Arterial hypertension is a scourge of the modern population of the planet. A number of adverse external factors, poor ecology, constant stress, poor and irregular nutrition create the prerequisites for the development of cardiovascular pathology and the emergence of this formidable disease.
Modern pharmacy seeks to create drugs that, if they do not completely heal hypertension, will at least keep blood pressure under control, thereby minimizing the risk of myocardial infarction and strokes.
At present, such antihypertensive medicines as Hartil, analogues of this drug, which have been developed quite a lot, are in great demand by consumers.
Hartil
The manufacturer of the drug "Hartil" is a Hungarian company EGIS Pharmaceuticals PLC. Consumers are presented with three varieties of this medication: Hartil, Hartil D and Hartil Amlo.
The main active ingredient of Hartil is the substance ramipril. The underlying indications for using this drug are the presence in a person of diseases such as arterial hypertension, diabetic nephropathy, diffuse kidney diseases of a chronic nature. In addition, "Hartil" instructions for use (analogues in most cases will also give a positive effect) are recommended to be used to reduce the likelihood of developing myocardial infarction, "coronary death", strokes in people suffering from coronary heart disease (coronary heart disease). The use of Hartil is also practiced for those who suffer from cardiac insufficiency in its chronic stage and developed after the patient has had acute myocardial infarction (a prerequisite for using Hartil - stable hemodynamic parameters).
The drug "Hartil D" (analogues of the effect are available) consists of two active ingredients - ramipril and hydrochlorothiazide. The first component reduces high blood pressure, thereby reducing the load on the heart. The second substance is a diuretic that stimulates the elimination of salts and water through the kidneys, and, like ramipril, lowers blood pressure. Thus, "Hartil D" is prescribed for the treatment of hypertension in those cases when complex treatment with ACE inhibitors and diuretics is indicated.
The Hartil Amlo antihypertensive drug (analogues in composition and effect are produced by modern pharmacy) contains two main substances - ramipril and amlodipine. The purpose of this medication is practiced to treat arterial hypertension in those patients in whom concomitant use of ramipril and amlodipine has a positive effect both individually and in combination.
Ramipril-C3
The drug "Ramipril-C3" is an analogue of "Hartil" of Russian production. It is produced in Moscow by Severnaya Zvezda. The main active ingredient is ramipril. Magnesium stearate and lactose monohydrate are auxiliary.
The medication is prescribed for people with diagnoses such as arterial hypertension, heart failure (a chronic form and developed after acute myocardial infarction).
In such diseases, a prerequisite for the appointment of "Ramiplila-C3" - stable hemodynamics. Also, the indication for taking this analogue of the Hartil tablets is the presence of diabetic and nondiabetic nephropathy in the patient. With the expected good result, Ramipril-C3 is prescribed to people after surgery for transluminal coronary angioplasty and coronary artery bypass grafting (if the patient’s clinical standing is stable).
As a contraindication for taking this medication, individual hypersensitivity to the main or auxiliary components of the drug, the presence in the history of information about previously transferred angioedema caused by ACE inhibitor drugs are used. Ramipril-C3 is contraindicated for patients under 18 years of age, because no information on its safety and effectiveness.
Dilaprel
The antihypertensive drug Dilaprel is presented on the pharmaceutical market as the Russian analogue of Hartil. The main active ingredient is ramipril. As auxiliary, calcium stearate and colloidal silicon dioxide act.
Indications for the use of this medication: the presence in patients of diseases such as essential hypertension, cardiac insufficiency in the chronic stage (in combination with other medicines, in particular, diuretics).
The drug is prescribed for nephropathy (diabetic, non-diabetic), including when combined with proteinuria, hypertension. Dilaprel is also prescribed for use in those cases when, after a few days (2-9 days) after acute myocardial infarction, heart failure develops.
The medicine gives good results in those patients whose health condition is characterized by a high cardiovascular risk (sudden development of acute myocardial infarction, stroke).
