The Panangin Forte medication (the instruction describes in detail the principle of the drug's action) improves myocardial metabolism. They take pills for arrhythmias, restless sleep, coronary artery atherosclerosis, nervousness, finger numbness and other symptoms that are caused by a deficiency of potassium and magnesium in the body. To eliminate the lack of these substances will help "Panangin Forte."
The composition of the drug and the form of release
The drug is available in the form of tablets. Each contains 316 mg of potassium asparaginate, which in terms of potassium asparaginate hemihydrate is 332.6 mg and 280 mg of magnesium asparaginate, the amount of which in the form of magnesium asparaginate tetrahydrate is 350 mg. These are the main active ingredients of the drug.
Additional ingredients in the composition of the tablets are:
- corn starch;
- talc;
- magnesium stearate ;
- potato starch;
- povidone KZO;
- silicon dioxide colloidal.
The shell of each tablet contains talc, titanium dioxide, butyl methacrylate copolymer, macrogol.
The tablets are white and oval. On one side is the inscription "A83". The aluminum blister contains 15 tablets. In total there are 60 panangin Forte tablets in the package. Instructions for this medication are included.
The medicine is stored at a temperature of not more than 30 ° C out of the reach of children. Shelf life from the date of manufacture is two years. The manufacturer of the drug is the pharmaceutical Hungarian company Gideon Richter.
Pharmacology and pharmacokinetics of the drug
Consists of the main two active ingredients "Panangin Forte". The instruction notes that the drug can not be used without a doctor's prescription.
An important role in the preparation is played by magnesium and potassium cations. They are involved in the work of many enzymes, they are directly involved in the creation of inter- and intracellular structures, macromolecules with a special connection. Affect muscle contractility. Myocardial contractility depends on the proportion of calcium, magnesium, potassium and sodium ions.
Endogenous asparaginate acts as a conductor of ions, since it is similar to human cells. Dissociation of its salts occurs, after which ions in the composition of other compounds penetrate into the cell.
Potassium and magnesium asparaginate improve myocardial activity, and their deficiency can cause severe arterial hypertension, arrhythmia, coronary arteriosclerosis, and metabolic processes in the myocardium.
The Panangin Forte contains twice as many active substances as the regular Panangin.
Potassium and magnesium asparaginates are actively absorbed in the intestinal walls, especially in the small intestine. Excreted through the kidneys.
The medicine "Panangin Forte": application
The drug is used to compensate for the lack of potassium and magnesium in conjunction with other drugs for ischemic heart pathologies, including acute myocardial infarction. It is often prescribed for chronic heart failure. Indications for use are heart rhythm disturbances, this also applies to arrhythmias, which are caused by an overdose when using cardiac glycosides.
Contraindications
It is necessary to consider all contraindications before using the Panangin Forte tablets. Instructions for use contain detailed information about when you can not drink this drug.
As a rule, the medicine is not prescribed if there is excessive sensitivity to the active substances of the drug and its secondary components. It is forbidden to use the remedy for renal failure in acute or chronic form. Contraindications to use are hypermagnesemia and hyperkalemia, a violation of the metabolic functions of amino acids, as well as Addison's disease. Do not use "Panangin Forte" with atrioventricular block I-III degree, if there is a shock, including cardiogenic, and with low blood pressure. Do not prescribe the drug for myasthenia gravis in severe stages of development, hemolysis and acidosis. Do not use the drug for patients in a state of degradation, as well as for people under the age of 18, since the safety and effectiveness of the drug in this case is not confirmed by clinical trials.
Women can use the medicine during pregnancy when the potential health benefits of the mother are many times greater than the expected risk to the fetus.
Potassium and magnesium asparaginate has the ability to penetrate into breast milk, so breastfeeding should be interrupted during treatment with Panangin Forte.
Dosage and administration
Must be taken only after consulting a doctor with Panangin Forte tablets. Instructions for use notes that the drug is taken orally. The pills are swallowed whole, without chewing and drinking water. The medicine should be drunk after eating. This is due to the fact that the acidic gastric environment reduces its effectiveness.
Tablets are drunk one three times a day. The maximum daily allowance should not exceed three tablets. The duration of the course of administration is regulated by the doctor.
Side effects and overdose
All side effects should be considered when taking the Panangin Forte medication. The instruction describes in detail the negative phenomena that can occur with prolonged and improper use of the drug.
