This article will present instructions for use with Valz 40, 80 and 160 mg dosage.
This medication is a tablet preparation based on valsartan. Assign it as part of the treatment of arterial hypertension. It is also suitable for the treatment of chronic heart failure. The cost of the drug ranges from four hundred to nine hundred rubles. There are contraindications, and adverse reactions are also possible. Next, we familiarize ourselves with the instructions for using the Valz medicine, as well as its analogues and find out what people write in reviews about this medical device.
Composition of the tablets
The tablets are coated with a special coating. The active substance is valsartan. One tablet of the drug may contain 40, 80 or 160 milligrams of the active ingredient. Excipients are lactose monohydrate, microcrystalline cellulose, povidone, talc, magnesium stearate.
Also on sale you can find the drug "Valz N". An additional component of hydrochlorothiazide is present in the composition of the medication, which provides an additional diuretic effect.
Instructions for use with "Valzu N" (80 / 12.5 - the ratio of two active substances) confirms this.
Pharmacodynamics of the drug
A peripheral vasodilator is capable of exerting a hypotensive effect. The drug does not affect the content of total cholesterol. Also, it does not affect the amount of triglycerides, urea and glucose in the blood. The onset of the effect is usually observed two hours after administration. The latest effect may occur after six hours. The total duration of exposure to the body is twenty-four hours. Against the background of regular use, the maximum decrease in pressure in patients occurs after four weeks. In the event of a sudden cessation of intake, there is no withdrawal syndrome.
Pharmacokinetics of the drug
According to the instructions for use with Valz, after internal administration, absorption occurs quickly, the degree of absorption is variable. The average absolute bioavailability is 23 percent. The pharmacokinetic curve of the active substance is characterized by a downward character.
Within the range of dosages studied, the kinetics of valsartan is linear. Against the background of repeated use, no changes in kinetic indices are noted. As a result of taking the dosage once a day, a slight degree of cumulation of valsartan may be observed. The concentration of the active substance in the blood plasma does not have any differences in women and men.
Valsartan can bind well to plasma proteins. It mainly binds to serum albumin. If equilibrium is reached, the total volume of distribution will be 17 liters. Compared with hepatic blood flow, plasma clearance of the active component of the drug is quite slow. The drug is usually excreted with bile. Excretion occurs unchanged. Hydroxymetabolite is fixed in the blood plasma in low concentrations. After taking 83 percent of valsartan, it is excreted by the intestines. Thirteen percent is excreted by the kidneys. This is confirmed by the instructions for use with Valz 40 mg. The same information is contained in the annotation for drugs with a higher dosage.
Starting from approximately the eighth hour after taking the drug, the concentration of the active component in the blood plasma remains the same regardless of whether the drug was taken on an empty stomach or together with food. Thus, the presented drug can be used regardless of food intake.
Indications for use
In accordance with the instructions for use, Valz is prescribed to patients in the following cases:
- The presence of arterial hypertension.
- The development of chronic heart failure.
- The need to increase patient survival against the background of acute myocardial infarction, which is complicated by the development of left ventricular failure.
- The development of systolic dysfunctions of the left ventricle, subject to the presence of stable hemodynamic values.
This is described in detail in the instructions for use. At what pressure is Valz prescribed? Pills are effective when you need to lower blood pressure and keep it normal.
Next, we will understand what contraindications exist for this drug.
Contraindications to the use of the medication
As indicated by the instructions for use, "Valz" has many contraindications. It is not suitable for use in the following cases:
- The presence of hypersensitivity to valsartan or to auxiliary components of the drug.
- Dysfunction of the liver, which are associated with general obstruction of the biliary tract, for example, with biliary cirrhosis, cholestasis, and so on.
- The presence of severe renal failure.
- Patients who are on hemodialysis.
- The period of gestation and breastfeeding.
- Patients are under eighteen years old, since efficacy, as well as safety, has not been established for younger categories of patients.
- Patient intolerance to lactose.
- The presence of galactosemia or malabsorption syndrome of galactose.
With caution, this drug should be used for arterial hypotension, hyperkalemia, a diet with a limited intake of sodium, hyponatremia, and bilateral renal artery stenosis. Also, caution should be exercised in the case of the use of this medication for artery stenosis of one single kidney, and in addition, against the background of primary hyperaldosteronism and hypertrophic obstructive cardiomyopathy. Not the best way to use the tool and in conditions accompanied by a decrease in the amount of circulating blood.
