Mirtazapin Canon is a good new generation German antidepressant, which is produced by Organon International. The medicine is intended to combat depressive conditions. In addition, in small doses, it acts as a sedative. Sometimes the drug is prescribed for patients with sleep disturbance, as well as suffering from insomnia.
Compared to peers, Mirtazapin Canon has many different advantages. The composition includes only natural ingredients without synthetic additives. The drug is not addictive, which is characteristic of other sedatives. The effect of the drug persists for a long time. Mirtazapin Canon has established itself as an effective tool in the fight against depression.
Drug feature
"Mirtazapine Canon" refers to a group of drugs that affect mainly the nervous system. The drug is used for depressed conditions, as well as mental disorders. It can be either a means of monotherapy, or complement the combined treatment of disorders of moderate severity. It is not recommended to use this medicine without first consulting a doctor, as this can lead to serious mental health complications.
Mirtazapine Canon tablets are considered alpha-receptor inhibitors. They increase the transmission rate of norepinephrine and serotonin in the nervous system. The result of an antagonistic effect on histamine receptors will be the sedative effect of the drug. Subject to the indicated dosages, the medicine has practically no effect on the work of the heart and blood vessels.
The half-life of the drug is up to 2 days, and in older people this process can be longer. The drug is excreted along with urine and feces.
Composition and form of release
Mirtazapine Canon contains the main active component of mirtazapine. In addition, this medicine contains vitamins, biological additives, as well as components intended for better absorption of the drug: corn and starch.
The medicine is available in the form of coated tablets. They quickly pass through the patient's body without provoking irritation. Tablets are available in three dosages, namely 15, 30, 45 mg. They are oval in shape and covered with a yellow shell.
When a drug enters the human body, it is almost instantly absorbed. The bioavailability of the drug is 50%. Within two hours, the concentration of the drug in the blood plasma reaches its maximum level.
About 90% of the main component of the drug binds to blood protein, and its effect lasts 3 days. The effect of the drug is completely independent of the food that the patient consumes.
Indications for use
According to the instructions, Mirtazapine Canon is prescribed for the treatment of depressive conditions of different origin. They also include violations that arose against the background of:
- schizophrenia and psychopathy;
- somatic diseases;
- chronic pain syndrome.
The medicine is effective in relation to endogenous and involutional depression, decreased working capacity and depression.
In addition, Mirtazapine Canon 30 mg is prescribed for conditions such as:
- irritability and nervousness;
- suicidal thoughts;
- chronic depression;
- mental disorders;
- obesity associated with a nervous breakdown;
- frequent mood swings.
You can also use the drug for chronic fatigue, which is associated with a mild form of depression.
Mode of application
As stated in the instructions for use with Mirtazapine Canon, the tablets are swallowed completely, not crushed, washed down with water if necessary. You can drink them at any time, regardless of food intake. The initial dosage for adults is 15–30 mg daily in the evening. The maintenance dose is 15–45 mg.
Elderly patients do not need to adjust the dosage. With liver and renal failure, the elimination of the drug slows down, therefore, the doctor should calculate the optimal dosage taking into account the severity of the violation.
The daily amount of the drug can be divided into 2 doses. The morning dosage should be less than the evening. When taking Mirtazapine Canon 30 mg, signs of depression usually disappear within the first two weeks of therapy. A properly selected dosage of the drug allows you to achieve a steady state in the first month of treatment.
If the desired result does not appear within the first 14 days, then gradually you can increase the amount of the drug under the supervision of a doctor. After achieving the desired effect, the drug is continued for another 1 year to consolidate the result. It is impossible to abolish Mirtazapin Canon. It is necessary to gradually reduce the dosage until the cessation of its use. The treatment period for prolonged depression is about 6 months.
Contraindications
As stated in the instructions for use, "Mirtazapine Canon" is forbidden to drink with hypersensitivity to the active component or any components. Not recommended for use in pediatrics.
In addition, it is not recommended for use under conditions such as:
- current use with MAO inhibitors;
- drug abusers;
- hypertensive and hypotensive;
- with violation of the urination process;
- suffering from alcoholism.
