What is the drug "Vilprafen 1000"? You will find the answer to this difficult medical question in the materials of this article. Also from it you will learn about how to take this medication, what it is intended for, whether it has adverse reactions and contraindications, how it can be replaced, and so on.
Composition, packaging and release form of a medical product
The drug "Vilprafen 1000" can be purchased at the pharmacy in the form of dispersible white tablets (they can also be with a yellowish tint). They have an oblong shape with a notch and the inscription "IOSA" on one side, with the number "1000" on the other. It should also be noted that this product has a sweetish flavor and strawberry flavor.
The active substance of the drug "Vilprafen 1000" is josamycin. As for the auxiliary components, they include aspartame, hyprolose, colloidal silicon dioxide, microcrystalline cellulose, docusate sodium, strawberry flavoring and magnesium stearate.
On sale, the drug comes in blisters of 5 tablets, placed in a cardboard box.
Pharmacological action of the drug
What is the medicine "Vilprafen 1000"? Instructions for use of this medication contain information that this remedy is an antibiotic belonging to the macrolide group.
The mechanism of action of the medication in question is associated with a violation of protein synthesis in microbial cells. This effect is due to the reversible binding of the active substance to the 50S subunit of the ribosome.
In therapeutic volumes, this agent is able to exert a bacteriostatic effect, slowing the reproduction and growth of bacteria. If you create high concentrations in the focus of inflammation, then a bactericidal effect is possible.
The drug "Vilprafen 1000" is particularly active against gram-positive and gram-negative microorganisms. However, it does not affect enterobacteria. In this regard, this drug can not adversely affect the state of the gastrointestinal microflora.
In some cases, the medication remains active with resistance to erythromycin, as well as other macrolides.
Pharmacokinetics of the drug
How long is Vilprafen 1000 absorbed? The instruction of this tool states that after ingestion, the active element of the drug is absorbed quite quickly from the digestive tract. At the same time, eating does not affect its bioavailability.
The highest concentration of the drug is achieved approximately an hour after ingestion. At a dosage of 1 g, the maximum concentration is about 2-3 μg / ml.
The active substance of the drug is fairly well distributed throughout the tissues and internal organs (with the exception of the brain). In this case, the medication creates concentrations that exceed plasma and remain at the therapeutic level for quite a long time.
High concentrations of josamycin are found in the tonsils, lungs, saliva, lacrimal fluid and sweat. The medicine easily passes through the placental barrier, and is also secreted in breast milk.
Josamycin (the active substance of the drug) is metabolized in the liver. In this case, active metabolites are formed.
The drug is excreted mainly with bile. But excretion with urine does not exceed 10%.
Indications for the use of a medical device
In what cases should the drug "Vilprafen 1000" be used? We will consider reviews about this medication a bit later. Now I want to tell you that this medicine is prescribed only for infectious and inflammatory diseases that were caused by microorganisms sensitive to the drug:
- diphtheria (as an adjunct to diphtheria antitoxin therapy);
- infections of the ENT organs and upper respiratory tract (laryngitis, pharyngitis, otitis media, tonsillitis, sinusitis and paratonsillitis);
- lower respiratory tract infections (exacerbation of chronic bronchitis, acute bronchitis, community-acquired pneumonia);
- whooping cough;
- scarlet fever (if there is hypersensitivity to penicillin);
- infections of the oral cavity (pericoronitis, gingivitis, alveolitis, periodontitis, alveolar abscess);
- psittacosis;
- infections of soft tissues and skin (furuncle, folliculitis, acne, furunculosis, lymphangitis, abscess, phlegmon, lymphadenitis, panaritium, wound, burn and postoperative infections);
- eye infections (dacryocystitis and blepharitis);
- erysipelas (if there is hypersensitivity to penicillin);
- anthrax;
- infections of the genital organs and urinary tract (cervicitis, urethritis, prostatitis, epididymitis);
- venereal lymphogranuloma ;
- digestive diseases that are associated with Helicobacter pylori;
- syphilis and gonorrhea (if there is hypersensitivity to penicillin).
Contraindications to the use of the medication
In what cases is it impossible to use the drug "Vilprafen Solutab 1000"? Reviews of experts say that this medication has the following contraindications:
- children with low body weight (less than 10 kg);
- severe violations of the liver;
- hypersensitivity to the active substance;
- hypersensitivity to antibiotic drugs belonging to the macrolide group.
The drug "Vilprafen 1000": instructions for use of the drug
The dosage of this drug should be determined only by the attending physician and only individually.