Instructions for use with Valz are very detailed.
Pregnancy Use
There are no data on the use of valsartan during pregnancy. Renal perfusion of the bearing fetus, depending on the development of the angiotensin system, begins to fully function in the last trimester. The risk to the fetus may increase if you take valsartan in the middle and at the end of pregnancy. Thus, if pregnancy is established, treatment with valsartan should be stopped immediately.
There is no data on the release of valsartan into mother's milk. In this regard, breastfeeding should be discontinued if a woman is forced to take the drug.
This is confirmed by the instructions for use with Valz 160 mg. The same information is contained in the annotation for drugs with a lower dosage.
Dosage and administration
This drug is taken orally, regardless of the intake of products. It should be washed down with a sufficient amount of water.
With arterial hypertension, the recommended initial dosage of Valza is 80 milligrams only once a day. The antihypertensive effect, as a rule, develops in the first fourteen days of therapy. The maximum effect can be achieved after a month of taking the drug. In patients for whom a daily eighty-milligram dosage does not give the desired therapeutic effect, an increase in the norm to 160 milligrams is recommended. In addition, another antihypertensive drug, such as a diuretic, can be prescribed to such patients.
Against the background of chronic heart failure, the recommended initial dosage of the drug is 40 milligrams twice a day. In case of insufficient therapeutic effect, patients require a gradual increase in dosage to 80 milligrams twice a day. And with good tolerance, the amount of active component can be increased to 160 milligrams twice a day. From the moment of initiation of therapy with this medicine to the achievement of the maximum dosage, an interval of at least two weeks should be maintained. The maximum daily dose is 320 milligrams in two divided doses. Dosage reduction is likely due to the simultaneous administration of diuretics.
This is stated in the instructions for use. Reviews about the Valza are abundant.
It can be used in combination with other medical devices that are intended for the treatment of chronic heart failure. True, taking Valza in combination with inhibitors is not recommended.
This medication is suitable for patients who have had myocardial infarction. With stable hemodynamic parameters, therapy can be started within twelve hours after a heart attack. The initial dosage is half a tablet, that is, 40 milligrams twice a day. Then you can increase the dose to 40, and later to 80 mg or 160. Instructions for use with "Valz" contains this information.
Achieving a dosage of 80 milligrams is recommended by the end of the second week of treatment. 160 milligrams should be taken by the end of the third month of therapy. Dosage should be increased based on patient tolerance of this drug. In the case of the development of symptomatic hypotension or against a background of impaired renal function, the dose of the drug should be reduced.
This drug is also suitable for impaired renal or hepatic function. In patients with mild hepatic impairment without the development of cholestasis, the daily dose of the drug should not exceed 80 milligrams.
Side effects
The heart and blood vessels often respond with orthostatic hypotension, and sometimes a strong decrease in pressure. Side effects in the form of heart failure, vasculitis and bleeding are not ruled out. The respiratory system may respond with a cough. Digestive organs can respond with diarrhea, abdominal pain, and very rarely nausea. This is confirmed by the instructions for use and reviews to "Valz 80 mg." The same information is contained in reviews about drugs with a different dosage.
The nervous system often responds with postural dizziness, sometimes fainting, insomnia, depression, decreased libido, neuralgia, and less often headaches. On the part of the activity of the hematopoietic organs, patients often have neutropenia, and thrombocytopenia is much less common.
As part of allergic reactions, serum sickness can be observed along with hypersensitivity. It is extremely rare for a skin rash or itching. The musculoskeletal system sometimes responds with the appearance of back pain. Muscle cramps, arthritis, myalgia, arthralgia, and so on are also possible. Quite rarely, patients have impaired renal function and the development of insufficiency of this organ. On the part of the metabolism, hyperkalemia is sometimes fixed.
Among other things, among the adverse reactions of the body, a feeling of fatigue can occur along with asthenia, nosebleeds, edema, and so on. On the part of laboratory parameters in humans, a decrease in hemoglobin and hematocrit is recorded. Hypercreatininemia can also be noted along with hyperbilirubinemia, an increase in hepatic transaminase activity, an increase in nitrogen concentration, and so on.
The same side effects and the "Valz N". Instructions for use are also reported.
