The use of the drug "Omez DSR" is relevant for those who suffer from stomach problems. The tool is designed specifically to fight ulcers, and it also inhibits the production of gastric juice. The complex effect exerted by the active substances of the medication allows you to get good results in the treatment of stomach ulcers, duodenal ulcers.
Best for your health
Often, patients, having received a prescription for the drug in question, think about how Omez differs from Omez DSR? The price of these medicines is different. Why does the doctor prescribe just the second option?
The explanation is simple: "Omez" contains only one active substance, effective for ulcers, but "Omez DSR" in its composition has an additional component that makes therapy better, more effective. In addition, the tolerance of "Omeza DSR" is higher, that is, treatment is accompanied by fewer unpleasant side effects.
Treat - Do Not Cripple
As follows from the instructions for use "Omez DSR", this tool has a good effect not only in the treatment of gastrointestinal ulcers, but also with Zollinger-Ellison disease. The duration of therapy is usually short-term, the first improvements in the patient's condition are noticed after 4-5 days from the start of the course.
The instruction to "Omez DSR" calls for using the medication with extreme caution. In clinical trials, it was found that with renal failure, the likelihood of severe enough side effects is high. If the doctor makes a decision in this diagnosis to carry out the therapy with "Omez DSR", it is necessary to regularly monitor the patient's condition. Also, when developing a treatment strategy, it is important to remember a number of contraindications. All of them are listed in the instructions "Omez DSR".
How to be treated?
What is included in the composition of the drug (and in fact, in the composition of the difference is “Omeza DSR” and “Omeza D, except, of course, the price), what explains its quick, pronounced effect? Main active ingredients:
In one capsule, omeprazole is present in an amount of 20 mg, domperidone - 30 mg. There are also additional components that improve the process of assimilation of the drug, simplify the use of it by the patient and enhance the effect of active substances. Among the additional components in each capsule are sucrose, lactose and beckon, as well as talc and titanium dioxide. Many other compounds are also present. The full composition can be found out if you familiarize yourself with the instructions for use of Omez DSR.
When to take?
All indications and contraindications of the drug "Omez DSR" can be found in the instructions attached to it. Such an insert is necessarily present in the package containing the medication. In addition, the doctor, prescribing this remedy, also introduces the patient both to the reason why such a treatment option was chosen for him and to the dangerous factors that provoke negative effects when taking the medicine.
As a rule, “Omez DSR” is resorted to if an acid-dependent short-term health disorder complicated by nausea is diagnosed. Also, "Omez DSR" is indispensable for therapy (complicated by vomiting):
- gastritis;
- gastroesophageal reflux disease.
And when not?
The contraindications are described in detail by the instructions for use of Omez DSR. You can not resort to therapy if it is known that the patient’s body is hypersensitive to one or more of the substances that make up the drug.
Particularly noteworthy is the fact that the use of Omez DSR is not possible with high susceptibility to substituted benzimidazoles.
Instructions for use of the drug "Omez DSR" contains restrictions for women: therapy is prohibited during the period of gestation and breastfeeding. Also, the medication is not intended for children, it can be used only from 12 years old.
Omez DSR: compatibility with drugs and diseases
The main component of the drug - omeprazole belongs to the IPP group (stands for "proton pump inhibitors"). All compounds with similar properties should not be used in combination with nelfinavir. In addition, a strict ban is imposed on the use of Omez DSR (reviews confirm this) while taking medications that affect the duration of the QT interval to a greater extent. Also, a health hazard is the use of Omez DSR (instructions for use draws attention to this) and CYP3A4 inhibitors.
A number of diseases also impose restrictions on the possibility of drug therapy with Omez DSR. The manufacturer prohibits the use of the medication for:
- incorrect, insufficient functioning of the liver, kidneys;
- increased duration of conduction periods of the heart muscle, QT;
- electrolyte imbalance;
- prolactinoma.
Usage restrictions: the list goes on
Instructions for use, reviews of "Omez DSR" note that the tool can not be used if the patient's condition is suspicious of an increased risk of ventricular stimulation on the left. A dangerous situation develops with bleeding in the digestive tract, perforation. With increased danger, mechanical obstruction is associated.