The grounds for not prescribing this analogue (Hartil is characterized by practically the same contraindications) are considered to have a history of angioedema, hemodynamically significant stenosis of the renal arteries, stenosis of the aortic or mitral valves, arterial hypotension (low blood pressure), failure renal activity and the need for hemodialysis. "Dilaprel" is unacceptable in patients with chronic heart failure in the form of a stage of dec ensatsii and in the presence of nephropathy. In the acute phase of a heart attack the drug is not prescribed for unstable angina, pulmonary heart and serious ventricular cardiac arrhythmias.
Wazolong
This analogue (Hartil has the same main active ingredient - ramipril) has the following indications for use: hypertension (arterial, refractory, malignant, vasorenal), nephropathy (diabetic and developing against the background of chronic diffuse renal diseases).
It has a cardioprotective effect and significantly reduces platelet aggregation. The drug increases the sensitivity of tissues to insulin. Antihypertensive effect is felt after an hour and a half after taking the medication, the maximum effect is achieved after 5-9 hours, the duration of exposure is up to 24 hours.
Among the main contraindications for the use of this drug, hypersensitivity to the components (main and auxiliary) of the drug or to any other ACE inhibitors, the presence in the history of information about previously transferred angioedema provoked by treatment with ACE inhibitors can be distinguished.
During pregnancy, it is contraindicated to take this remedy, as well as Hartil. Instructions for use, reviews (Hartil analogues containing ramipril cannot be prescribed to pregnant women). Health workers recommend that you verify that you are not pregnant before starting treatment. If the patient becomes pregnant during therapy, medication with ramipril should be immediately discontinued and any other treatment method selected.
Amprilan
An ACE inhibitor such as Amprilan also has a Hartil analogue, both in composition and in its effect. The main active ingredient of the medication is ramipril. In the form of auxiliary components, sodium bicarbonate, lactose monohydrate, croscarmellose sodium, starch act.
The indications for prescribing this drug are, in general, almost identical to the previously described “Vazolong”, “Dilaprel”, Ramipril-C3 ”: hypertension, chronic heart failure, nephropathy, a decrease in the likelihood of developing cardiovascular disease.
The list of contraindications for the use of this drug is quite extensive. Amprilan is practically not prescribed for patients suffering from serious diseases such as bilateral stenosis of the renal arteries in a hemodynamically significant form and stenosis of the artery of a single kidney, renal failure, the condition after kidney transplantation and hemodialysis. The drug should not be used in patients with the following heart problems: aortic and / or mitral stenosis, chronic heart failure (decompensation stage), obstructive cardiomyopathy, and arterial hypertension.
It is unacceptable for women to take the medication during the period of bearing and breastfeeding the baby. Contraindication is the age of 18 years.
"Ramicardia"
Analogs of the drug "Hartil" are currently quite densely saturated the pharmaceutical market. Another well-known analogue is Ramicardia. Indications and contraindications for the medication are almost identical to the previously considered Amprilan.
Before starting treatment with this drug, experts strongly recommend examining the condition of the kidneys, because depending on the state of these organs, an individual dose for therapy is selected (or they completely refuse the drug). In the process of treatment with this agent, which is almost identical to the Hartil medication, the instructions for use (analogues, almost all can cause serious harm to the kidneys) recommends monitoring the state of the urinary system, electrolyte composition of the blood, the amount of renal enzymes and the picture of peripheral blood.
Those patients who have a deficiency of fluid, sodium, before starting to take "Ramicardia", it is necessary to eliminate all water-electrolyte abnormalities. In the course of treatment with this drug, hemodialysis using polyacrylonitrile membranes is unacceptable. there is a risk of anaphylactic reactions.
The Ramigamma
Widespread analogues of "Hartila" in Russia. Another such medicine is called the Ramigamma. The main active ingredient is ramipril. Indications and contraindications are similar to those characterized by the above described drugs. Therapy with this drug should be under the supervision of the attending doctor.
