Lincomycin is produced in the form of a solution intended for intravenous and intramuscular administration. Pharmacological prescription is an antibiotic of the lincosamide group.
It is a colorless or yellowish liquid, has a thin specific odor.
Lincomycin, the instruction indicates, destroys the ability of bacteria to reproduce, which means it is a bacteriostatic substance. The effect of the drug does not apply to fungi and viruses, to gram-negative bacteria, to protozoa.
After administration, lincomycin hydrochloride quickly enters the body's tissues and fluids, bypassing the cerebrospinal fluid.
The drug penetrates the placenta, into breast milk.
Lincomycin, instructions for use
Prescribe the drug in the treatment of septic conditions caused by staphylococci and streptococci:
- acute and chronic form of osteomyelitis;
- pneumonia;
- suppuration of the skin;
- purulent infection of soft tissues;
- otitis;
- erysipelas.
Lincomycin is used to treat infectious diseases caused by other microbes that are sensitive to this drug. The drug is prescribed even in cases when other antibiotics, including penicillin, do not act on the pathogenic factor, or an allergic reaction is detected in the patient to one of the drugs attributed by the doctor with an antibiotic effect.
Lincomycin, instruction. Contraindications
The medication in question cannot be prescribed with hypersensitivity to this drug and to clindamycin. Pregnant injected with a solution of lincomycin hydrochloride only in cases of vital indications. With another set of circumstances, this antibiotic is considered contraindicated in women bearing a child. Mothers who are breastfeeding, for whom the doctor has prescribed a course of treatment with lincomycin, should stop lactation.
It is important to monitor the work of the liver and kidneys of those patients who take the antibiotic for a long course, while they have diagnoses associated with the above organs.
Lincomycin, instruction. Dosage
The daily volume for adults when administered parenterally is determined in the amount of 1.8 g, and a single dose is 0.6 g. The doctor can increase the daily dose of the drug to patients with severe diseases - 2.4 g. Linkomycin is administered every eight hours (3 times) .
The daily dose for children is prescribed in an amount from 10 mg per 1 kg of body weight to 20 mg of a child falling on 1 kg of body weight. When appointing, age is not taken into account.
With intravenous administration, the diffusion rate of the solution is from 60 drops to 80 drops in 1 minute.
In order to prepare Linkomycin medicine for a dropper, it is diluted with an isotonic sodium chloride solution at the rate of: 2 ml of a thirty percent solution of lincomycin hydrochloride (0.6 g of active ingredient) per 250 ml of sodium chloride in the form of a solution.
The duration of therapy is from 7 to 14 days. For patients with osteomyelitis, the doctor increases the course of treatment to 3 weeks. For patients who have kidney or liver failure, Lincomycin is prescribed in a dose of only up to 1.8 g per day. At the same time, the interval between the droppers is 12 hours.
About side effects
On the part of the digestive organs, the drug “Lincomycin” in rare cases can cause nausea, vomiting, pain in the abdomen, diarrhea, glossitis, exacerbation of stomatitis. Patients showed an elevated level of hepatic transaminases; bilirubin in high concentration was found in the blood plasma.
In some cases, with prolonged use of high doses of Linkomycin, the development of pseudo colitis was observed.
Disturbances in the circulatory system were caused by reversible leukopenia, neutropenia, thrombocytopenia, agranulocytosis. In very rare cases, doctors have indicated aplastic anemia and pancytopenia.
As allergic reactions, symptoms of urticaria, exfoliative dermatitis, Quincke's edema, anaphylactic shock were noted.
Possible exacerbation of candidiasis.