In parallel with the drug “Omez DSR” (indications fade into the background), CYP3A4 inhibitors with a pronounced, strong effect cannot be used. In particular, simultaneous treatment with the described agent and ketoconazole, erythromycin is not allowed. If the patient is already undergoing therapy with any CYP3A4 inhibitor, it is necessary to notify the attending physician. As a rule, they are looking for an alternative to Omez DSR. Please note the difference between Omez and Omez DSR: in the second agent, domperidone is present in the composition, but both of them are unacceptable for therapy in the case of CYP3A4 inhibitors.
Compatibility with other medicines: know the enemy by name
For health, an increased danger is the simultaneous use of the medication in question and agents that affect the duration of QT. This means that you can not be simultaneously treated with "Omez DSR" with drugs containing:
- itraconazole;
- posaconazole;
- erythromycin;
- fluconazole;
- telithromycin;
- voriconazole.
In addition to these medicines, the ban on the use of "Omez DSR" imposes on the use of drugs "Ritonavir", "Telaprevir". Other names are possible that are incompatible with the described substance, therefore it is necessary to introduce a doctor into the course of therapy that a person is already undergoing, paying special attention to medications that affect the cardiovascular system. It is worth remembering that quite often new drugs appear on the market, and only a professional doctor knows the parameters of their compatibility with the Omez DSR under consideration.
How to use?
The scheme is usually chosen by the attending physician with an eye on the instructions for use "Omeza DSR". In the classic version, therapy involves using one capsule in the morning. The manufacturer recommends drinking the medicine an hour before eating. The tool must be used in the version as it is released. They do not chew the capsule, do not break, do not dissolve - it is necessary to swallow whole.
The digestibility of the active component of the drug depends on this.
No more than 30 mg of domperidone should be ingested per day. Therefore, the maximum dose of the drug for 24 hours is one capsule. The duration of such therapy is determined by the doctor, focusing on the tolerability of the drug and the presence of ulcer symptoms. The manufacturer regulates only the upper limit of the possible duration of regular use of the medication: 7 days.
Excess in the body: how is it expressed?
An overdose of omeprazole manifests itself:
- heart rhythm disturbance;
- sore head;
- loss of vision;
- dizziness
- obscure, confused, lost state;
- activation of sweat glands;
- gag reflex;
- nausea
Visually, you can notice that a person suffers from an overabundance of omeprazole, you can on the red face - blood rushes to the skin. The patient himself feels that his mouth is dry, apathetic, depressive. As a rule, patients complain of diarrhea.
An excess of domperidone: what is expressed?
If, when taking “Omeza DSR”, too much domperidone has accumulated in the body, this manifests itself in the following negative phenomena:
- disturbed heart rhythm;
- problems with orientation in space;
- dizzy;
- pressure rises;
- consciousness is disturbed;
- sleepy;
- the person is too excited.
Overdose: what to do?
To date, no specific antidote has been detected. If overdose cases are detected, it is necessary to assess the patient's condition, eliminate the most life-threatening symptoms and continue therapy, selecting medications that improve the patient's self-awareness.
Practice has shown that hemodialysis does not give a positive result. This is due to the increased level of binding to plasma proteins of the active components of the drug. Therefore, it is impossible to remove the excess "Omeza DSR" by this method.
Side effects
It is known that tolerance is high, as indicated in the instructions for the drug "Omez DSR" (there are analogues of this medication on sale, they will be listed below, but the real need for them is really rare). All side effects that are known to doctors are reversible, are classified as mild, and therefore can not serve as a reason for stopping treatment.
If the patient takes omeprazole for too long, the body can respond in a certain way. May occur:
- stomach ache;
- stool problems
- vomiting
- increased gas formation;
- dry mouth
- inflammation of the oral mucosa;
- candidiasis;
- violation of the taste buds;
- colitis;
- cramping
- problems with appetite;
- regurgitation.
What else is possible?
With an excess of omeprazole in the body, the liver, the system of organs that excrete bile from the body, can react to this. It is expressed by hepatitis. If metabolism turned out to be the weakest side, too high a concentration of omeprazole manifests itself as a lack of sodium, magnesium, calcium.
