Modern medicine does not stand still, it is developing rapidly. New methods of treatment of various diseases are being developed, the most effective drugs for combating ailments are being produced. One of them is a violation of the secretion of the stomach. It leads to the appearance of many concomitant diseases. The drugs "Noflux" and "Rabeprazole" are proton pump inhibitors that reduce gastric secretion. They have a similar therapeutic effect, but differ in price. Let's see how they work.
General information
Manufacturing country "Noflux" - Hungary. The main active ingredient is rabeprazole. The drug is produced in the form of tablets, coated with a membrane, soluble in the intestine. Their shape is biconvex, and the color depends on the dosage. 10 mg tablets are pink and 20 mg yellow. Inside the product is white. Norflux packs contain instructions for use and drug blisters. Each plate contains 7 tablets, and in total there can be from 14 to 28 pieces in a package.
Chemical composition
"Noflux", the composition of which in addition to the main active substance has additional ones, can be purchased at almost any pharmacy.
Related substances include:
- titanium dioxide;
- magnesium stearate;
- magnesium oxide;
- talc;
- dyes;
- ethyl cellulose and other components.
Pharmacology
The instruction for use proposed for the Noflux drug reports that its action is aimed at inhibiting the secretion of acid in the stomach, both basal and stimulated. The drug easily penetrates into the parietal cells of the stomach, where it affects the reduction of acid secretion.
The first signs of the action of the drug can be seen already an hour after its use, and the maximum effect can be achieved in 2-4 hours, while Noflux completely evens out the secretion of the stomach no earlier than 24 hours after the first dose. The action of the tablets is discontinued several days after the last dose. The drug does not affect the work of other body systems.
Pharmacokinetics
Once in the body, "Noflux", the active substance of which is rabeprazole, is almost completely absorbed, concentrating in the blood plasma with maximum levels after 3-4 hours. The main component of the drug is almost completely associated with blood proteins, and its bioavailability does not depend on the number of doses and is more than 50%.
The drug is excreted mainly by the kidneys, but a small part of the substance leaves the body through the work of the intestines.
What is it used for?
Noflux, an analogue of which can be purchased at a more affordable price, is used in a dosage of 10 mg to treat the symptoms of dispersion and GERD (gastroesophageal reflux disease). They can be sour belching, heartburn and other unpleasant sensations accompanying increased acidity of the stomach.
An increased concentration of the active substance is used already with:
- exacerbations of peptic ulcer of the duodenum and stomach;
- anastomotic ulcer;
- ulcerative GERD;
- other pathological increased secretions of acid.
Contraindications
Who can not be used for the treatment of Noflux, the instructions for use clearly stipulate. It:
- pregnant;
- nursing;
- having an intolerance to the drug or any means included in it.
A dosage of 10 mg is contraindicated to use under the age of 18 years, and 20 mg - under the age of 12 years.
With caution, the drug and all Noflux substitutes should be taken in the presence of severe renal or hepatic insufficiency or when prescribing a drug of 20 mg after the age of 12 years. In each case, you need to consult a doctor about which drug to choose.
Analogs
The analogue of Noflux can be both in terms of the main active component and in its effect on the body.
Allocate the main similar proton pump inhibitors:
- Zulbeks;
- Omeprazole;
- "Soars";
- "Emanera";
- "Hirabesol.
Benefits of the active ingredient
People often ask which is better, "Noflux" or "Omeprazole"? The answer is obvious - Noflux. First of all, its active component is safer for the body, and in the second it is more effective. To achieve the result of rabeprazole, 2 times less is required. There are a number of additional benefits. So, rabeprazole does not create a withdrawal syndrome after discontinuation of administration, and its bioavailability does not depend on the time of administration. It is more reliable and operates in a wider range, but it is much more expensive than its counterparts.
"Zulbeks", the instructions for use of which state the same indications, is analogous to the current component, so its cost is not much lower. This drug is dispensed in pharmacies without a prescription, regardless of dosage. The rest of the drug is completely analogous to Norflux.
Instruction manual
Zulbeks tablets, the instructions for use which describe all the features of the drug, like Noflux, are used to treat diseases of the stomach and intestines:
- GERD with erosive lesions;
- GERD without erosive lesions;
- exacerbation of a stomach ulcer;
- exacerbation of a duodenal ulcer;
- Zollinger-Ellison syndrome.
This is due to its similar chemical composition. Among the analogues in the active component is also included the Pariet drug, the instructions for use, the price and other features of which also do not differ from the means considered above.
All tablet preparations based on rabeprazole are taken orally, they do not need to be chewed. If you need a single dose per day, it is better to drink tablets in the morning before meals, which will contribute to optimal adherence to the regimen. The duration of admission courses depends on the disease and the individual characteristics of the body, therefore it is prescribed only by the attending physician. If necessary, the duration of therapy can reach 1 year.
