The drug "Ofloxin" is a medication of a wide range of therapeutic effects, which is used in the treatment of tonsillitis to eliminate staphylococcal infection. This medicine has established itself as an effective drug in the antibiotic group. However, before use, you need to familiarize yourself with its composition, instructions and contraindications. In addition, the medication can be easily replaced with another antibiotic of foreign or Russian production.
Indications
What are the indications for the use of Ofloxin?
The use of the presented pharmacological agent is indicated in the treatment of infectious and inflammatory diseases, the occurrence of which is due to pathogenic microorganisms sensitive to the medication:
- pneumonia, bronchitis;
- meningitis;
- otitis media, sinusitis, laryngitis, pharyngitis;
- infectious pathologies of bones and joints;
- infectious damage to the soft tissues and skin;
- infectious and inflammatory diseases of the biliary tract, digestive organs and other structures of the abdominal cavity;
- oophoritis, endometritis, salpingitis, prostatitis, cervicitis, parametritis;
- cystitis, pyelonephritis, inflammation of the urethra;
- gonorrhea;
- infectious pathologies of the genital organs (orchitis, epididymitis, colpitis);
- chlamydia.
Prescription for prevention
For preventive purposes, this medication is prescribed for patients with neutropenia and other disorders of the immune system. In addition, the drug solution is used in the treatment of septicemia.
Cost
The price of Ofloxin is approximately 160 - 185 rubles. It depends on the region and the pharmacy network.
Analogs of Ofloxin
This antibiotic has a fairly wide range of analogues, however, they may differ in composition and indications. In order to figure out which medication is suitable in a particular case, it is necessary to consider each of them individually. The list of substitutes includes:
- Lomflox;
- "Zanocin";
- Vero-Ofloxacin;
- "Tarid".
Lomflox
This medicine is an analogue of Ofloxin and is produced in India. The release form is tablets, and the active element is represented by the substance lomefloxacin (in the form of hydrochloride).
This is an antimicrobial synthetic substance with a wide range of bactericidal effects from the category of fluoroquinolones. The principle of the drug’s action is due to the ability of the drug to block the DNA gyrase of a pathogenic bacterium by forming a complex with its tetramer, impaired replication and transcription of DNA, which contributes to the death of a microbial cell.
The substance lomefloxacin also has an intense post-antibiotic property, is active against microorganisms such as gram-positive and gram-negative aerobes, mycobacterium tuberculosis (located both inside and outside the cells), some strains of ureaplasma and mycoplasma, chlamydia. In an acidic environment, the effectiveness of this antibacterial element is reduced. Resistance to the drug develops slowly.
Once in the digestive tract after oral administration, lomefloxacin is completely absorbed, the maximum plasma concentration is observed after 2 hours.
Indications for the use of the drug are infectious and inflammatory pathologies, the causative agents of which are sensitive to it:
- infections of the joints and bones (including the chronic form of osteomyelitis);
- infectious damage to the epidermis and soft tissues;
- complicated pathologies of the genitourinary system of an infectious nature;
- gonococcal, mixed and chlamydial infections (both chronic and acute type);
- infectious enterocolitis and cholecystitis;
- otitis media;
- infectious damage to the lower parts of the respiratory organs (including chronic bronchitis and exacerbation of pneumonia);
- pulmonary tuberculosis (acute and progressive forms, multidrug resistance of mycobacteria, tuberculosis, poor tolerance of rifampicin and other inflammatory processes of non-specific origin).
In addition, the Lomflox medicine, the price of which we will discuss below, is prescribed for the prevention of infectious complications during transurethral surgery.
Contraindications to its use are cerebral atherosclerosis, epilepsy and other conditions with a predisposition to the development of seizures, age 15 years, pregnancy and lactation, high sensitivity to quinolones.
The price of Lomflox is quite high, compared with the main counterpart, and ranges from 400 to 430 rubles per pack.
Zanocin
The medicine "Zanocin" is an antibacterial drug from the category of fluoroquinolones. This is an analogue of Ofloxin Indian production.
