Consider the reviews of Diprospan for psoriasis. Usually, with such a serious skin disease, not only external agents are used to eliminate the symptoms and reduce the number of plaques, but also systemic drugs for internal administration or injection. In severe stages, inflammatory processes develop, exudate forms, which is accompanied by severe itching and other unpleasant symptoms. It is better to familiarize yourself with the reviews about injections from psoriasis Diprospan in advance.
Pathology Description
Psoriasis is a common chronic skin disease that is characterized by the appearance of a monomorphic rash of flat papules, which tend to merge into large plaques, which are covered with silver-white friable scales. The disease is characterized by a wavy course.
The etiology of psoriasis is not fully understood, however, scientists believe that the infectious, hereditary and neurogenic nature of the origin of this disease is most likely. The risk group includes people with frequent trauma to the skin, with disorders of the central nervous system, with the presence of streptococcal skin infections, endocrine pathologies.
The initial element of psoriasis is a single papule, pinkish, covered with white scales. At the stage of development of the disease, rashes are few, but their number is gradually increasing. The next stage is characterized by the appearance of new elements at the sites of injuries, scratching and abrasions on the skin. Newly formed elements begin to merge with existing ones, and form symmetrical plaques. In the third stage, the growth rate of plaques decreases, they become more clear from the border, the skin acquires a bluish color. Pronounced peeling is observed. Exudative psoriasis differs from ordinary psoriasis by the presence of crusts on plaques, which are formed as a result of soaking with exudate. Psoriasis of the soles and palms may also occur.
In severe forms of the disease, small intraepidermal pustules appear on the infiltrated skin, which merge and form purulent areas. According to reviews, "Diprospan" with psoriasis is very effective. This is noted by doctors.
What is the medicine "Diprospan"?
To similar symptoms of psoriasis, it is not enough only local medical. This requires the use of hormonal drugs, such as Diprospan. This is a glucocorticosteroid medication that is intended for the treatment of inflammatory diseases. It is often prescribed for complex forms for the treatment of psoriasis. Reviews about Diprospan will be presented at the end of the article.
Composition, release form
This medication is available in the form of an injection suspension: colorless or slightly yellowish, transparent, slightly viscous, containing suspended white particles, free from impurities. Upon dissolution, a white or yellowish suspension forms.
The composition of the drug contains the following active elements: sodium phosphate betamethasone and betamethasone dipropionate. Excipients are: sodium hydrogen phosphate dihydrate, disodium edetate, sodium chloride, polyoxyethylene sorbitan monooleate, methyl parahydroxybenzoate, benzyl alcohol, propyl parahydroxybenzoate, macrogol, sodium carmellose, hydrochloric acid.
The suspension is packaged in glass ampoules and plastic cell contour packs of 1 or 5 ampoules.
Pharmacological properties
Reviews about Diprospan injections for psoriasis are mostly positive. The drug has immunosuppressive (suppression of immunity), anti-inflammatory, anti-shock, anti-allergic and desensitizing (decrease in body sensitivity) effects. The active ingredient - betamethasone - in the medicine is presented in 2 forms: betamethasone disodium phosphate, which provides the speed of the onset of the desired effect, as well as betamethasone dipropionate, which serves to prolong the action of this medicine.
The widespread use of the drug in psoriasis and other diseases is due to its ability to suppress the production of substances that cause inflammatory reactions, block the inflammatory process at the cellular level. In addition, the drug has a slight ability to retain sodium in the body and increase the level of excretion of potassium, hydrogen and ammonium ions, but when used in recommended doses, such properties do not have clinical significance. This is confirmed by instructions and reviews about Diprospan injections for psoriasis.
Indications
The medication is recommended for use in psoriasis, as well as some complications caused by this pathology:
- psoriatic arthritis;
- erythroderma;
- generalized psoriasis.
In addition, injections can be prescribed for extensive severe skin lesions with plaques, when they form in large quantities, bleed heavily, and exudate. You cannot use Diprospan injections for psoriasis yourself. The decision on the need for medication can only be made by the attending physician.
According to the instructions, "Diprospan" is also prescribed for the following pathologies:
- diseases of the musculoskeletal system, including osteoarthritis, rheumatoid arthritis, bursitis, epicondylitis, ankylosing spondylitis, radiculitis and more;
- allergic diseases, including hay fever, bronchial asthma, rhinitis and more;
- dermatological diseases, including coin-shaped eczema, atopic dermatitis, neurodermatitis, contact dermatitis, photodermatitis;
- systemic diseases of the connective tissue;
- hemoblastosis;
- insufficiency of the adrenal cortex.
This list includes a host of other diseases that require the use of glucocorticosteroids.
Instructions for use "Diprospana" from psoriasis
This medication is used in the form of intramuscular injections, as well as for near- and intra-articular, intradermal, intracranial, intrabursal and interstitial administration. The small size of the crystals of betamethasone dipropionate allows the use of small diameter needles for direct introduction into the lesion. Injections should be carried out with strict adherence to asepsis, according to the instructions. "Diprospan" for psoriasis is administered and dosed individually, which depends on the indications, clinical presentation, severity of the pathological process and the patient's response.
