In the article, we consider the instructions for Sirdalud and the side effects of this medication.
The drug has an effect on the tone of skeletal muscles, showing a moderate analgesic effect. This drug belongs to the group of muscle relaxants. Its active component is tizanidine.
In the instructions for use for Sirdalud, reviews and analogues are not described. They will be given at the end of the article.
Composition and properties of the drug
The active ingredient of the medication in question is a substance called tizanidine in the form of a hydrochloride. Excipients are silicon dioxide along with stearic acid, microcrystalline cellulose and lactose monohydrate. The form of release of this medicine is tablets. So, now we turn to the indications and find out when this remedy should be used for treatment.
Indications
The use of the drug “Sirdalud” is prescribed by doctors in the following cases:
- With the appearance of spasms of skeletal muscles, which are caused by neurological pathologies (degenerative disease of the spinal cord, sclerosis, paralysis, chronic form of myelopathy and so on).
- Against the background of muscle pain syndrome associated with functional and static disease of the spine (with transverse or cervical syndrome).
- Within the postoperative period, immediately after undergoing surgery for a hernia of the intervertebral discs or osteoporosis of the hip joints.
- In the presence of chronic myelopathy, against the background of multiple sclerosis, degenerative diseases of the spinal cord, circulatory disorders.
- In the presence of central paralysis and in other cases, against the background of spasticity.
Why is Sirdalud needed, not everyone knows.
Instructions for use
With skeletal muscle spasms arising from neurological pathologies, the dosage is selected depending on the reaction to the drug and based on the severity of the symptoms. The initial dosage is 2 milligrams three times. After a few days, you can increase the dosage by 6 milligrams. The optimal daily dosage is from 12 to 20 milligrams. A dose above 36 milligrams per day is dangerous for the development of adverse reactions.
The dosage for the elderly is adjusted. Such patients must be strictly under the constant supervision of hospital staff. Most often, the dosage is reduced, as in elderly patients, renal clearance is slowed (that is, the speed of renal excretion of various substances from the blood). A large dosage causes the accumulation of metabolites in the blood along with the development of an overdose, the appearance of adverse reactions and so on.
This is confirmed by the Sirdalud preparation instructions for use and reviews.
Overdose
To date, several cases of Sirdalud overdose are known, including the example where the dosage taken was 400 milligrams. In all cases, recovery occurred without any features. Symptoms were nausea along with vomiting, decreased pressure, dizziness, drowsiness, miosis, anxiety, respiratory failure, and coma.
For the withdrawal of this drug from the body, repeated administration of activated carbon to the patient is recommended. Forced diuresis may accelerate the excretion of Sirdalud. In the future, symptomatic therapy is performed. Next, let's talk about side effects that occur when using this tool.
Side effects of Sirdaluda
When using this medication, patients may experience various adverse reactions, for example:
- The nervous system can often react with drowsiness, weakness, dizziness. Hallucinations are rarely possible along with insomnia and sleep disturbances.
- The cardiac and vascular system very often responds to the administration of this drug by bradycardia and a decrease in pressure. Side effects of Sirdaluda can be very unpleasant.
- The digestive system responds with dry mouth, nausea, digestive upsets, increased liver transaminase activity, and very rarely hepatitis.
- The skeletal and muscle systems rarely respond to muscle weakness.
- Other side effects of Sirdalud are often fatigue.
When taking the drug in small doses, which are recommended for the relief of painful muscle spasms, drowsiness is noted along with fatigue, dizziness, dry mouth, a slight decrease in pressure, nausea, digestive upsets, and an increase in liver transaminase activity. The previously described side effects of Sirdalud, according to reviews, are manifested in moderately pronounced forms.
As part of taking this drug at a higher dosage, recommended for the treatment of spasticity, absolutely all of the above side effects occur much more often and they are more pronounced, although they are very rarely extremely severe so that treatment has to be interrupted. In addition, patients may experience manifestations in the form of low blood pressure, bradycardia, muscle weakness, insomnia, sleep disturbances, hallucinations, hepatitis, and so on.
Many people want to find an analogue of Sirdalud without side effects.
Contraindications
Contraindications to the use of this drug, as a rule, include:
- The presence of severe violations of the liver.
- Concomitant use of the drug with Fluvoxamine.
- The presence of hypersensitivity to tizanidine or to any other ingredient of the drug.
Since controlled studies of the use of tizanidine in pregnant women have not been conducted, this medicine should not be used at all during gestation, except in situations where the potential benefit significantly exceeds the possible risks. The substance tizanidine is excreted in milk in an insignificant amount. But, nevertheless, women who are breastfeeding should not use this drug in any case.