For adults and adolescents over 14 years, the usual amount of this tool is 1-2 g. It is recommended to take it in 2-3 doses. If necessary, the dose can be increased (for example, up to 3 g per day).
The daily dose for children whose body weight is at least 10 kg is prescribed based on the calculation of 40-50 mg per kg of weight. The medication should be taken 2-3 times a day.
Based on the foregoing, it is easy to calculate that a child with a body weight of 10-20 kg should be given 250-500 mg of the drug twice a day (a quarter or half of a tablet previously dissolved in water).
A child weighing 20-40 kg is given 500-1000 mg twice a day (half or a whole tablet dissolved in water).
Children weighing more than 40 kg are prescribed 1000 mg (that is, one tablet) twice a day.
How much should you take the drug "Vilprafen" (1000 mg)? The duration of treatment with this drug is determined only by the doctor (usually it is 5-21 days, depending on the severity and nature of the infection).
Scheme of anti-Helicobacter therapy (treatment of gastric ulcer)
Now you know how to take Vilprafen Solutab 1000. If you need anti-Helicobacter therapy, then this medication is prescribed in a volume of 1 g twice a day for 1-2 weeks. In this case, the drug should be combined with other agents in their standard doses (“Famotidine”, “Omeprazole”, “Omez”, “Omez D”, etc.).
Dispersible medicine can be taken orally in various ways. The tablets are swallowed whole (washed down with water) or previously dissolved in 20 ml of water. In the latter case, before taking it is necessary to mix the resulting suspension well.
Side effects after using the medication
Analogs of Vilprafen 1000, as well as the drug in question itself, can cause a number of undesirable reactions. Among the side effects, the following are most often observed:
- Alimentary tract: stomach discomfort, stomach discomfort, nausea, diarrhea, stomatitis, vomiting, constipation, pseudomembranous colitis and decreased appetite.
- Allergy : urticaria, anaphylactoid reaction, erythema multiforme exudative, Quincke's edema, bullous dermatitis, Stevens-Johnson syndrome).
- Bile ducts and liver: jaundice, hepatic dysfunction.
- Sensory organs: dose-dependent transient hearing impairment.
- Others : purple.
Interaction with other medical devices
Since bacteriostatic antibiotics can lower the antimicrobial effect of bactericidal antibiotics, their combined use should be avoided.
Josamycin is strictly forbidden to appoint along with lincosamides. This is due to the fact that a mutual decrease in their effectiveness is possible.
Representatives of the macrolide group noticeably slow down the elimination of xanthines. This can lead to symptoms of intoxication.
With the joint use of josamycin and antihistamines containing astemizole or terfenadine, the risk of developing life-threatening arrhythmias may increase.
There are reports of increased vasoconstriction as a result of the joint use of antibiotics from the group of macrolides and ergot alkaloids.
The combined use of cyclosporine and josamycin causes an increase in the level of cyclosporin in the blood, and also increases the risk of nephrotoxicity.
With the combined use of digoxin and josamycin, an increase in the level of the first in the blood is possible.
Special instructions for the use of the drug "Vilprafen 1000"
In case of severe and persistent diarrhea, it is necessary to bear in mind the likelihood of developing life-threatening pseudomembranous colitis (while taking josamycin).
In patients with renal failure, therapy is recommended taking into account the results of laboratory tests.
The likelihood of cross-resistance to various antibiotic agents belonging to the macrolide group must be taken into account (bacteria resistant to treatment with antibiotics related in chemical structure may be resistant to josamycin).
Cost and analogues of the drug
The price of the drug in question is not very high. So, for 10 tablets of the drug you will have to give about 150 Russian rubles. Agree, this is a fairly low cost, given the effectiveness of the drug "Vilprafen 1000". Analogs cheaper you are unlikely to find in pharmacies.
If the medication in question is contraindicated for you, then it can be replaced with one of the following medicines: Midecamycin, Roxithromycin, Spiramycin, Clarithromycin, Azithromycin or Erythromycin. These drugs are similar in active substance. This medication has no so-called structural analogues.
Reviews of patients and specialists about the medical device
Today there are a fairly large number of positive reviews about this medication. Patients who have ever taken this drug notice its quick healing effect, which is noticeable after taking the first dosages. This is especially observed with abnormalities such as angina, otitis media, sinusitis and cystitis.
Side effects after taking the drug are quite rare. The authors of some reviews say about the disorder of the stool, as well as periodic nausea. By the way, these unpleasant effects spontaneously disappear after a few days.
It should also be noted that a large number of patients are pleased with the price of this drug.
In the reviews of specialists, the possibility of treatment with Vilprafen during pregnancy is noted.