Drug overdose
Symptoms of an overdose will primarily be manifested in a pronounced decrease in pressure, which can lead to loss of consciousness and collapse. As part of the treatment, in this case, you should rinse the stomach and take a sufficient amount of activated carbon. In addition, intravenous administration of a solution of sodium chloride (0.9%) should be performed. The active component of the drug valsartan is not excreted during dialysis due to active binding to blood plasma proteins.
Interaction with other medicines
When treating arterial hypertension with Valzom, there was no clinically significant interaction with other simultaneously used drugs, be it Cimetidine, Digoxin, Amlodipine, Furosemide, and so on.
According to the instructions for use with Valzu 40 mg (the same can be said for drugs with a higher dosage), all kinds of potassium-sparing diuretics along with salt preparations, for example, Heparin, can enhance the development of hyperkalemia. Other antihypertensive drugs along with diuretics enhance the antihypertensive effect.
The antihypertensive effect of the drug can be weakened when used together with non-steroidal anti-inflammatory drugs, including selective inhibitors and acetylsalicylic acid. In the case of combined use with inhibitors, a reverse increase in the concentration of lithium in the blood plasma is likely along with the development of toxic effects. To date, the experience of using valsartan with lithium-containing preparations is very limited. Thus, in the case of the use of medicines that contain lithium, it is recommended to control the level of this element in plasma.
What else can we be told by the instructions for use for Valz 80 mg tablets?
Special instructions for use
In patients with severe sodium deficiency in the body, for example, due to treatment with large doses of diuretics, in rare situations, severe arterial hypotension may appear at the beginning of Valzom therapy. Before starting treatment with this drug, it is recommended to restore electrolytes and fluid in the body, in particular by reducing the dosage of diuretics.
This drug can be used in combination with other drugs that are intended to treat a heart attack. For example, it can be used with thrombolytics, acetylsalicylic acid, adrenergic blockers, diuretics and statins. But the combined use with inhibitors is not recommended. Against the background of renovascular hypertension, constant monitoring of blood urea is required.
In the case of joint use with drugs that contain potassium, and drugs that belong to the group of potassium-sparing diuretics, regular monitoring of the amount of this element in the blood is carried out. Patients with heart failure who begin treatment with Valz may experience a decrease in pressure, and therefore it is recommended to monitor this indicator at the beginning of therapy. Patients with bilateral renal artery stenosis require regular monitoring of the amount of urea nitrogen and creatinine in the blood.
The effect of the drug on the ability to control complex and heavy mechanisms
During therapy with this medication, care must be taken while driving. It is also not recommended during this period to engage in various potentially dangerous activities that require special attention and speed of reactions.
So it is said in the instructions for use for tablets "Valz 80 mg." The same information is contained in the annotation for drugs with a different dosage.
Analogs
Among the most popular analogues of this drug are the following drugs:
- The drug "Valsartan." This tool is a cheaper substitute with the same active ingredient in the composition. This medicine is also sold exclusively in tablet form. This analogue is sold in packs of thirty. Among its main indications are hypertension along with chronic heart failure. This is indicated by the instructions for use. Analogs "Valza 80 mg" (or any other dosage) should be selected by the doctor.
- The drug "Valaar" is another analogue. This medicine also has a lower cost compared to Valz with almost the same packaging capacity. In this case, valsartan is also used as the active substance. The dosage of the active ingredient is the same as that of Valza: 40 milligrams per tablet. This analogue has some contraindications, and in addition, age restrictions.
- Tantordio is a more expensive Indian counterpart. Its active component is also valsartan. This analogue contains absolutely the same list of indications for use as Valz. Among the contraindications to the use of the presented analogue, pregnancy is listed along with lactation and children under the age of eighteen.
We reviewed the instructions for use with Valzu. 160 mg, 80 or 40 mg is the dosage of the active substance of the drug.
What do patients say?
Instructions for use and reviews on "Valz 160 mg" are of interest to many. So, the first thing you can read in the reviews about this medication is that it helps with hypertension. People in their comments call these pills an excellent cure for pressure with tangible benefits for blood vessels.
First of all, patients report on the effectiveness of the drug and its quality. Its relative availability is also noted. For example, many write that they consider the cost of the drug (from four hundred to nine hundred rubles) quite affordable to the majority of the population. , , .
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