Many are interested in the Gino-Pevaril drug reviews and instructions. No one is safe from various fungal infections, and therefore, you need to know whether the use of this drug is allowed during pregnancy and with thrush. Fungal pathologies of the intimate sphere cause considerable discomfort, cause a feeling of itching, burning and an unpleasant smell. That is why an effective drug is required to deal with such a problem.
Reviews about "Gino-Pevaril" are mostly positive.
Structure
One suppository includes the active component of econazole nitrate in a dosage of 50 or 150 milligrams.
The excipient is solid fat.
Pharmacological features
Gino-Pevaril, unofficially also called econazole, is essentially a vaginal suppository. They have the shape of a torpedo; their color is mostly bright white or light white. One suppository includes either 50 or 150 milligrams of the active ingredient.
Pharmacodynamic properties
The drug has an extensive spectrum of influence. It actively eliminates several types of harmful microorganisms at once:
- yeast;
- dermatophytes;
- mold mushrooms.
In addition, it adversely affects gram-positive bacteria. The active component present in the Gino-Pevaril suppository also affects the fungal membranes of cells, as a result of which their damage occurs, and the permeability of cells of pathogenic microorganisms increases. The main enemy for econazole nitrate is unsaturated fatty acids belonging to the social class.
Good reviews of Gino-Pevaril can be found in large numbers.
Pharmacokinetics
The active component of the drug is poorly absorbed by the human body, no more than five percent of econazole nitrate fits into the walls of the vagina after administration of the suppository. The highest concentration of this substance, like its metabolites, is in the patient's blood in the first two days of therapy. The composition of the drug is 98% due to the composition of whey proteins. After oxidation, it undergoes an active metabolism. A similar effect will be caused by o-dealkylation, deamination. Metabolism products will exit through the digestive system and kidneys.
Indications for use
According to reviews, Gino-Pevaril candles are very popular. They are prescribed for the treatment of vulvovaginal mycosis caused by fungal microorganisms, infectious pathogens sensitive to the effects of econazole. In addition, it is used in the fight against other diseases of the female genital organs, provoked by yeast or fungi. Doctors recommend this drug for thrush. Reviews of "Gino-Pevaril" confirm that the drug quickly helps to get rid of the disease.
Contraindications
The main contraindication for treatment with a medicine is allergy, that is, high sensitivity to any substance in the composition of suppositories. Also, the use of Gino-Pevaril candles is impossible for the treatment of children under the age of sixteen. With extreme caution, it is necessary to treat those patients whose age is more than sixty-five years. Since studies of the reaction of women at such an elderly age to the medicine have not been carried out in the required amount, there is no verified information about its use.
During pregnancy
According to reviews, “Gino-Pevaril” is safe during pregnancy, but if used in the 2nd and 3rd trimesters.
With the intravaginal method of introducing suppositories, drug enzymes penetrate the patient’s circulatory system. That is why they are forbidden to use in the first trimester of pregnancy. The only exception is the extreme need for such treatment. However, this decision can only be made by the attending physician, who will carefully monitor the patient's condition.
Treatment with this drug in the second and third trimesters of bearing a baby is already less dangerous for the body. But the use of suppositories is allowed only if there is a guarantee of a specialist on the excess of the benefits of therapy over the alleged harm to the baby. Such treatment should be carried out under the supervision of a competent doctor or the use of analogues of the drug.
Studies of the reaction to the drug in women during breastfeeding have not been conducted, so there is no way to say for sure whether the drug passes into breast milk. Therefore, experts during lactation do not recommend treatment with Gino-Pevaril. If necessary, the treatment course should be under the supervision of a physician.
Instructions for use
Gino-Pevaril candles have only one method of application - intravaginal. Suppositories with a dosage of the active ingredient of 50 mg are administered as deep as possible into the vagina. This procedure should be carried out in a supine position before bedtime. The treatment course is two weeks. Subjective signs of the disease, such as white discharge and itching, can be eliminated earlier. The course of treatment, despite the improvements, is forbidden to interrupt and discontinue ahead of schedule.
Suppositories with a dosage of 150 mg are also administered before bedtime in the vagina. The duration of treatment with this form is three days. If a relapse occurs after the end of therapy or a positive result of a culture study, you need to repeat the course after a week break.
Side effects
According to reviews of Gino-Pevaril, the use of this medicine may result in such undesirable manifestations as burning, irritation of the vaginal mucous membranes, genital itching, rash in the lower abdomen, erythema. In rare situations, allergic manifestations in the form of urticaria and angioedema were recorded. By acting on the immune system, substances in the composition of the drug can cause hypersensitivity. Occasionally, peeling and contact dermatitis appear on the skin. In some cases, irritations, minor swelling, as well as unpleasant sensations of pain occur directly in the area of contact of the suppository with the mucous membrane in the female intimate organ. Unpleasant symptoms should be reported to the attending physician, who will decide whether to continue treatment or replace the drug with an analog.
Reviews about "Gino-Pevaril"
Reviews about this drug are mostly positive. Women report that the drug is well tolerated, rarely causes side effects.
However, in other comments there is mention that candles cause itching and burning. During pregnancy, the drug is safe, the main thing is to follow all the doctor's recommendations.