The years go by imperceptibly and swiftly. More recently, a young girl proudly walked along the street with a school graduation certificate. It seems that quite a bit of time has passed, and already a young mother escorts her children to school. Years have passed, and now, grandchildren are already growing up. Autumn of life ... It is at this age that a woman is overtaken by such a formidable disease as postmenopausal osteoporosis. In this disease, bones become very fragile and prone to fractures. The modern pharmaceutical market is ready to offer its consumers a fairly large list of drugs that can successfully cope with this formidable disease. One of the most modern medicines is Bonviva.
Mechanism of action
The main active ingredient of the drug is ibandronic acid. This component prevents and inhibits the process of bone destruction. In addition, this substance inhibits the process of bone resorption (resorption) quite effectively, but does not directly affect the formation of bone tissue. In addition to ibandronic acid, the preparation as auxiliary components includes K-25 plasdon, lactose monohydrate, crospovidone, stearic acid, aerosil.
The medicine “Bonviva” describes the instructions for use as a tool that slows down the renewal of bone tissue in patients during menopause to the level at which they are in a woman of reproductive age. As a result, bone mass and bone mineral density increase actively, and bone collagen breakdown characteristics decrease. In general, ibandronic acid is a highly effective substance with a wide therapeutic range. For this reason, Bonviva can be used for periodic treatment and is characterized by sufficiently flexible dosing capabilities.
Medical reviews (Bonviva has already earned a good reputation in the pharmaceutical market) suggest that the drug is absorbed quite quickly in the gastrointestinal tract. After a period of time from 30 minutes to 2 hours in plasma, its maximum concentration is reached. From the blood, the drug in the amount of 40-50% of the total amount taken penetrates into the bone tissue and it accumulates there. Another part of the medication binds to plasma proteins. Everything else will be excreted by the kidneys.
According to clinical studies, the main component of Bonviva equally affects men and women. There are no obvious differences in the distribution of ibandronic acid between representatives of the European and Asian races. Patients of African descent have some differences in the distribution of the active substance Bonviva.
Main consumers
Bonviva tablets are available in three dosages: 2.5 mg, 50 mg and 150 mg. The drug at a dose of 2.5 mg is mainly used for the treatment and prevention of postmenopausal osteoporosis in women. A drug in a dosage of 50 mg is used in a much wider range of diseases. The main areas of therapeutic therapy include diseases such as metastatic damage to bone tissue (the drug should minimize the risk of hypercalcemia), fractures of a pathological nature. Pills in this dosage can also ease pain, reduce the need for radiation treatments for pain and fracture risks. Such doses provide therapeutic therapy to patients suffering from hypercalcemia against the background of malignant neoplasms.
150 mg tablets are Bonviva's most sought after drug. Instructions for use (the price is quite high, but this dose should be taken 1 time per month, which is very convenient) regulates the use of tablets for the prevention of fractures in postmenopausal osteoporosis in women. Clinical studies have shown that taking a single dose of 150 mg is as effective as daily use of 2.5 mg tablets for a month.
In addition to the above, another form of the drug "Bonviva" is widely used - injections. In most cases, the regimen is as follows: 1 injection in 3 months. I must say that the Bonvivan injection is quite aggressive, therefore, during treatment with this form, any side effects can be expected. Before direct use, the solution must be visually checked for impurities, pay attention to its color.
The drug is administered intravenously, in a jet, for 30 seconds. The procedure is carried out only by a medical professional. During its implementation, it is necessary to avoid getting the solution inside the artery and in the tissues surrounding the vein.
Application features
For patients suffering from osteoporosis, specialists usually prescribe 1 tablet (dosage - 150 mg) once a month. However, it is necessary to adhere to certain rules of admission so that the drug "Bonviva" acted as efficiently as possible.
A drug is very poorly absorbed if its intake is combined with a meal or with a drink (the exception is plain still water). As mentioned earlier, Bonviva tablets are taken once a month. But at the same time, it is very, very desirable that the drug be taken on the same day. If for some reason the day designated for taking the medicine was missed, then the pill should be taken at least during the next week. If this condition could not be fulfilled, then the reception should be postponed until the appointed day of the next month. Simply put, it is strictly unacceptable to use 2 tablets with a dosage of 150 mg for one week.
Take the medication at least 60 minutes before eating or before drinking anything. Chewing or dissolving tablets is not recommended, they must be swallowed whole and washed down with a glass of clean water (not mineral or non-carbonated). After the medicine has been taken, you should not lie down for 1 hour, the body should be in an upright position.
Contraindications to taking Bonviva
Like any other medication, “Bonviva” instructions for use (the price of the drug will be indicated below) are not recommended for patients with hypersensitivity to the components of the drug or even their intolerance. Medical specialists never prescribe medication to patients suffering from diseases such as achalation and stricture of the esophagus, hypocalcemia, glucose-galactose malabsorption. The use of the drug by people with galactose intolerance, lactose deficiency is unacceptable. In spite of the positive reviews, Bonviva is not prescribed for children and adolescents suffering from osteoporosis.
Very carefully, doctors prescribe the drug to patients who have problems with the gastrointestinal tract (ulcer, duodenitis, gastritis, dysphagia, Barrett's esophagus). In addition, any acute pathological processes in the stomach and esophagus should be the basis for drug withdrawal or, at a minimum, consultation with a specialist.
The medicine “Bonviva” (injections, tablets - any form of release) is not shown to pregnant women. The reason for this is the lack of clinical experience.
Overdose, side effects
After taking the first pill, some patients may experience mild flu-like symptoms. No special measures are required in this case.
