In the article, we consider analogues and reviews for the Akkupro drug. This antihypertensive drug is intended for the treatment of arterial hypertension and chronic heart failure.
The active ingredient of this medication is quinapril, which is an inhibitor of angiotensin converting enzymes, an antihypertensive drug. ACE accelerates the conversion of angiotensin I to angiotensin II, which has a vasoconstrictor property and increases vascular tone, including as a result of stimulation by the adrenal cortex of aldosterone production. Hinapril inhibits this enzyme, reduces the synthesis of aldosterone. Due to the relief of the negative effect of angiotensin II on the production of renin by the principle of feedback, the activity of the latter increases.
Pharmacodynamics
A decrease in pressure leads to a decrease in total vascular peripheral resistance. At the same time , glomerular filtration and filtration fraction rates are insignificant or absent. This medication increases exercise tolerance. With prolonged use, it normalizes the blood supply to the myocardium with ischemia. Means "Akkupro" reduces platelet aggregation, improves the properties of coronary and renal blood flow. After a single dose, the hypotensive effect is observed after about 1 hour, reaching a maximum after 4 hours.
Analogues of "Akkupro" are no less effective.
Indications for the prescription of this drug
A medication is prescribed in the following cases:
- arterial hypertension (as monotherapy or when used together with thiazide diuretics and beta-blockers);
- heart failure of a chronic course, in parallel with cardiac glycosides and diuretics.
Drug properties
Pharmacological agent "Akkupro" has antihypertensive properties. It is effective for mild to moderate high blood pressure. Reduces pressure both in a standing position, and sitting. It begins to act an hour after administration, with virtually no effect on the rhythm of heart contractions.
Limitations and contraindications for the use of the drug
The list of contraindications for taking this medication includes:
- lactose intolerance;
- lack of lactase;
- glucose galactose malabsorption;
- pregnancy and lactation;
- age up to 18 years;
- hypersensitivity.
Careful reception
The medicine "Akkupro" is used with caution in the following cases:
- hyperkalemia
- aortic or mitral stenosis;
- obstructive hypertrophic cardiomyopathy;
- ischemic disorders in the heart;
- coronary insufficiency;
- severe heart failure in patients with an increased risk of arterial hypotension;
- symptomatic hypotension in patients who have previously taken diuretics and followed a diet with a limited intake of salt;
- circulatory failure in the brain;
- suppression of bone marrow hematopoiesis;
- diabetes;
- impaired functionality of the liver, kidneys;
- bilateral renal artery stenosis or artery stenosis of one kidney;
- conditions after kidney transplantation;
- the use of hemodialysis;
- severe systemic autoimmune diseases of the connective tissues;
- combined intake of potassium-sparing diuretics;
- extensive surgical interventions and the use of general anesthesia;
- the simultaneous administration of other antihypertensive drugs, inhibitors of the enzymes DPP-4 and mTOR.
Dosage
In the treatment of arterial hypertension together with diuretics, the initial dosage of the drug is 5 mg per day. With monotherapy, the drug is allowed in a dose of 10 or 20 mg.
Instructions for the use of analogues of "Akkupro" are of interest to many.
Side effects
When taking this antihypertensive drug, a variety of undesirable reactions are possible:
- pronounced decrease in pressure;
- signs of vasodilation;
- palpitations
- postural hypotension;
- angina pectoris;
- tachycardia;
- heart failure;
- cardiogenic shock;
- stroke, heart attack;
- paresthesia;
- sleep disturbance;
- cephalgia;
- dizziness;
- excessive fatigue;
- drowsiness;
- nervous excitability;
- depressive disorders;
- cough;
- pharyngitis;
- renal failure;
- hemolytic anemia;
- stomach ache;
- dyspepsia;
- flatulence;
- gastrointestinal bleeding;
- intestinal edema;
- hepatitis;
- backache;
- arthralgia;
- decreased potency;
- visual impairment;
- increased sweating;
- rash;
- exfoliative dermatitis;
- baldness;
- photosensitivity reactions;
- anaphylactic reactions;
- angioedema;
- generalized edema;
- eosinophilic pneumonia.
Price
The cost of this pharmacological agent is on average 390-410 rubles. It depends on the region and the pharmacy network.
Hinapril
This medication is an inexpensive Russian analogue of "Akkupro" and belongs to the class of ACE inhibitors. This is a special medicine, after which the body begins to produce a metabolite - quinaprilat. The positive effect of this medication is due to its powerful vasodilator effect. Rapidly suppressing the general processes of bradykinin metabolism, this medicine in a special way activates various kinin and depressor natural systems. With their participation, the basic properties that facilitate the patient's condition and reduce pressure, are realized.
This analogue of the drug "Akkupro" effectively reduces pressure, and this is often accompanied by a decrease in OPSS. At the same time, when using this medication, pathological changes in heart rate, cardiac output, and unstable renal blood flow are not observed. Among the equally important characteristics of the drug, the following can be distinguished:
- increased exercise tolerance;
- reverse development of cardiac muscle hypertrophy;
- improvement of the general blood supply of the ischemic myocardium;
- increased renal and cardiac coronary blood flow;
- decrease in platelet aggregation.
