Modern people very often experience neurosis, irritability and stress. Against the background of such conditions, a person's general health and overall health noticeably worsen. The consequences of neurosis are insomnia, fatigue, lethargy, high blood pressure, tachycardia, cramping and more. Therefore, with severe stress and irritability, it is very important to take a drug in time that helps calm a person.
The most popular remedy with such properties is the medicine “Corvalcaps”. Instructions for use, the form, cost and characteristics of the drug are discussed below.
Release form, composition, description, packaging
The drug “Corvalcaps”, reviews of which are described below, goes on sale in the form of soft capsules. They are placed in blisters and cardboard packaging.
The composition of this medicine includes such basic components as phenobarbital and ethyl alpha bromisovalerianic acid ester. Also, the medication in question contains peppermint oil, trihydrate, sodium acetate, purified water and polyethylene glycol 200 (excipients).
As for the shell of the drug, it consists of glycerol, gelatin, propyl parahydroxybenzoate and methyl parahydroxybenzoate.
Basic properties
What antispasmodic drugs are known to you? “Corvalcaps” is the most effective medication that acts not only antispasmodically, but also soothingly.
The effectiveness of this tool is determined by the properties of the components that make up its composition.
Ethyl alpha-bromisovalerianic acid ester exhibits reflex sedative and antispasmodic properties. Such features of the medication are caused by irritation of the receptors of the nasopharynx and oral cavity, as well as a decrease in the excitability (reflex) in the central nervous system, an increase in the inhibition processes in the subcortical structures and neurons of the cerebral cortex, a decrease in the activity of vasomotor centers and local antispasmodic effect on the smooth muscles of the vessels.
As for an ingredient such as phenobarbital, it helps to suppress the activating effect of the centers of the reticular formation of the medulla oblongata and midbrain on the cerebral cortex. As a result of this, exciting flows that affect the subcortical structures and the cerebral cortex are reduced.
According to experts, it is precisely such properties of the drug (depending on its dosage) that cause a hypnotic or sedative effect.
What other properties are inherent in the medicine “Corvalcaps”, the price of which is listed below? This drug reduces total blood pressure, reduces the stimulating effect on peripheral and coronary vessels, vasomotor centers, and also relieves and prevents spasms of blood vessels, including cardiac ones.
Kinetic indicators
Where are Corvalcaps capsules (tablets) absorbed? When administered, this drug begins to be absorbed already in the sublingual region. Its bioavailability is very high and amounts to approximately 60-80%.
The effect of the drug develops much faster (after about 5-12 minutes) when it is held in the oral cavity (sublingual absorption), that is, after a capsule has been bitten.
When the drug is swallowed in its entirety, its effect is noted after 20-45 minutes and lasts for 3-6 hours.
In patients who have previously taken barbituric acid, the effectiveness of the drug is reduced. This happens due to the accelerated metabolism of phenobarbital in the liver (it is in this organ that barbiturates cause the induction of enzymes).
In elderly people and patients with liver cirrhosis, the metabolism of the drug in question is reduced, therefore, in this category of people, the half-life of the drug is lengthened. This requires a reduction in dosages and an increase in the interval between capsule doses.
Indications
Preparations containing phenobarbital and ethyl ethyl bromisovalerianic acid ester (for example, Corvalcaps) are used for:
- neurosis with increased irritability;
- vegetative-vascular dystonia and hypertension (in complex therapy);
- insomnia;
- mild spasms of coronary vessels and tachycardia;
- intestinal cramps due to neurovegetative disorders (as an antispasmodic).
Contraindications
Drugs containing ethyl alpha-bromisovalerianic acid ester and phenobarbital (including Corvalcaps) are not recommended for:
- expressed violations in the work of the kidneys or liver, liver porphyria;
- hypersensitivity to bromine and drug components;
- severe heart failure.
The drug "Corvalcaps": instructions for use
In what dosages is this drug prescribed for patients? You will find out about it right now.
Soft capsules "Corvalcaps" are taken only inside. The use of this tool does not depend on the meal time.
The medication is prescribed one capsule three times a day, washed down with plain water. If required (for example, with severe tachycardia or spasms of the coronary vessels), then a single dosage of the drug can be increased to two capsules.
How long should I take Corvalcaps? The instruction for use states that the duration of treatment with this drug is determined by the doctor (depends on the tolerance of the drug and the clinical effect).
Overdose cases
What happens if you take antispasmodic drugs in high doses? Such patient behavior can contribute to the development of addiction, withdrawal symptoms and psychomotor agitation.
We can not say that the abrupt cessation of medication causes withdrawal symptoms.
Signs of an overdose of Corvalcaps are confusion, CNS depression, dizziness, drowsiness, and ataxia. In severe poisoning, the patient may experience respiratory failure, arrhythmia, tachycardia, coma, collapse, and lower blood pressure.
To eliminate such conditions, symptomatic treatment is used.
Side effects
The drug “Corvalcaps Extra” is well tolerated by patients. In some cases, the medication in question can cause side effects such as:
- drowsiness, allergic reactions;
- slight dizziness, discomfort in the abdomen;
- decreased concentration, nausea;
- slow heart rate.
These reactions are eliminated by reducing the dosage of the drug.
With prolonged use of the drug, the patient may become dependent on the drug and the phenomenon of bromism. The following symptoms also develop: depression, central nervous system depression, acne, apathy, hemorrhagic diathesis, rhinitis, confusion, conjunctivitis, impaired coordination.
Interaction with other means
Can I use Corvalcaps capsules with other drugs? The instruction for use claims that the action of the drug in question is enhanced by medications of a central depressing type.
Phenobarbital, which is part of the drug, can easily induce liver enzymes. In this regard, it is undesirable to combine it with drugs that are metabolized in the liver (i.e., griseofulvin, coumarin derivatives, oral contraceptives, glucocorticoids), since their effectiveness will be reduced due to the high level of metabolism.
Capsules "Corvalcaps" enhance the effect of sleeping pills, painkillers and local anesthetics (due to the content of barbituric acid derivatives).
With the combination of the drug with valproic acid , its effect is enhanced.
Concurrent administration of a medication with methotrexate increases the toxicity of the latter.
Alcoholic beverages enhance the effect of Corvalcaps, as well as increase its toxicity.
Special information
Capsules "Korvalkaps" produces Kiev Vitamin Plant.
When treating with this remedy, the use of alcoholic beverages should be avoided.
It is forbidden to use the drug for a long time in connection with the possible development of dependence on it.
With extreme caution, this medicine is prescribed for arterial hypotension.
The medication in question contains phenobarbital. This component can cause disturbances in the speed of a person's psychomotor reactions and its coordination. Therefore, taking capsules for people who work with dangerous mechanisms (drivers of vehicles) should be very careful.
There is no experience with the use of the drug in childhood.
Cost and reviews
How much do Corvalcaps capsules (Kiev Vitamin Plant) cost? The price of this medicine is about 80-120 rubles.
Customer reviews report that the drug in question is very effective in treating neurosis and irritability. In addition, taking this remedy relieves spasms of blood vessels and intestines.
Also, the advantages of the drug in question include its low cost and availability in all pharmacies.