"Apomorphine hydrochloride" is most often used to produce a negative reflex to alcohol. The drug has a weak analgesic effect, exerting a depressing effect on the respiratory center. Especially pronounced is the effect of the drug on the chemoreceptors of the medulla oblongata, the activation of which determines its strong emetic effect. Like morphine, this medicine inhibits the vomiting center. If the initial use of Apomorphine did not work, then repeated administration is most often ineffective.
Drug action
The use of "Apomorphine" also does not give a result if the patient is weakened by the excitability of the vomiting center or trigger zone. Vomiting occurs within fifteen to twenty minutes after subcutaneous administration of the drug and usually happens two to three times. Patients suffering from alcoholism with the help of Apomorphine help develop a negative conditioned reflex reaction to alcoholic beverages (ethanol). The drug has a weak analgesic effect.
Store Apomorphine in a cool dark place.
The drug is produced in the following forms:
- powder;
- ampoules;
- capsules.
Indications for use
"Apomorphine" is prescribed for chronic alcoholism (all stages). And also for quick elimination from the body of poor-quality food (if there is no way to wash the patient’s stomach). It is very rarely used as an expectorant in the form of an Apomorphine hydrochloride medicine.
Contraindications
Apomorphine is not taken if there are the following symptoms and diseases:
- severe heart disease;
- atherosclerosis;
- open form of pulmonary tuberculosis;
- diseases with a tendency to pulmonary hemorrhage;
- stomach ulcer;
- disease of the initial small intestine in humans;
- burns of the stomach with alkaline earth metals;
- organic damage to the central nervous system.
Also, the drug is not prescribed for the elderly and children under two years of age.
Side effects
Like any other drug, Apomorphine has a number of side effects:
- a rapid drop in blood pressure;
- the emergence of optical illusions and images that become realistic in nature;
- various disorders and pathologies of the nervous system (with a disease that is a consequence of intense craniocerebral injuries);
- hypersensitivity of the body's immune system when it comes in contact with an irritant - skin rash, itching, redness, irritation.
With a sharp drop in blood pressure, you need to drink a cardiovascular drug as soon as possible, and then the patient must take a horizontal position.
We must remember!
It should be taken "Apomorphine hydrochloride" by prescription. Without consulting a specialist, this is not worth it.
"Apomorphine hydrochloride": instructions for use
Usually, the medicine is prescribed in the form of a syrup:
- adult patients - from 0.001 to 0.005 grams;
- children from 2 to 5 years old are allowed to take from 0.0005 to 0.001 grams;
- children from six to twelve years of age are prescribed a dosage from 0.001 to 0.0025 grams.
How an emetic medicine begins to act a few minutes after the injection, which is placed directly in the fat layer under the skin:
- The dosage for adults is from 0.002 to 0.005 grams (1% solution).
- Dosage for children varies from 0.001 to 0.003 grams (allowed for children from two years).
The maximum single dose for an adult is 0.005 grams under the skin, inside - 0.01 grams.
In narcology, "Apomorphine hydrochloride" is prescribed to get rid of alcoholism.
In order for a negative conditioned reflex reaction to ethanol to occur, “Apomorphine” is administered under the skin in a single dosage from 0.002 to 0.01 grams, the dose is selected individually so that it can cause vomiting in the patient. After three to four minutes, the patient is allowed to drink alcohol in the amount of 30-50 milliliters.
If nausea occurs, the patient is offered to drink a little alcoholic drink, after which it is necessary to sniff it and rinse your mouth. When the aversion to alcohol rises and the patient feels that vomiting is approaching, he should drink another sip of a strong drink. As a rule, after the appearance of nausea, vomiting occurs after ten to fifteen minutes. Such procedures are carried out once or twice a day.
To obtain a persistent negative reaction to strong drinks (vomiting), you need from twenty to thirty procedures. For therapy, as well as the prevention of alcohol withdrawal and a constant attraction to alcohol, the drug should be used as follows:
- the medicine is given in gelatin capsules (in order to avoid irritation of the oral mucosa);
- for the first time you need to take no more than 10 milligrams of Apomorphine;
- then during the day it is necessary to gradually increase the dosage by 10 milligrams to a feeling of nausea;
- the duration of treatment is from five to seven days.
To increase absorption, it is necessary to give “Apomorphine hydrochloride” to an alcoholic patient after a meal that is saturated with fats and proteins.