Tablets with a dosage of 10 mg are dispensed in pharmacies without a prescription, but a double dose of 20 mg already requires an appropriate conclusion from a specialist.
Side effects
"Pariet" tablets, instructions for use, the price and contraindications of which are similar to "Noflux", have the same possible side effects with it. In most cases, they are not observed at all or are weakly expressed, but rarely appear in other forms.
So, can be observed:
- from the digestive system: constipation, diarrhea, flatulence, abdominal pain;
- from the immune system: allergic reactions;
- from the hepatobiliary system: jaundice, hepatic encephalopathy; hepatitis;
- skin reactions: rashes;
- nervous system: headaches, dizziness.
Peripheral edema, necrolysis, leukopenia can also occur, but all this is extremely rare. With long-term use, Noflux (an analogue of the active component - also) can provoke an increased risk of fractures.
In case of an overdose, symptomatic treatment is performed , but very few severe cases of such a reaction have been recorded.
Features of the reception
For elderly patients, dose adjustment is not required. The drug has no prohibitions on driving vehicles and controlling mechanisms, but nevertheless one should refrain from such actions, since drowsiness may develop against the background of therapy.
Before starting the course and after its completion, it is necessary to undergo a study for the presence of malignant tumors in the stomach, since taking the drug helps to mask the symptoms associated with the tumors.
Reception during gestation
According to studies in rats, a negative effect on the pregnant woman’s body and her fetuses was not detected, but at the same time, in some experimental individuals, the penetration of the active component through the placenta to the fetus was noted. Since there was no direct study on women during pregnancy and lactation, taking the drug is undesirable. During the bearing of the fetus, if the risk from the disease is greater than from taking the drug, therapy is allowed.
Childhood
According to the instructions in each package of the drug, "Noflux" is forbidden to take at any dosage for children under 12 years old. At a dosage of 10 mg, the boundary age is determined by 18 years. These contraindications are due to the fact that studies on young patients have not been conducted.
Disorders from the excretory system
In case of liver or kidney failure in the initial stages of development, there are no restrictions on taking and adjusting doses, but in case of detection of acute stages of the disease, Noflux should be used with caution.
Drug storage
Keep the Noflux analogues exactly as the original - only in a place protected from light and children and at an air temperature of no higher than 25 degrees. The shelf life of the drug from the date of production is 3 years.
Cost
The price of tablets depends on their quantity in the package and dosage. Due to the margin of pharmacies, it can fluctuate within 100 rubles. You can buy a small package of Noflux in a dosage of 10 mg within 500 rubles. There are 14 tablets in it. A package with twice the number of tablets will cost about 800-1100 rubles.
A doubled dosage of the drug also provides for a corresponding increase in cost, so you can buy 14 tablets of 20 mg for no less than 800 rubles, and a large package - no less than 1500.
Reviews about the tool
There are not too many reviews about taking this remedy on the Internet, since not everyone has the opportunity to regularly take expensive drugs, and the courses of treatment sometimes last up to 1 year. Nevertheless, from those few people who have tested the effect of the drug on themselves, a clear positive line can be identified. Most reviews indicate a quick tangible effect upon first use. Exacerbations of peptic ulcers are treated perfectly, symptoms of GERD and NERD go away.
In most cases, side effects during administration are not noted, but some still focus on the manifestation of headaches during therapy, abdominal pain, nausea and vomiting. Moreover, all concomitant with the reception of the symptom are very weakly expressed and are floating in nature.
Interaction with other means
Very often, medicines based on rabeprazole are prescribed in combination with antibacterials. In this combination, no deviations in the effect on the body from antibacterial agents were observed. At the same time, the effects of rabeprazole became more pronounced compared with monotherapy.
Any combination of the drug with other drugs, the absorption of which depends on the level of acidity, should be accompanied by dosage adjustment on an individual basis.
It is not recommended to use "Noflux" simultaneously with atazanavir or other proton pump inhibitors.
In studies, it was noticed that rabeprazole interferes with the production of cyclosporine.
Also, according to the results of testing the effect of the drug on the body, it was revealed that when it is taken together with methotrextate, the half-life of the latter increases. Such an effect in most cases leads to the need to cancel therapy with proton pump inhibitors.
Conclusion
The disadvantage of the drug is only its cost, which is not affordable for most patients, but who otherwise decided to spend such money on their own health are satisfied. Many who have chosen analogues of this drug do not emit the same positive effects, especially when treating with generics based on omeprazole. Although such tools are cheaper, the effect of them is noticeably smaller.
Among the large list of possible side effects, in reality, only the least serious, and with a floating character, are seen. Given that the positive result from treatment is greater, for a while you can come to terms with such inconveniences.
Due to possible problems in the combination of the drug with other agents, it should be taken only after consultation with a qualified specialist.
Try to constantly monitor your health, go to scheduled examinations to doctors, lead a correct lifestyle, and then you will not have any problems.