With systemic use, the initial dosage of the drug in most cases is 1-2 ml. The course of treatment "Diprospan" from psoriasis should be repeated as necessary, taking into account the patient's condition.
How exactly do injections?
The most common way of introducing a drug into the body is intramuscular. How to prick "Diprospan" with psoriasis, it is better to find out in advance. The medication is injected deep into the large muscle, avoiding penetration into other tissues (to prevent the development of tissue atrophy).
In the presence of severe conditions that require emergency treatment, the initial volume of the suspension is 2 ml. With an ailment of moderate course and other dermatological diseases, in most cases, the introduction of 1 ml of the drug is sufficient. What else does the instruction for use in Diprospan injections against psoriasis tell us?
In addition, the treatment is applied topically. At the same time, the simultaneous use of a local anesthetic is necessary only in rare cases. If necessary, in a similar situation, use 1% or 2% solutions of lidocaine or procaine hydrochloride, or other similar substances that do not contain propyl paraben, methyl paraben and phenol. Mixing the liquids is carried out in a syringe - first of all, the necessary dosage of Diprospan is collected into it, after - the required amount of local anesthetic is collected with the same syringe.
With psoriasis, the introduction of a drug into the lesion site, which is evenly chipped with a tuberculin syringe and a needle with a diameter of not more than 0.9 mm, is also very effective.
After achieving the desired therapeutic effect, the maintenance dosage is selected by lowering the dose of betamethasone, which is carried out at intervals until the minimum dose is reached.
In case of a threat of occurrence or in the immediate occurrence of stressful situations (a risk factor for the development of exacerbation of psoriasis), an increase in the dosage of Diprospan suspension may be required. Drug withdrawal after prolonged treatment is carried out by gradually reducing the dosage.
Monitoring the patient's condition should be carried out at least for a year after the end of therapy or the use of the medication in high dosages.
With caution, the following groups of patients should be treated with Diprospana injections:
- People suffering from hypertension (high blood pressure).
- Those who suffer from serious disorders of the nervous system experience strong psychoemotional experiences.
- "Diprospan" and psoriasis are incompatible in the presence of purulent-infectious processes on the skin.
- Do not inject the drug to those whose skin is affected by viral and fungal infections.
- The drug is contraindicated in patients with type I and type II diabetes.
- People with osteoporosis.
- You can not do injections "Diprospana" with glaucoma, tuberculosis, thromboembolism, gastric ulcer.
A medication to combat the symptoms of psoriasis is prescribed in short courses. This is a strong drug, an overdose of which is fraught with a number of serious side effects. Reviews of the treatment of psoriasis "Diprospanom" confirm this.
Adverse reactions
The severity and frequency of adverse reactions when using a medical product depend on the dose used and the duration of the therapeutic course. These phenomena are usually reversible and can be stopped or reduced with lower dosages. According to reviews of Diprospan from psoriasis, the following are considered the most common adverse reactions.
- Metabolism: increased excretion of potassium and calcium, hypokalemic alkalosis, hypernatremia, negative nitrogen balance (as a result of protein catabolism), fluid retention in the body, lipomatosis (epidural and mediastinal, which can provoke neurological complications), weight gain.
- Heart and blood vessels: chronic heart failure (in patients with a predisposition), increased blood pressure.
- Musculoskeletal system: muscle weakness, decreased muscle mass, steroid myopathy, increased intensity of myasthenic symptoms in severe forms of pseudoparalytic myasthenia gravis, compression fractures of the spine, osteoporosis, aseptic necrosis of the head of the humerus or femur, tendon rupture, fracture of the bones, joint pain.
- Digestive system: erosive and ulcerative lesions of the mucous membranes of the digestive organs with possible further perforation and bleeding, flatulence, pancreatitis, hiccups.
- CNS: an increase in intracranial pressure with swelling of the optic disc (in most cases, at the end of therapy), cramps, dizziness, cephalgia, euphoria, depression (with intense psychotic reactions), mood swings, personality disorders, excessive irritability, sleep disturbances.
- Dermatological reactions: thinning and atrophy of the skin, impaired healing of wound surfaces, petechiae, increased sweating, ecchymosis, dermatitis, striae, steroid acne, a tendency to candidiasis and pyoderma, a decrease in reactions during skin tests.
- Endocrine system: menstrual irregularities, secondary adrenal insufficiency (especially during periods of stress during trauma, illness, surgery), decreased carbohydrate tolerance, Itsenko-Cushing's syndrome, steroid diabetes or manifestation of latent diabetes mellitus, increased insulin or hypoglycemia medicines, intrauterine growth disorders, delayed sexual development and growth in childhood.
- Organs of vision: increased intraocular pressure, glaucoma, posterior subcapsular cataract, exophthalmos; in some cases, blindness.
- Local reactions: hyper- or hypopigmentation, skin and subcutaneous atrophy, aseptic abscess.