Also, this drug is not recommended for those who suffer from glaucoma or increased intraocular pressure.
Side effects
Before using Mirtazapine Canon, the instructions for use and reviews must be studied without fail, as there may be certain contraindications and side effects when using this medication.
Adverse events may mask the symptoms of depression. To determine the exact cause of this condition, a consultation with a psychotherapist is required. Undesirable manifestations can be divided by the frequency of occurrence and the systems that are affected. These include such as:
- inhibition of hematopoiesis, thrombocytopenia, anemia;
- increased appetite, weight gain;
- irritability, anxiety, hallucinations;
- distraction, drowsiness, dizziness, headache;
- pressure reduction;
- nausea;
- allergy;
- joint pain.
Abrupt cessation of treatment with an antidepressant can lead to withdrawal symptoms. Often it passes on its own, but is accompanied by irritability, nausea and anxiety.
special instructions
As stated in the instructions, "Mirtazapine Canon" should not be taken with alcohol. In some cases, while taking antidepressants and alcohol, suicidal tendency was observed. With a sharp withdrawal of the drug, headache and nausea may occur.
The intervals between taking an antidepressant can be increased, but this drug can only be completely abandoned after a while. You need to be very careful when prescribing the drug to people suffering from schizophrenia or other mental disorders, since it is possible to increase the symptoms of diseases.
Patients with suicidal tendencies throughout the course of therapy should be under the supervision of a physician. At the initial stage of treatment, suicidal tendencies may increase. This risk also remains at the stage of recovery, as the patient goes through an acute stage.
At the very beginning of treatment for a person prone to suicide, it is necessary to prescribe the lowest possible dosage of the drug, which is then gradually increased. Patients over 70 years old need to be very careful while taking the drug. In some cases, there is a sharp decrease in the level of white blood cells in the blood.
If bone marrow is inhibited, antidepressant treatment should be stopped immediately. It is worth paying attention to symptoms such as:
- sore throat;
- stomatitis;
- fever.
In this case, the therapy is stopped and a blood test is prescribed. The same goes for hepatitis. In this disease, the use of the drug "Mirtazapine Canon" must be stopped immediately. If a person has epilepsy or other brain damage, then medication should be minimal. With an exacerbation of the disease, antidepressants are canceled.
The drug can increase the blood sugar level of patients with diabetes. In this case, the drug is not stopped, but the amount of insulin is increased. The patient is transferred under close supervision by the attending physician.
Mirtazapine Canon is not prescribed for complex hereditary diseases, in particular, such as lactose intolerance. During the course of therapy, it is not recommended to drive a car or other vehicle. The same applies to people whose professions require increased concentration of attention and speed of reaction.
During pregnancy, the medicine can be used only in case of emergency. There were no obvious adverse events, however, there is still a chance of complications in the fetus. And also do not use antidepressants during lactation.
Drug interaction
In some cases, Mirtazapine Canon is combined with other drugs. However, prior consultation with your doctor is required, as side effects may occur.
Simultaneous administration with Levodopa can provoke the development of severe psychosis. In combination with benzodiazepine-based agents, sedation is enhanced. When combined with Clonidine, there may be a hypertensive crisis.
It is worth paying attention to the fact that you can not combine it with MAO inhibitors. After the use of inhibitors, you need to wait a couple of weeks and only after that start taking antidepressants.
Analogues of the drug
Analogues of the drug must be selected along with the attending doctor. In this case, the peculiarity of the pathology course is taken into account. The following drugs will be similar in composition and principle of action:
- Mirzaten.
- Mirazep.
- "Remeron."
- Mirtastadin.
- Esprital.
Instructions for use and reviews of Mirtazapine Canon indicate that this is a very good drug that is used to treat mild depression. However, it has certain indications and contraindications, which is why replacement with analogues is required.
Among them, the drug "Azafen" should be distinguished. It belongs to antidepressants of plant origin. It fights insomnia well and increases the level of serotonin in the blood. It calms, eliminates anxiety and improves mood, and also improves mental health. The active component of the drug acts to increase norepinephrine and serotonin in the nervous system. Prescribe the drug in courses. In case of an overdose, headache, nausea, and dizziness may occur.
