In the article, we consider the instructions, analogs and reviews for the Sparflo drug.
It is an antibacterial drug with a wide spectrum of action. Under the influence of its active component, inhibition of enzymes occurs, which are responsible for the formation of new bacterial DNA. As a result, the pathogenic microorganism disappears the ability to reproduce, its death occurs. The main advantage of this medication is that it has a pronounced post-therapeutic effect. That is, even after removing the active component from the body, pathogens remain non-viable.
A detailed description of Sparflo and instructions are presented below.
Structure
Each tablet contains 200 mg of sparfloxacin. Additional components are: magnesium stearate, talc, colloidal silicon dioxide, crospovidone, MCC, corn starch.
The tablets are film coated with a yellow quinoline dye, talc, titanium dioxide, propylene glycol and hypromellose.
Pharmacological forms
According to the instructions for Sparflo, the manufacturer produces the medicine in a single pharmacological form - in the form of coated tablets. The tablets are packed in a blister, each of which holds 6 pieces. A cardboard box contains one blister.
Pharmacodynamics and pharmacokinetics
Sparflo has an antibacterial, bactericidal, antimicrobial effect. Sparfloxacin is a derivative of fluoroquinolone, the antimicrobial effect is due to the mechanism of inhibition of bacterial DNA gyrase, despiralizing the chromosome regions of DNA, which reduces the cell's ability to divide. It is important to note that there is no gyrase in the cells of the microorganism; therefore, Sparflo has low toxicity. The active component is also able to influence the lysis of cell walls, resulting in a bactericidal effect against gram-negative microorganisms during their rest.
After the release of the active substance from the plasma, a post-antibiotic effect is maintained for from half an hour to 4 hours.
"Sparflo" is a bactericidal agent that has a wide range of effects, and therefore has activity against anaerobes and cocci (gram-positive) and some gram-negative microorganisms. The activity of the main component is similar to the activity of aminoglycosides. This is confirmed by the instructions for use for "Sparflo".
The absorption level after oral administration reaches 90%, does not depend on the intake of milk or food. The highest concentration when taken after meals is noted 30 minutes later than when taking the drug on an empty stomach.
In all tissues, except for the nervous and rich in fats, sparfloxacin is well distributed. It binds to albumin in the blood by approximately 45%. The maximum saturation after oral use is observed after 3 hours, and the concentration of the active component in the tissues is greater than in the blood, about 2-12 times.
Sparfloxacin is metabolized in the tissues of the liver, about 40% of it is excreted together with feces, about 10% of the unchanged substance comes out with urine. Sparfloxacin is excreted up to 30 hours, and, in the presence of renal failure in the patient, the elimination half-life is somewhat longer. The cumulation of the active component is absent.
This is indicated in the instructions for Sparflo. A photo of the drug is presented above.
Indications for use
Sparflo is often prescribed if the patient is diagnosed with such infectious and inflammatory diseases as:
- Gynecological infections, such as chlamydia and gonorrhea.
- Osteomyelitis and other inflammatory processes localized in the joints and bones.
- Leprosy, infectious dermatitis, furunculosis, pyoderma, abscesses of the skin.
- Infections of the biliary tract, gastrointestinal tract, abdominal cavity.
- Prostatitis, adnexitis and other inflammatory processes localized in the organs of the reproductive system.
- Pyelitis, non-gonococcal urethritis, cystitis, other infectious and inflammatory pathologies of the urinary system.
- Infectious and inflammatory diseases affecting the eyes, middle ear, paranasal sinuses, provoked by gram-negative flora, for example, staphylococci.
- Respiratory diseases such as tuberculosis, pneumonia, obstructive pathologies provoked by staphylococci, streptococci, Klebsiella, mycoplasmas, chlamydia.
In addition, Sparflo is often recommended for infections arising from immunodeficiency, immunosuppressive therapy, and also in the treatment of patients with neutropenia.
Contraindications
In accordance with the instructions for Sparflo, you should not use it if the patient has the following diseases or physiological conditions:
- Lactation period.
- Pregnancy.
- Severe renal failure.
- Glucose-6-phosphate dehydrogenase deficiency.
- Elongation of the QT interval on the ECG, the presence of other risk factors for arrhythmias, such as insufficient heart function in the chronic form, atrial fibrillation, bradycardia, hypokalemia.
- Children's age, the incomplete process of the formation of the skeleton.
- Epilepsy.
- Hyperresponsiveness to any of the main or additional components that are part of Sparflot.