- Allergic manifestations: shock, anaphylactic reactions, arterial hypotension.
- Other: flushing of the face after administration of the suspension, as well as neurogenic arthropathy.
Contraindications
Diprospan for the treatment of psoriasis is contraindicated in the following cases:
- systemic mycoses;
- introduction to infected skin surfaces and intervertebral space;
- s / c or in / in the introduction;
- high sensitivity to betamethasone.
This must be considered before the appointment. With caution, “Diprospan” for psoriasis can be pricked with cirrhosis, hypothyroidism, eye diseases of herpes etiology, with ulcerative colitis, abscess or other purulent infections, with intestinal anastomoses, diverticulitis, peptic ulcer disease, osteoporosis, arterial hypertension and thrombosis, thrombosis and thrombosis .
Special recommendations
In clinical medical practice, cases of the development of severe complications from the central nervous system (up to a fatal outcome) with the use of Diprospan from psoriasis are known. Among these complications, spinal cord infarction, quadriplegia, paraplegia, stroke and cortical blindness are distinguished. Since nothing is known about the effectiveness and safety of corticosteroids during epidural administration, this route of administration is not used. It is also necessary to avoid getting the drug into the vascular bed.
The method of application and the dosage regimen for psoriasis are established individually, which depends on the severity of this pathology and the patient's response. The medicine should be used in the minimum effective dosage. The period of application should also be the shortest.
The initial dose is selected until the desired therapeutic effect is obtained. After this, the dose of the drug “Diprospan” is gradually reduced to a maintenance dose. In the absence of a positive result from the treatment or during its duration, the drug is canceled, also slowly reducing the dose. According to doctors about Diprospan from psoriasis, this happens extremely rarely.
The introduction of the drug into the lesion site or into the structures of the soft tissues with a pronounced local effect can simultaneously lead to a systemic effect.
Given the likelihood of anaphylactoid reactions, it is recommended that precautions be taken before using the drug, especially if there is a history of allergic reactions to medications.
Diprospan contains two active ingredients, both of which are betamethasone compounds. One of these - sodium betamethasone phosphate - is a rapidly soluble fraction, due to which it is able to quickly penetrate into the systemic circulation. Therefore, consider the possible systemic effect of this drug.
Diprospan helps with psoriasis quite effectively. But against the background of the use of the medication, various mental disorders are possible, especially in patients with emotional instability or a predisposition to psychoses. When administered to people with diabetes, correction of hypoglycemic treatment is required.
Patients who receive this medicine should not be vaccinated against smallpox. Other immunization should not be given, due to the possibility of neurological complications and a decrease in the immune response. Immunization is possible with substitution treatment. Patients receiving the medicine "Diprospan" in dosages that inhibit the immune defense should be warned about the need to avoid contact with patients with measles and chickenpox.
Drug interaction
During the combined use of the drug "Diprospan" with phenobarbital, phenytoin, rifampin or ephedrine, an increase in the metabolism of betamethasone is possible with a decrease in its therapeutic effectiveness.
, .
.
, .
( ).
.
.
The simultaneous administration of the drug and somatotropin can lead to inhibition of the absorption of the latter. Below you will find reviews about Diprospan from psoriasis by doctors and patients.
The opinion of doctors
Medical specialists in the field of dermatology characterize the drug as a highly effective hormonal drug used to eliminate severe symptoms of inflammatory processes. According to doctors, “Diprospan” for psoriasis helps to quickly eliminate the manifestations of the disease, significantly reduce the likelihood of developing numerous complications, improve the appearance of the skin and the psychological state of the patient.
Nevertheless, doctors indicate a lot of side effects from the medication, among which there may be very life-threatening conditions. With this in mind, they warn patients that they should not be used on their own - before starting treatment, it is mandatory to consult a doctor who will study the clinical picture of the disease, conduct all the necessary diagnostic tests, and select the most suitable treatment tactics and dosage of the drug.
Patient Reviews
Regarding the pharmacological agent, in addition to doctors, numerous patients who suffer from such an unpleasant ailment and have undergone the course of therapy with this medication leave comments. Positive feedback from patients about Diprospan for psoriasis reflects the information that the medicine helps to relieve symptoms of the disease. Patients note that the inflamed psoriatic plaques heal quickly, the signs of inflammation disappear, the skin takes on a natural color and a healthy appearance. Since the drug has a hormonal nature of origin, an improvement in the condition of patients was observed quite quickly.
Negative reviews of patients about "Diprospan" from psoriasis in most cases describe a variety of side symptoms with the use of a suspension. Patients indicate the occurrence of dyspeptic phenomena that occur with the development of attacks of nausea, digestive disorders. These are the most common side effects from using the medication. Less commonly, various disorders in the functioning of the nervous system arose. At the same time, depressive states, mood changes, increased anxiety, headaches, and panic attacks were observed in patients.
We reviewed the instructions and reviews about Diprospan injections for psoriasis. We hope that now you understand the features of the medication.