Interactions with other medicines and alcohol
The simultaneous use of tizanidine with fluvoxamine leads to a multiple increase in the first component. The result of combined use may be a clinically pronounced and prolonged decrease in pressure, leading to drowsiness, and, in addition, weakness and inhibited psychomotor reaction. Caution must be exercised within the framework of the simultaneous administration of tizanidine with other antiarrhythmic drugs (we are talking about Amiodarone, Mexiletine, Propafenone, Enoxacin, Pefloxacin, Ciprofloxacin and Norfloxacin).
The simultaneous administration of the Sirdalud drug with antihypertensive agents, including diuretic drugs, can sometimes provoke a decrease in pressure and bradycardia. Alcohol along with sedatives can enhance the sedative effects of Sirdaluda. According to clinical data, the simultaneous use of oral contraceptives with tizanidine leads to a significant decrease in the clearance of tizanidine.
Pharmacological effects of the drug
This drug is a central muscle relaxant. The main point of its effect is in the human spinal cord. By stimulating the presynaptic receptor, tizanidine inhibits the release of the excitatory amino acid and stimulates receptors that are sensitive to methyl and aspartate. Against the background of all this, suppression of polysynaptic transmission of excitation is achieved at the level of intermediate neurons of the brain. Given that it is this mechanism that is responsible for excess muscle tone, if it is suppressed, it is significantly reduced. In addition to the muscle relaxant property, tizanidine can also produce a central moderate analgesic effect when using Sirdaluda.
The drug is very effective in the presence of acute painful muscle spasm, in the event of chronic spasticity of cerebral and spinal genesis. This means reduces spasticity along with clonic convulsions, as a result of which the resistance to passive movement decreases and the volume of active reactions increases significantly.
What is the justification for the use of Sirdalud?
The main active ingredient of these tablets is tizanidine. It contributes to the processes of muscle relaxation of the spinal cord. It is worth noting what this tool does without any tangible consequences for the human nervous system. Thus, thanks to this medicine, relaxation of skeletal smooth muscles can be achieved by eliminating cramps and cramping. The following medical appointments for the use of this drug are distinguished:
- Recovery during periods following surgery related to the removal of an intervertebral hernia.
- The recovery period immediately after an injury to the spine and certain joints.
- The presence of various diseases of the musculoskeletal system.
- The presence of a stroke along with circulatory disorders in the spinal cord and brain.
- With seizures of limbs and convulsions.
Thus, the indications for use in the Sirdalud medical preparation are quite broad. It is worth noting that this tool has an effect on the functioning of the nervous system. But in those cases when the fastest effect of using the Sirdalud medical product is needed, it is best to use not tablets, but a suspension form for intramuscular or intravenous administration.
Storage conditions
The drug in question must be stored exclusively in an inaccessible place for young children at a temperature that should not exceed twenty degrees. The shelf life of the drug is five years.
We will not consider the instructions for the Sirdalud analogues in detail.
Analogs
Substitutes for the described medication include medicines called “Tizanidine” along with “Tizanil” and “Tizalud”.
Also, the substitute may be "Midokalm". The drug is prescribed for spasticity, hypertonicity of the transverse muscles caused by organic diseases of the central nervous system (with multiple sclerosis, damage to the pyramidal tract, cerebrovascular stroke, encephalomyelitis, myelopathy, etc.). Also, the medication is prescribed for muscle hypertension, spasms caused by diseases of the musculoskeletal system (lumbar or cervical syndrome, with spondylosis, spondylarthrosis, arthrosis of large joints). In addition, this drug is used for rehabilitation after operations in traumatology and orthopedics.
Next, we will go on to discuss the reviews and find out what the patients who happened to take Sirdalud think about and write about this drug.
Sirdalud Reviews and Side Effects
The reviews report that neuropathologists quite often prescribe this medicine to patients. People write that in the process of treatment this drug helps well, but sometimes it takes to drink it for a long time, almost two months.
Take it very often with osteochondrosis. People who have taken the Sirdaluda course for this disease also recommend taking this medicine in their comments, as it helps to achieve the necessary relief. Patients also praise this remedy against the background of circulatory problems. It is noted that in this case, after a course of medication, patients manage to feel better.
What other reviews are there about the use of Sirdalud?
This patient is also praised by those patients who had to go through hernia removal. Such patients are also prescribed Sirdalud to reduce pain and muscle relaxation. Thus, many patients in their reviews often write that this drug is very effective.
People report side effects that often the pressure decreases, the heart rate slows down. Sometimes dry mouth, nausea and drowsiness are felt. All these manifestations are rather unpleasant, but they are not always.
We reviewed the Sirdalud preparation instructions, reviews and analogues.