The positive effect of a medication starts about an hour after administration.
Captopril
This remedy for high pressure is a very cheap Russian analogue of Akkupro (costs 12-16 rubles).
This pharmacological product belongs to the group of ACE inhibitors. It inhibits the production of this enzyme, which catalyzes the conversion of angiotensin I to angiotensin II (a biological compound that causes spasm of the musculature of blood vessels with a narrowing of their lumen, an increase in peripheral resistance and pressure). This property leads to a decrease in pressure level due to a decrease in peripheral vascular resistance (afterload).
In addition, this medicinal product expands the arteries of the pulmonary system, as a result of which the blood flow in the lungs improves and the severity of preload decreases. By lowering peripheral resistance, the drug reduces the intensity of the load on the heart, reduces the likelihood of developing complications associated with high blood pressure. In addition, this drug dilates the arteries of the kidneys, leading to normalization of hemodynamics in them.
The Russian analogue of Akkupro is prescribed for hypertension, symptomatic hypertension, heart failure and diabetic nephropathy.
In addition, this medication is used in the treatment of heart attacks, angina pectoris and renal failure.
Lisinopril
The active ingredient of this Russian cheaper analogue of Akkupro is the same component. It suppresses the functionality of ACE, which reduces the level of blood pressure. This principle of action leads to the implementation of a number of diverse biological effects:
- decrease in vascular resistance;
- lowering blood pressure;
- reduction of preload on the heart;
- decrease in pressure in the capillaries of the lungs;
- increased minute volume of blood ejected by the heart.
Increased tolerance, resistance of the heart to stress, especially in people with insufficiency of this organ.
The tool "Lisinopril" to the greatest extent does not expand the veins, namely arterial vessels. Long-term use of this medication helps to reduce the severity of cardiac muscle hypertrophy (pathological expansion), improves myocardial nutrition, and also increases the average life expectancy of patients who have had a heart attack.
What are the indications of the Akkupro analogue? Taking the medication "Lisinopril" is indicated for a number of pathological processes in the cardiovascular system, which are accompanied by an increase in pressure. These conditions include:
- essential hypertension;
- combined treatment of chronic forms of heart failure;
- early complex therapy of a heart attack to maintain hemodynamic parameters.
In addition, the medication is used in the treatment of diabetic nephropathy, accompanied by damage to the renal vessels of the kidneys against diabetes mellitus. A photo of the Akkupro analogue is presented.
Enalapril
This medication is included in the list of analogues of the Acupro pressure medication. It has a cost significantly lower and is produced by Russian pharmaceutical companies.
The main active element of these tablets blocks the synthesis of angiotensin-converting enzymes, which are responsible for the level of pressure. Thanks to this, several basic properties of a medicinal product are realized, which include:
- reduction in pre- and afterload on the heart;
- resistance to blood flow in arterial vessels, as well as in the vascular beds of the lungs;
- increase in minute volume;
- increasing the resistance of the heart muscle to insufficient intake of blood, nutrients and oxygen.
Acceptance of the pharmacological agent "Enalapril" is indicated for the treatment of high blood pressure in patients with renovascular hypertension. In addition, this drug is used for the combined treatment of chronic heart failure.
We learn what doctors think about the analogues of the drug "Akkupro".
Reviews of doctors about the drug and its analogues
The medication is very popular today, not only among patients, but also among specialists who prescribe this medicine to their patients. Doctors knowingly prefer to prescribe this drug among all similar medicines. This is due, first of all, to the fact that the medicine is the most modern and adapted to the reception of patients suffering from numerous concomitant diseases. With an increase in blood pressure, according to doctors, it is most effective and affects the body more gently than others.
Experts also note the effectiveness of all of the above Akkupro analogues. Cheaper or more expensive to buy a substitute - it's up to you. However, according to practitioners, they are much weaker and give multiple adverse reactions, among which there are a lot of very serious conditions that are very dangerous for the patient's life. Among these negative phenomena, cardiac abnormalities are often observed, although the pharmacological properties of these drugs provide the opposite. In addition, these drugs are very toxic to the liver, seriously disrupt the functioning of the urinary organs and digestive system. This is confirmed by the instructions for use with the Akkupro analogues.
The most prescribed medicine among analogues is called the medicine Enalapril, which has been on the pharmaceutical market for several decades. He, unlike other analogues, does not have such a pronounced negative effect and, when used, adverse reactions are much weaker. Nevertheless, if we compare it with the Akkupro medical device, then doctors always give preference to the latter. The cost of this medicine is several times higher than that of modern analogues, however, the effect of its use is more noticeable, and it causes much less side effects.
We examined analogues and reviews of doctors for the “Akkupro” preparation.