Release form - solutions for infusions and tablets. The main active element is present in the composition of the medication - ofloxacin, which is an antimicrobial substance with a wide range of uses, which is part of the group of fluoroquinolones. The drug acts on bacterial enzymes, in particular, DNA gyrase, which is responsible for supercoiling, and changes the stability of DNA of pathogenic microorganisms. Violation of the structure of DNA chains provokes the death of malicious microbes. In addition, this substance has a pronounced bactericidal property.
According to the instructions for use for Zanocin, a variety of infections are indications for the use of a pharmacological agent:
- gynecological (including gonorrhea, chlamydia);
- urinary tract and organs;
- respiratory organs;
- ENT organs;
- visual organs of vision;
- skin, soft tissues and skin;
- digestive tract.
In addition, the drug is widely used in the treatment of endocarditis, tuberculosis (as part of complex treatment as a second-line drug), bacteremia. The Zanocin remedy is contraindicated at the age of up to 12 years, during pregnancy and lactation, with high sensitivity to the components. With caution, it is used in patients with CNS pathologies (epileptic syndrome, cerebral atherosclerosis).
The price of the medicine is approximately 200 rubles per package, depending on the place of purchase.
Vero-Ofloxacin
This medication is an analogue of the Ofloksin drug produced in Russia. A pharmacological agent based on the substance ofloxacin, which has an active antibacterial (bactericidal) property, is manufactured.
The medicine is completely absorbed from the structures of the digestive tract, penetrates the cells (macrophages, leukocytes) of most tissues and organs, creates large concentrations in bile, urine, prostate secretion, saliva, sputum, kidneys, lungs, gall bladder, liver, skin, passes through placental barrier and BBB. It is excreted by the kidneys. It has a wide range of therapeutic effects. It has a detrimental effect on gram-negative and some types of gram-positive pathogenic microbes.
In what cases is appointed?
A medication is prescribed in the following situations:
- severe infectious pathologies of the respiratory organs (lung abscess, pneumonia, exacerbation of bronchitis, bronchiectasis);
- diseases of ENT organs of an infectious nature (with the exception of acute forms of tonsillitis);
- infectious diseases of bones, joint structures, soft tissues, skin;
- pathology of the pelvic organs and abdominal cavity;
- renal infections of the kidneys, diseases of the urinary tract, reproductive organs (including prostatitis, gonorrhea);
- septicemia;
- chlamydial infections;
- conjunctivitis, ulcers of the cornea of bacterial origin;
- combination therapy of tuberculosis.
In addition, the medication is often prescribed for the prevention of infections in patients with immunodeficiency.
Contraindications to its use are high sensitivity to quinolones and fluoroquinolones, epilepsy, pregnancy and lactation, dysfunction of the central nervous system with a decrease in the level of convulsive readiness (after a stroke, traumatic brain injury, inflammatory pathologies of the central nervous system), age under 18 years.
There is a pharmacological agent in the range of 50-80 rubles.
Ofloksin's analogs and substitutes should be selected by the doctor.
The drug "Tarivid"
This is an analogue from the Indian manufacturer. "Tarivide" is an antimicrobial medication that is part of the group of fluoroquinolones, an extensive spectrum of exposure. The drug has a bactericidal property associated with the blocking of the DNA gyrase enzyme in pathogen cells. It is produced in tablet form, as well as in the form of infusion solutions.
Prescribe the drug "Tarivide" in the treatment of infectious pathologies:
- respiratory tract (with the exception of pneumococcal infections);
- ear, throat, nose (with the exception of acute tonsillitis);
- abdominal organs and bile ducts;
- urinary structures, kidneys, prostate gland, urethra (including infections of gonococcal etiology);
- pelvic organs;
- bones and joints;
- skin and soft tissues.
In addition, the medicine "Tarivide" is prescribed to patients with impaired immune status, patients with neutropenia, for preventive purposes.
Contraindications to its appointment are tendon lesions after treatment with quinolones, CNS pathology, epilepsy, convulsive syndrome, conditions after a stroke, age up to 18 years, pregnancy and lactation.
The price of the medicine is in the range of 390-420 rubles and depends on the region and the pharmacy network.
Reviews about the drug and its analogues
There are a lot of reviews about the drug, as well as about the analogues of Ofloxin. Patients characterize the medications presented as highly effective, but often complain of the occurrence of various adverse reactions. Among analogues, the most commonly prescribed drugs are Tarivid and Zanocin. These same tools are most popular among consumers.