not recommended to perform dangerous types of work against the background of its use, especially in the initial period of therapy.
We reviewed the instructions for Suprastin tablets for adults and children, as well as injections.
Analogues of the drug
Today, there is a huge selection of antihistamines that quickly eliminate allergic reactions and can be considered analogues of the Suprastin medication. They do not have the same composition and are similar only in therapeutic effect. These medicines include:
- "Suprostilin";
- "Chloropyramine";
- "Tavegil";
- Donormil;
- “Phenyden”;
- Normoson
- "Relip";
- "Loratodin";
- "Zodak";
- "Cetirizine";
- "Tsetrin" and others.
Analogs of Suprastin tablets are not indicated in the instructions, there is no information about analogues of injections.
Reviews about the drug
This medicine is known to almost every person, due to its long existence in the market of pharmacological preparations and the fact that this medication has established itself in the best way. There are a lot of reviews about it, and almost every one of them contains information about the high effectiveness and safety of this medical product.
Many people like simple and understandable instructions for use with Suprastin tablets.
Adult patients who left reviews about him, note that when they have allergic reactions of moderate and severe severity, this remedy helped them quickly stop such phenomena. In this case, the medication in the form of intramuscular injections was most often used. Patients were satisfied with this medication even after applying it during periods of seasonal allergies and noted that they showed a significantly reduced allergy to flowering of various seasonal plants, which include sneezing, nasal congestion, tearing, difficulty breathing and swelling of the mucous membranes. Also, patients observed a significant improvement in sleep during the use of the drug "Suprastin".
Parents of children who suffered from all kinds of allergies, both seasonal and year-round, also observed a significant improvement in their condition. However, they note that this drug is prescribed to children most often during acute allergic attacks, but is not suitable for prolonged use. The medication, according to these people, is practically indispensable in the event of severe laryngeal edema in children in the form of an allergic reaction to some irritants, including drugs, as well as for some diseases in children that are accompanied by swelling of the nasopharynx.
As adverse reactions, almost all patients noted increased drowsiness, which in some cases significantly disrupted their usual lifestyle, as well as some minor dyspeptic symptoms and stool disorders. However, the latter could be caused by other factors unrelated to the use of this pharmacological agent.
The article gave detailed instructions for tablets from allergies "Suprastin" and for injections.