Instructions for use give the drug "Gentamicin" ointment, the definition is this: this drug is a typical representative of the antibiotics of the aminoglycoside group with a wide spectrum of action.
The drug is available in tubes and cans of fifteen grams with a concentration of the active substance in one tenth of a percent.
The drug "Gentamicin" instruction: pharmacological properties
The effect it has is bactericidal. It is active against gram-negative aerobic bacteria, gram-positive cocci aerobes, anaerobic bacteria, as well as niserella and some of the streptococcus strains are immune to it.
The medicine "Gentamicin" (ointment). Instructions for use: pharmacokinetics
After intramuscular injection, the active substance is rapidly absorbed and reaches a maximum concentration in the blood in half an hour to an hour. Only about ten percent of the drug binds to plasma proteins. It is evenly distributed in all body tissues, is not metabolized, is able to penetrate the placental barrier. The half-life of the drug ranges from two to four hours, up to ninety-five percent of the substance is excreted in the urine, the rest with bile.
The drug "Gentamicin." Instruction: method of application
For external use, it is used three to four times a day. The maximum allowable daily dose for adults, as well as for children, is described only with intramuscular and intravenous administration and amounts to five milligrams per kilogram of body weight.
Gentamicin ointment. Instructions: interaction with other medicinal substances
In the case of simultaneous use with vancomycin, aminoglycosides, cephalosporins, ethacrine acid, an increase in the toxic effect on the hearing organs and kidneys is likely. And the use together with indomethacin, furosemide, ethacrylic acid leads to an increase in the concentration of gentamicin in the blood and an increase in its toxic effect on the body. If you use it simultaneously with opioid analgesics and substances that are used to achieve inhalation anesthesia, then the risk of neuromuscular blockade increases, up to the occurrence of apnea.
"Gentamicin" instruction: use for lactation and pregnancy
This drug is absolutely contraindicated in pregnancy. If there is a need for its use in the lactation period, breastfeeding should be stopped immediately.
Side effects of the ointment "Gentamicin" instructions for its use describe the following:
- From the gastrointestinal tract, vomiting, nausea, hyperbilirubinemia can develop, and activity of hepatic transaminases may increase.
- From the hemopoietic organs, anemia, granulocytopenia, leukopenia, thrombocytopenia can develop.
- The urinary system can also suffer through the development of proteinuria, oliguria, renal failure, and microhematuria.
- The central nervous system and peripheral nervous system can give headaches, hearing loss, disorders of the vestibular apparatus, irreversible deafness, impaired neuromuscular conduction, drowsiness.
- Allergic reactions, such as itching, skin rash, fever, urticaria, and the rarest of them, Quincke's edema, sometimes also develop.
Indications for use of ointment "Gentamicin"
For external use against infectious and inflammatory pathologies that are caused by microorganisms sensitive to this drug, such as superficial folliculitis, pyoderma (even gangrenous), sycosis, furunculosis, seborrheic infected dermatitis, paronychia, acne infected, varicose infections, secondary bacterial infections and fungal infections of the skin, infected skin wounds of various etiologies (wounds, burns, ulcers that are difficult to heal, insect bites).