The drug "Pyrazidol" produced in Russia is prescribed for schizophrenia, depression, and also affective bipolar disorder. The medicine is similar to "Mirtazapin Canon", therefore it is used for the symptoms of neurosis, as well as depression, accompanied by psychomotor inhibition. It can be used in combination with other antidepressants, with the exception of monoamine oxidase inhibitors only. Another indication for use is Alzheimer's disease and withdrawal syndrome.
The drug "Neuroplant" is a drug, which contains St. John's wort extract. It is intended for the treatment of psycho-vegetative disorders and depressive conditions. The medicine helps to improve mood, normalize sleep, increase physical and mental performance. The remedy is contraindicated in severe degrees of depression, as well as allergies to components. When working with mechanisms, as well as managing transport during therapy, care must be taken.
Calixta belongs to the group of antidepressants. It is similar to "Mirtazapine Canon", since their active substance is the same. Indications for use are depressive conditions. 1 tablet is prescribed daily. You can divide it into 2 parts and drink it in the morning and in the evening. The drug is not prescribed for children under 18 years of age. Among the side effects, it is necessary to highlight an increase in appetite, drowsiness, dry mouth.
Many are interested in, “Remeron” and “Mirtazapine Canon” are the same or do they have different active ingredients? The drug "Remeron" has the same composition and the same effect. The medicine is prescribed 1 tablet daily. At will, it can be divided into 2 doses. The drug is not recommended to be taken simultaneously with monoamine oxidase inhibitors, since the frequency and severity of side effects may increase. During treatment, it is forbidden to drink alcohol.
Reviews
Among the reviews of patients taking the drug "Mirtazapine Canon", one can find both positive and negative statements. First of all, they highlight the effectiveness of the drug. Within a week from the beginning of its intake, you can notice an improvement in well-being. As a negative review, complaints of drowsiness and increased fatigue are mainly found.
As the patients themselves say, the next morning after taking it, it is very difficult to wake up. It’s hard for people of mental labor to concentrate while working. The head is clouded. Many people note an increase in appetite and the occurrence of problems with the swallowing process. However, the most complaints about a decrease in immunity.
According to reviews taking the drug Mirtazapin Canon, they became much more likely to get colds. Many say that this medicine helps to quickly and effectively cope with prolonged depression, accompanied by lethargy and insomnia. The condition is normalized, all experiences, and mental problems go away. After taking the drug, there are absolutely no side effects.
Patients' reviews of Mirtazapine Canon indicate that this is a pretty good antidepressant, but when taking it, there may be a problem of gaining excess weight. When applied, there is a constant feeling of hunger. In general, the drug is pretty good, as it helps to cope with neurosis, improves overall health, normalizes sleep, invigorates.
Doctors' reviews of Mirtazapine Canon say it is a good antidepressant with a pronounced hypnotic effect. The medicine is used to combat suicidal tendencies and depressive states. Doctors' reviews about this drug are not so optimistic, but most experts still do not find a more effective replacement for it.
The active substance of the drug is mirtazapine. It is sold only by prescription. Unlike most drugs, this is really dangerous, which is why the doctor prescribes it only if you are sure that the person is suffering from depression. In addition, it is worth noting that its effect on the psyche has not yet been fully studied, since all ongoing processes are very difficult to verify. It is impossible to say exactly how the drug will work in the event of depression and whether it will cause a reverse effect.
The instructions for use of the drug indicate that it can provoke many side effects, as well as an indication to drink it only under the supervision of the attending doctor. Moreover, in the first days of taking the medicine, there may be a deterioration in well-being and literally clouding of the mind.
It should be noted that side effects do not decrease with a decrease in the dosage of the drug, only its antidepressant effect becomes less.
Self-medication with this drug is strictly prohibited, as this can only provoke a deterioration in well-being, and will not bring any result. And it is also important to strictly adhere to the dosage.