Negative impact
The instructions and reviews for Sparflo confirm that, against the background of using the product, negative effects from various organs and their systems may develop:
- Thrombocytopenia, leukopenia, eosinophilia, anemia, granulocytopenia, thrombocytosis, leukocytosis from the hematopoietic system.
- Lyell's syndrome, Quincke's edema, exudative erythrem (multiform and nodular), petechiae, fever, pruritus as allergic reactions.
- Myalgia, arthralgia, tenosynovitis from the musculoskeletal system.
- Crystalluria, hematuria from the urine excretion system.
- Photosensitivity, hearing loss, visual impairment, such as a change in color perception, tinnitus, diplopia, distortion of taste, smell are manifested by the sensory organs.
- Fainting conditions, hallucinations, depression, confusion, nightmares, increased intracranial pressure, sweating, peripheral paralgesia, tremors, anxiety, drowsiness, increased fatigue, headaches, dizziness from the nervous system.
- Shortness of breath from the respiratory system.
- Liver necrosis, hepatitis, cholestatic jaundice, abdominal pain, loss of appetite, diarrhea, flatulence, indigestion, vomiting, nausea from the gastrointestinal tract.
- Cerebral artery thrombosis, lengthening of the QT interval, tachycardia from the CCC.
Instructions for Sparflot
It is necessary to take tablets inside, regardless of the time of eating. They should be washed down with water in sufficient quantities, avoiding crushing or chewing. The treatment regimens using the drug differ from each other depending on the causative agent and the genesis of the disease, the treatment is aimed at eliminating.
In the treatment of bronchitis in the acute stage, pneumonia should be taken once 400 mg of the drug on the first day, in the next 10 days - 200 mg.
With sinusitis and other infections of the ENT organs, a single initial dose of 400 mg is indicated (on the first day), then the therapy should be continued for another 10 days, taking 200 mg once.
Combined therapy for pulmonary tuberculosis should be carried out using other anti-TB drugs. In this case, it is necessary to take 400 mg once on the first day, and 200 mg on the next 90 days.
For the treatment of infectious pathologies affecting the urinary tract, a single dose of Sparflo 200 mg is indicated on the first day, and 100 mg on the next 14 days.
For the treatment of purulent urethritis, a single dose of 400 mg is indicated on the first day, then 200 mg every 24 hours for 6 days.
If therapy for non-gonococcal urethritis is required, 400 mg is indicated once, then therapy should be continued, taking 100 mg over the next 6 days.
In order to treat chlamydial infections, bacterial prostatitis, 400 mg should be taken once, and then, over the next two weeks, 200 mg should be used.
For infectious lesions of the skin, the initial single dose is 400 mg, and then for 7 days - 200 mg.
For the purpose of leprosy therapy, it is necessary to take 200 mg per 90 days. The instructions for Sparflo tablets are very detailed.
Overdose
If the recommended dosages are not observed, exacerbation of side effects is possible. Currently, a specific antidote to medicine is not known. In this regard, if an overdose occurs, the patient is shown symptomatic therapy. If necessary, hemodialysis or peritoneal dialysis is recommended.
Interaction with other drugs
What else does the instruction manual for Sparflot tell us?
With concurrent administration with certain medications, a diverse interaction of the active component may be noted.
So, when taken with NSAIDs (except acetylsalicylic acid), the risk of seizures increases. When used concomitantly with iron preparations, for example, sucralfates and antacids, the absorption of sparfloxacin decreases.
When used with metoclopramide, the absorption rate of sporfloxacin increases, and the time to reach its highest concentration decreases.
When used with other antimicrobial agents such as clindamycin, metronidazole, aminoglycosides, beta-lactams, synergism is noted.
The concomitant use of cyclosporine causes an increase in serum creatinine. This makes it necessary to constantly monitor this indicator at least twice a week.
Cost
The average cost of a medication is at the level of 340 rubles per package, containing 6 tablets. It depends on the region and the pharmacy network.
The instructions for Sparflo do not provide analogues.
Analogs
The analogues of the drug, with sparfloxacin in the composition, are:
A doctor should select a replacement.
Reviews
Reviews about the use of Sparflo are quite common. As positive characteristics of the drug, patients note its effectiveness, speed, ease of use. Among the negative qualities, the high toxicity of the drug, the presence of an extensive list of negative effects are often noted.
It is important to remember that Sparflo is an antibiotic, therefore, the appointment of therapy with its use should be carried out by the attending physician.