When using the drug, patients may experience a vomiting reflex, nausea, burning and discomfort in the epigastric zone. In some cases, there is an atrioventricular block, as well as paradoxical symptoms, which is expressed in an increase in the number of extrasystoles. Taking pills can cause hyperkalemia and hypermagnesemia, which are manifested in paresthesia, diarrhea, nausea and vomiting. Redness of the skin of the face also occurs, thirst appears, low blood pressure disturbs. Hyporeflexia and respiratory depression are sometimes observed. Cramps may bother.
An overdose of the drug is expressed in the manifestation of signs of hyperkalemia, which may be accompanied by excessive fatigue, heart rhythm disturbances, paresthesia, myasthenia gravis, confusion.
Overuse of this medication can provoke hypermagnesemia. This is a decrease in neuromuscular excitability, a gag reflex, lethargy, a significant decrease in blood pressure.
A sharp increase in the number of magnesium ions in the blood causes inhibition of tendon reflexes, can provoke coma or paralysis of the whole body.
In all of the above cases, symptomatic treatment is performed. Usually this is the injection of calcium chloride into a vein at a rate of 100 mg / min. If necessary, hemodialysis is performed.
special instructions
During treatment, patients with hyperkalemia should be constantly monitored and the level of potassium in the blood should be monitored.
With the simultaneous use of potassium-sparing diuretics, such as Triamteren or Spironolactone, as well as the joint treatment with beta-blockers, heparin, angiotensin-converting enzyme inhibitors, cyclosporine, non-steroidal drugs, the action of which is aimed at removing the inflammatory process, the likelihood of occurrence increases.
Combined potassium therapy in combination with glucocorticosteroids removes hypokalemia caused by the effects of the latest drugs.
Potassium reduces side effects from the use of cardiac glycosides. Increases the negative dromo- and batmotropic effects of antiarrhythmic drugs.
Magnesium in the composition of Panangin Forte reduces the effectiveness of tetracycline, neomycin, streptomycin, polymyxin B.
Anesthetics increase the inhibitory properties of drugs with magnesium on the nervous system. Combined use with succinyl chloride, Atracurium, suxamethonium and decametonium increases muscular-neural blockade. Calcitriol increases the amount of magnesium in the blood, and drugs with calcium reduce the result of the use of drugs with magnesium.
Medicines with astringent and enveloping properties, reduce the absorption of magnesium and potassium asparaginate in the gastrointestinal environment. When used together in therapy, a certain intake interval (3 hours) must be observed between using Panangina Forte with the above medicines.
Analogs
If necessary, you can always replace the Panangin Forte. The analogs are as follows:
- "Aspagin".
- Asparkam.
- Potassium and magnesium asparaginate.
- "Pamaton."
- "Panangin".
In order to avoid negative consequences, you should not replace one medicine with another on your own, since such decisions should be made only by a doctor.
Panangin Forte: difference from Panangin
The difference between "Panangin Forte" and the usual "Panangin" consists primarily in the concentration of active substances. In the first preparation, the content of potassium and magnesium is two times higher, therefore this medicine is taken one tablet 3 times a day, unlike Panangin, which is taken 2 pills three times a day. The increased content of active ingredients in the Panangin Forte drug also affected the price. The specified preparation costs twice as much as Panangin. The latter, in addition to the tablet form, is available in the form of a solution for injection. This drug has greater bioavailability than tablets.
The cost of the drug
The drug "Panangin Forte" can be purchased without a doctor’s prescription in each pharmacy. Its cost ranges from 300-350 rubles.
Reviews of patients and doctors
The instructions for use warns of the need to comply with the dosage when using the Panangin Forte product. Reviews say that the drug supports the cardiovascular system, helps with heart rhythm disturbances and removes leg cramps, swelling of the extremities, normalizes the work in the walls of the heart ventricles, replenishes the deficiency of potassium and magnesium, removes sharp changes in blood pressure. The results are already visible on the first and second day of use.
Among the shortcomings of the use of the drug, patients note the price and size of the tablet, because of which the medicine can be difficult to swallow. There are no negative opinions about the medication.
He says that you need to get acquainted with all the contraindications before taking the Panangin Forte remedy, instructions for use. Reviews of cardiologists about these pills are only positive. Doctors note that the medicine helps to normalize heart function and cope with chest pains, makes up for the lack of potassium and magnesium, and can be used to prevent a deficiency of these components. Due to the increased content of active substances, this drug is more effective than the usual "Panangin".