After the first dose of the Ramigamma has been taken, or the dosage of the patient’s diuretic taken has been increased, blood pressure should be measured as often as possible over the next 8 hours. This is necessary in order to prevent the development of an uncontrolled and rapid hypotensive reaction (drop in blood pressure). Close attention is required for patients suffering from serious diseases of the kidneys and cardiovascular system.
During treatment, it is necessary to control the level of leukocytes in order not to miss the moment of development of leukopenia.
Hartil, analogues of this medication (including Remigamma) should not be prescribed to those patients who are currently receiving desensitizing treatment (to reduce allergic manifestations to insect bites). The parallel use of ACE inhibitors and sensitizing agents can cause the development of a severe, life-threatening anaphylactic reaction of the body (respiratory failure, drop in blood pressure, vomiting, etc.)
Cardipril
Another one quite widely known drug is the analogue of Khartil - Cardipril. The active ingredient is ramipril. The main indications for the use of this medication are hypertension, congestive heart failure (as a component of complex therapy), nephropathy (including its initial stages), heart failure after myocardial infarction.
Contraindications for the use of "Cardipril" are quite extensive. The medication should not be prescribed for admission in the presence of renal and hepatic insufficiency, with systemic lupus erythematosus, renal artery stenosis, with hyperkalemia and hyponatremia, with inhibition of bone hematopoiesis. Do not prescribe the drug during pregnancy, lactation, and patients younger than 18 years of age.
With an overdose of “Cardipril”, severe hypotension (a drop in blood pressure), renal failure, serious electrolyte abnormalities, and shock may develop. To eliminate the consequences, it is necessary to conduct continuous monitoring and subsequent support of the basic functions of the body. With a strong pressure drop, an additional volume of sodium and liquid can be introduced. Hemodialysis will not give any significant effect.
Tritace
What else does the Hartil analogue have? Another drug widely known and used by patients is Tritace. The medication is available in Germany and France. The main active ingredient is ramipril. Indications for use, as well as contraindications, are approximately similar to all previously described ACE inhibitor drugs. Treatment with Tritace usually takes a fairly long period, the duration of which in each case is determined by the attending physician.
Before you start therapy with this medication, you must make sure that there are no conditions such as hyponatremia and hypovolemia. In the event that the patient has previously taken any diuretic drugs, they will have to be canceled or at least reduced in dosage 2-3 days before the start of treatment using Tritace.
After taking the first dose or increasing the volume of diuretics taken, the medical staff must necessarily ensure careful monitoring of the patient's condition for at least 8 hours. This is necessary in order to take appropriate measures if the blood pressure drops too rapidly.
If the patient has heart failure or a malignant form of arterial hypertension, it is permissible to start therapy with Tritace only in a hospital setting.
Throughout the entire period of treatment with this medication, it is necessary to monitor renal function, electrolyte concentration, hematological parameters (hemoglobin level, platelet count, white blood cells, red blood cells, white blood cell count).
Opinion of experts regarding ACE inhibitors
As with any serious medicinal product, to which Hartil and its best analogues can be attributed, reviews by a cardiologist, a doctor of any other specialization, or a patient can leave both positive and negative directions.
Most patients characterize Hartil himself and most of its analogues as very fast-acting drugs that are effective even with very high blood pressure. The duration of exposure to drugs of this group also reaches 24 hours. Although the prices for these drugs fluctuate very much, and not all medicines are available to a wide range of consumers.
However, there are negative opinions about the drug "Hartil." Analogues patient reviews are also sometimes characterized on the negative side. The reason is that all these drugs can cause the development of a whole bunch of side effects, some of which are quite severe. On this issue, medical specialists are in solidarity with their patients. Although the vast majority of medical professionals believe that such medicines have saved hundreds of lives and people really need them. The main thing is not to prescribe yourself medicines of this level on your own and clearly follow the recommendations of your doctor.