If the dose is exceeded, certain side effects may occur. From the gastrointestinal tract, there may be such manifestations as diarrhea, dyspepsia, ulcer, duodenitis, gastritis. Quite often, “Bonviva” (instructions, patient reviews is proof of this) can provoke nausea, vomiting, abdominal pain, flatulence, dysphagia. With such manifestations, milk and antacids can be considered relative antidotes. You cannot try to artificially induce vomiting in order to avoid the risk of damaging the lining of the esophagus.
The musculoskeletal system can respond to medication with muscle stiffness and cramping, myalgia, arthralgia. In isolated cases, against the background of cancer, the risk of developing jaw osteonecrosis increases. Therefore, the dentist must be informed that his patient is taking “Bonviva” to assess the benefit / risk ratio and decide on the advisability of surgery at this stage of the treatment course.
Dizziness and headache may result in the nervous system responding to Bonviva. In addition, a number of allergic manifestations are possible, such as urticaria, skin rash, angioedema edema. Possible weakness, back pain. You should be aware that non-compliance with the dosage regimen can increase the likelihood of side effects from the digestive system.
Activities before starting a course of therapy
Before using any dosage of Bonviva, the instructions for use (the price depends on the form of release and dose) recommends paying attention to the level of calcium in the body. If there are manifestations of hypocalcemia, any other deviations from the norm of bone tissue metabolism and electrolyte balance, potential Bonviva consumers should take Ca 2+ and vitamin D in sufficient quantities. Taking some other bisphosphonates often provokes disturbances in the process of swallowing, the development of esophagitis, the formation of ulcerative lesions in the stomach and esophagus. To minimize these unpleasant manifestations, it is necessary to strictly follow the recommendations (the vertical position of the case for 60 minutes after applying Bonviva).
If there are signs of damage to the esophagus with Bonviva, the instructions for use (patient reviews are evidence of this) advises you to stop taking the medicine and consult your doctor.
During the course of therapy with Bonviva, the patient's diet should be rich in vitamin D and calcium. If there is no way to fully eat and ensure the intake of calcium and vitamin D with food, it is imperative to take appropriate medications.
Analogs
Currently, the most common drugs - analogues of Bonviva - are Bandronate and Ibandronic Acid Sandoz. They are analogues of the main active substance. A much broader group of drugs is similar to Bonviva in terms of its mechanism of action. These include the following medications: Bonefos, Alental, Veroklast, Zoleriks, Lindron, Ostealen, Risendros, Forosa, Fosamax. In order to replace the prescribed drug with Bonviva analogue (price, consumer reviews are not sufficient reasons), it is necessary to consult your doctor or pharmacist.
Price range
Despite the fact that Bonviva in tablets is produced by manufacturers in three dosages (2.5 mg, 5, mg and 150 mg), the tablet with the maximum dose of 150 mg is in the most widespread consumer demand. This dose is convenient for taking (1 time per month), but the drug is not cheap. 1 tablet can be purchased in the pharmacy chain for an amount in the range from 1650 rubles to 2120. The rest of the tablet forms are not in special demand, so finding them in pharmacies is quite problematic.
Bonviva injections have also gained a reputation in the pharmaceutical market and are finding their customers. Injections are even more burdensome for the patient than tablets with a dose of 150 mg: an injection according to the standard scheme is done once every 3 months. However, this form of drug release will cost the buyer a much more impressive amount than tablets. For 1 syringe tube for intravenous administration with a dose of 3 mg of Bonviva, the price in pharmacies can range from 5525 rubles to 5950.
Consumer opinion
Despite the fairly wide popularity of the drug “Bonviva” (instructions for use, the price - it must be said, a considerable one - confirmation of this), there are different reviews about the medicine. Both positive and negative. A small group of patients says that on the next day after the injection, the pain syndrome was quite clearly manifested: the whole body was sick, the muscles were reduced, the spine was sick. Some have rashes on the skin.
Quite often, you can hear from patients that after taking an unpleasant sensation, the gastrointestinal tract resembles itself. However, pain rarely reaches some critical value when special therapy is required to eliminate them. The positive effect of Bonviva compensates for the reaction of the gastrointestinal tract.
There are also positive reviews, "Bonviva" in which acts simply as a panacea for fragility and brittle bones. Too many patients notice obvious changes for the better on the part of bone tissue. For many, the back practically ceased to hurt, the stoop decreased, the gait became more confident and easier. And even those patients whose subjective sensations did not change anything, after the examination, they were convinced that the bone tissues had become denser.
More patients are very satisfied with the regimen of the drug. Despite the fact that the price of “Bonviva” bites, as they say, it’s very convenient to take one pill and forget about the treatment for a whole month. The same can be said about injections (1 time in 3 months). The main thing is not to forget about taking the next dose.
Some patients focus on the fact that at the very beginning of treatment with Bonviva medication, a condition similar to that which occurs with influenza infections was observed. However, this quickly passed, and, what can I say, compared with the threat of developing osteoporosis, such conditions are minimal troubles.
Some patients for whom the reviews of Bonviva, although deserving only positive, argue that a parallel intake with this drug "Calcium D3" had a negative effect on the digestive system.
Summarizing
Bonviva is a modern and highly effective drug designed to prevent the development of osteoporosis and the destruction of bone tissue. Despite the encouraging comments about the drug “Bonviva” (the instructions, the price of which were reviewed in the review), the reviews of patients who have already taken this medication should be remembered: the only reason for starting treatment is the instructions of the attending physician. It is important to find a doctor who will be as attentive as possible to assessing the health status of his patient and choosing the right dosage regimen. Only in this case, the risks of side effects will be minimized, and the drug will prove to be a highly effective treatment for osteoporosis and maintaining bone strength.