In the article, we consider the instructions for use for the drug "Bicillin-5" for adults.
It is an antimicrobial drug with a complex effect, which has a small spectrum of antibacterial effects, which refers to penicillins. Means of this group are popular due to their plant origin, as some types of mold produce them. One of the most stable natural penicillins is benzylpenicillin.
Application features
A drug is used to treat infectious pathologies, the causative agents of which are highly sensitive to such a component as benzylpenicillin. The drug "Bicillin-5" with regular use can prevent rheumatism in both children and adults. The pharmacological effect of the drug is based on the provision of a bactericidal effect by inhibiting the synthesis of mucopeptides of the cell membranes of microelements. The use of the drug is characterized by a prolonged effect, since the therapeutic effect persists for four weeks from the time of intramuscular administration of the drug.
The drug is excreted mainly by the kidneys, in small quantities - with saliva, sweat and sputum.
Release Forms
According to the instructions, "Bicillin-5" is made in the form of a powder for the manufacture of a suspension used intramuscularly by injection. The composition of the medicine includes only two components, namely 1200000 IU of benzathine benzylpenicillin and 300000 IU of benzylpenicillin novocaine salt. "Bitsillin-5" is available in packs with one, five, ten and fifty bottles. To prevent damage to the product, you must provide the necessary storage conditions. In accordance with the recommendations, it should be stored at a temperature of 15 to 25 degrees, preferring dry places protected from ultraviolet radiation.
Structure
As the instructions indicate, "Bicillin-5" is made in the form of a powder for the preparation of an injection solution that is administered intramuscularly. The drug has a bitter taste and a milky tint. It is dispensed in vials in an amount of ten milliliters. The drug is produced in Russia.
The composition for the manufacture of the solution includes: 1200 units of benzathine benzylpenicillin; 300,000 units of novocaine salt of benzylpenicillin.
The drug is among the antibiotics of a number of penicillins, is produced naturally and dispensed only by prescription.
Indications
In accordance with the instructions for "Bicillin-5", the main indications for prescribing the drug are as follows:
- infections caused by pathological microorganisms with the desired degree of sensitivity (for example, syphilis and other similar diseases);
- diseases in which pathogens are pale treponemas;
- streptococcal infections, among which acute tonsillitis, wound infections, scarlet fever, rheumatism and erysipelas, are especially common.
It must be said that the drug is not active against all streptococci. The only exception is streptococcus from group B.
Contraindications
What else does the instruction for use with Bicillin-5 injections tell us? The drug cannot be prescribed to people with hypersensitivity to its active substances and individual intolerance to a number of elements, for example, beta-lactam antibiotics, penicillin, procaine; with impaired renal activity; pseudomembranous type of colitis; allergic reactions, hay fever and bronchial asthma. Treatment with a drug during pregnancy and breastfeeding is not excluded, however, in this situation, the recommendations of the drug manufacturers and doctors regarding the establishment of the optimal daily amount must be followed. When carrying a baby, the use of a medication in the first trimester is strictly limited; during breastfeeding, a temporary cessation of lactation may be necessary.
Drug dosage
According to the official instructions, "Bitsillin-5" can be used only from the age of three. Its optimal dosage is established on the basis of the patient’s age as follows: for therapeutic purposes, it is recommended that adult patients be administered 1,200,000 units and, in addition, 300,000 units once every four weeks; in the treatment of preschoolers, the optimal amount is approximately 480,000 units and 120,000 units once every three weeks; small patients, whose age is no more than eight years, need to enter the medicinal composition intramuscularly once every four weeks at a dosage of 960,000 units and 240,000 units.
It is necessary to prepare the suspension responsibly, in compliance with all the rules and using only sterile water that is intended for injection, a solution of isotonic sodium chloride or a solution of novocaine (procaine) from 0.25 to 0.5%. To prepare a suspension only before its direct use. Storage of the drug in its finished form and its subsequent use are strictly prohibited.
Doctors recommend administering the suspension to the outer superior quadrant of the gluteal muscle. In this case, after administration of the drug, it is better not to rub the injection site. The introduction must be carried out immediately after the manufacture of the suspension. Otherwise, you may encounter a transformation of the colloidal and physical signs of the suspension, and as a result, the passage of the drug through the needle will be difficult.
Side effects
Injections of “Bitsillin-5” according to the instructions should be done only after the appointment of a specialist and under his regular supervision due to the high probability of significant side effects. Patients most often encounter the following symptoms during treatment: dermatological lesions; fever; itching swelling; chills; hives; contact or exfoliative forms of dermatitis; laryngeal edema; bronchial asthma; anaphylactic shock, dangerous possibility of death in the absence of timely medical care; laryngospasms and bronchial spasms; serum pathology; bouts of vomiting and nausea; the development of glossitis, stomatitis, the appearance of a dark shade of the tongue; colitis, diarrhea, stagnation of bile in the body; the occurrence of interstitial type of jade; defects in blood pressure, as well as pump function of the myocardium, the appearance of tachycardia. Side effects can be avoided if you strictly follow the instructions for use of the drug and do not interrupt treatment in the middle of the course.
This is confirmed by the instruction and reviews on "Bicillin-5".
Analogues of the drug
The medication has analogues in the form of various kinds of benzylpenicillin salts produced in Russia. Other drugs based on penicillins are semisynthetic substitutes that are resistant to penicillinase and have antibacterial effects.
Such drugs, based on amoxicillin, ampicillin, which are available in the form of capsules and tablets, similar in composition and spectrum of influence, are Ampioks, Moldamine, Benzicillin-1, Augmentin, Retarpen, " Amoxiclav "," Extentsillin. "
Overdose of medication
Exceeding the correct dosages and prolonged therapy, side effects may develop due to toxic effects on the human central nervous system. We are talking about pains in the back of the head, reflex agitation, nausea, cramps, bouts of vomiting, symptoms of myalgia, meningism, arthralgia, the development of a coma. This is reported by the instructions for use and reviews of "Bicillin-5".
If the above symptoms occur, it is recommended to discontinue treatment and receive symptomatic treatment based on peritoneal dialysis and hemodialysis. In addition, there are violations of the water-electrolyte balance, the restoration of which requires special attention of the patient.
Drug Reviews
About the drug "Bicillin-5" patients respond mostly positively. The advantages of the drug, according to the responses, are low cost, duration of action, low toxicity and quick result. The disadvantages include the route of administration, which requires caution, the effect on the intestinal microflora, pain during administration and the development of undesirable effects. A number of patients say that the drug did not help and was ineffective, however, such situations are rare.
The article reviewed the instructions for use for humans "Bitsillina-5."