"Mexibel" from "Belmedpreparatov" is a medication that has antihypoxant, antioxidant, nootropic, anticonvulsant, membrane-protective, anxiolytic effects.
Forms of release and specifics of composition
The drug has two forms of release.
1) Coated tablets.
Each Mexibela tablet from Belmedpreparatov contains an active substance: methylethylpyridinol succinate (one hundred twenty-five milligrams). Excipients are the following: methyl cellulose, calcium stearate, lactose monohydrate, silicon colloidal anhydrous dioxide, povidone K-25, opadra II color (lot 85F), white, potato starch, croscarmellose sodium.
2) Injection solution in a five percent concentration, which contains 0.2 grams of Mexidol as an active substance. Reviews about "Mexibel" from "Belmedpreparatov" are presented below.
Pharmacological properties
The drug increases the patient’s resistance to stress and the influence of the main damaging symptoms, as well as to oxygen-related pathological conditions (hypoxia, intoxication with antipsychotic drugs and alcohol, shock, ischemia, cerebral circulation defects, etc.). It has a hypolipidemic effect of a moderate degree.
Thanks to the use of the drug, the state of the membrane structures of blood cells is stabilized, leukocytes and platelets become more stable during hemolysis, the physicochemical changes in the properties of the membranes of the nervous tissue cells caused by hypoxia are eliminated (the viscosity of the lipid bilayer decreases, the membrane fluidity increases and the proportion of lipid-protein increases), and this , in turn, has a beneficial effect on biosynthetic and metabolic activity.
Lipid peroxidation is inhibited, the activity of superoxide dismutase increases, the content of cGMP and cAMP inside the cell increases, the activity of membrane-bound enzymes is modulated (acetylcholinesterase, adenylate cyclase, Ca-independent phosphodiesterase), receptor complexes (acetylcholine, GABA, their benzazep binding to receptors and improving the transport of neurotransmitters, as well as synaptic transmission). According to reviews, instructions for "Mexibel" "Belmedpreparatov" are available in each pack.
Thanks to the use of the drug, the content of dopamine in the brain increases, compensatory activation of aerobic glycolysis increases, redox processes in mitochondria are restored under conditions of hypoxia, and the synthesis of creatinine phosphate and ATP increases. Enzyme toxemia and endogenous intoxication with acute pancreatitis are reduced.
Efficiency
Injections by Mexibelom (Belmedpreparaty) improve the performance and memory of patients, have an anxiolytic effect, eliminate tension, anxiety, anxiety, fear, and improve the emotional background. In addition, the drug has a neuroprotective effect, stimulates regenerative and adaptive processes in the brain in the presence of a traumatic brain injury.
It accelerates the evolution of hemorrhages occurring inside the brain, including also post-traumatic ones. In patients who have suffered a serious cerebrovascular defect, as part of a comprehensive treatment, it favorably affects oxygen transfer processes in the brain during hypoxia, reducing the maximum respiratory rate and increasing the stationary level of oxygen partial pressure in the nervous tissue. It also reduces the effects determined by reperfusion syndrome during coronary insufficiency.
Reviews about "Mexibel" ("Belmedpreparaty") are of interest to many.
When is the drug used?
The tool is used as an integral part of complex therapy for:
- circulatory disorders of the brain of an acute nature, determined by traumatic brain injury;
- cognitive impairment in atherosclerotic lesions of the vessels of the brain of the head;
- intellectual insufficiency and memory impairment in elderly patients;
- intoxication;
- withdrawal symptoms on the background of alcoholism, if there are vegetovascular and neurosis-like defects;
- anxiety disorders in neurosis and neurotic conditions;
- acute inflammatory processes occurring in the abdominal cavity (peritonitis, acute necrotic pancreatitis);
- acute poisoning with antipsychotic drugs. According to reviews, injections "Mexibel" ("Belmedpreparaty") are very effective.
Dosage
The drug in the form of tablets is taken orally from 0.25 to 0.5 grams per day in two or three doses. In this case, the maximum dose ranges from 0.6 to 0.8 grams. The duration of therapy is from two to six weeks. In order to suppress alcohol withdrawal, from five to seven days. Each patient is individually selected dosage of the drug, which is determined by the degree of the disease. Gradually, the treatment stops, the dose decreases over two to three days.
In the form of a solution, the drug is injected into a vein, drip, from forty to sixty drops per minute. Dosage is also selected individually. Five to ten milligrams per kilogram are recommended per day. The maximum daily norm is 800 mg. This points to the Mexibel tablets (Belmedpreparaty) instructions.
special instructions
In the treatment of acute cerebral blood circulation, the drug is used as part of a comprehensive treatment of drip-intravenously two hundred to three milligrams once a day for five to seven days, after which the transition to intramuscular use of the drug in the form of an injection of two hundred milligrams twice a day is carried out. The maximum dose can be increased to five hundred milligrams, if the course of the disease is more severe. Treatment lasts from ten to fourteen days.
With dyscirculatory encephalopathy, which is in a state of decompensation, an intravenous drip of one hundred to two hundred milligrams should be prescribed two to three times a day for two weeks, and after that, the introduction of two hundred milligrams of muscle into the muscle during the same period.
With alcohol withdrawal syndrome, a drip intravenous administration of the drug is carried out, two hundred three milligrams from five to seven days.
Intoxication with acute antipsychotic drugs involves intravenous administration, from one hundred to three hundred milligrams in one to two weeks.
With purulent-inflammatory processes proceeding in an acute form in the abdominal cavity, the dosage is determined by the severity of the pathology, the course options, and the prevalence of the processes. Cancellation is carried out gradually, only after achieving a stable clinical and laboratory effect of a positive nature.
With interstitial edematous pancreatitis in acute form, one hundred milligrams is prescribed three times a day drip.
With a mild course of necrotic pancreatitis, one hundred to two hundred milligrams is administered intravenously three times a day: for an average degree, two hundred milligrams; if it is heavy, eight hundred milligrams is used in a pulse dose in the first day, divided into two doses, then three hundred milligrams twice a day, gradually the daily dose decreases. If the course of the disease is very severe, then the initial dose is eight hundred milligrams per day until the symptoms of pancreatogenic shock are permanently blocked, as soon as the condition stabilizes, three to four hundred milligrams are administered intravenously twice a day, the daily dose is gradually reduced. Cancellation also should not be abrupt; it is carried out after a steady improvement in indicators.
Side symptoms
According to reviews, the digestive system can respond to Mexibel (Belmedpreparaty) as follows: “metallic” aftertaste, dryness, flatulence, nausea and diarrhea. Among other side effects, the state of heat spreading through the body, drowsiness, allergic reactions are noted.
Contraindications
Individual sensitivity to the drug. Acute hepatic and / or renal failure, age up to eighteen years, pregnancy, lactation. The drug is used with caution if there is a history of hypersensitivity reactions.
Reviews about "Mexibel" ("Belmedpreparaty")
Reviews of patients about the use of the drug are controversial. Among its advantages, efficiency and affordable price are noted. The drug quickly helps, eliminates severe headaches. However, injections are quite painful, so they need to be administered gradually to reduce discomfort. At the same time, it is noted that there is a high risk of side effects, such as chills, muscle weakness, and a sharp increase in pressure. Therefore, the drug should be used only after medical advice.