The central nervous system, PNS on the too long course of use of "Omez DSR" react:
- depressive states;
- headache;
- hallucinations are seen;
- consciousness is confused.
More often, such side effects are observed if the patient is seriously ill.
In some cases, when undergoing therapy against the background of a high concentration of omeprazole in the body, people become aggressive, overly excited. Others complain of tinnitus, possibly a state of vertigo.
Musculoskeletal system and skin: side effects
Incorrect use of Omez DSR, too long a course of administration, accumulation of the active component in the body can lead to malfunctions of these systems. Patients complain of:
- muscle weakness;
- allergies
- myalgia;
- arthralgia;
- urticaria;
- erythema;
- dermatitis;
- necrolysis;
- Stevens Johnson syndrome;
- hair loss
- increased sensitivity to light;
- itchy, rash-covered patches of skin.
Cases of anaphylactic shock, angioedema are known.
Unpleasant phenomena: what else to be prepared for?
When studying samples of patient fluids (in the laboratory) suffering from side effects when taking Omez DSR, non-standard parameters are detected. The levels of agranulocytosis, pancyto, thrombocyto, and leukopenia change.
The concentration of liver enzymes is increasing. This is characteristic of those who, before taking the Omez DSR course, were seriously ill with ailments affecting the liver. In some cases, signs of encephalopathy, hepatitis are fixed. Occasionally, patients experience manifestations of insufficient liver function.
The endocrine system can respond to the medication in question by gynecomastia. Immunity in rare cases shows increased sensitivity. Patients undergoing treatment often complain of malaise, a feeling of weakness without any specificity. Rarely, but cases of nephritis, bronchospasm, fever are recorded. The activity of sweat glands can be activated, swelling occurs. Visual acuity is lost. Violation is restored when the concentration of omeprazole in the tissues of the body is normalized.
Domperidone: specificity of adverse reactions
This active component "Omeza DSR" has its own list of side effects, slightly different from the above. Patients experience gastrointestinal problems, including changes in taste, heartburn, and upset stools. The nervous system reacts with lethargy, irritability, sleep disturbances, apathetic states or, conversely, excessive excitability.
An excess of domperidone can manifest itself as galactorrhea, menstrual problems and excess prolactin levels. Probably lengthening of the QT interval, a change in rhythm, heart rate. In rare cases, cardiac death was diagnosed. In comparison with the initially developed composition of the drug, the amount of domperidone per capsule was reduced to reduce the likelihood of adverse reactions from the cardiovascular system.
Domperidone: what other troubles are possible?
In some cases, the immune system reacts negatively to domperidone. This is manifested by allergic reactions. Perhaps the occurrence of a depressing psyche effect, manifested by depressive states, an increased level of anxiety. Patients become nervous, lose libido partially or completely.
In some cases, convulsions, a constant desire to sleep, and a general lethargic state were recorded. In some, the skin was covered with a rash, itching appeared. There is a chance of developing urticaria. In women, they can increase in size (slightly), the mammary glands become more sensitive, excretion and swelling are possible.
A number of patients were diagnosed with leg pain, dysuria, increased or delayed urination. Perhaps the development of infectious inflammation of the oral mucosa, eyes. In some cases, the concentration of cholesterol in the blood rises, the tests reflect abnormal indicators of liver performance. In the blood, the concentration of prolactin increases. The incidence of any of these side effects is 7% or lower. Almost all cases are easily tolerated, the symptoms disappear in a short time. The most serious unpleasant consequences of taking the medication disappear when the course of treatment ends or the dose is reduced.
What can be replaced?
If for any reason it is not possible to use the described tool, in agreement with the attending physician, you can replace it with a medication with a similar effect. Well-known analogues of "Omeza DSR":
- Pantex.
- Eno Lemon.
- "Panum."
The choice in favor of an alternative medication remains with the attending doctor. Self-correction of both the course of treatment and a single dose is not allowed, as indicated by the manufacturer in the instructions for use of the medication. You must understand that self-medication is dangerous to health and even life. The cost of one package of Omez DSR in prices for the current year is about 400 rubles.