"Sustagard Artro" acts as a drug that stimulates the process of regeneration of cartilage tissue. This medication has anti-inflammatory and analgesic effects on the body. For ampoules "Sustagard Artro" instructions and reviews will be presented below.
The form of release of the drug and its composition
The drug is produced in the form of ampoules. Each of them contains glucosamine sulfate, the active substance, as well as sodium chloride. As additional components, the drug includes sodium disulfite, lidocaine hydrochloride, as well as high concentration hydrochloric acid and water for injection.
This is indicated by the instruction attached to Sustagard Arthro. We will consider the prices later.
Pharmacological properties of the drug
The drug works as a stimulator of regeneration, and also performs anti-catabolic, anti-inflammatory, chondroprotective, analgesic and anabolic effects on the body.
The active substance of this medication, which is glucosamine sulfate, is contained in the human body and serves as a salt. Sustagard Artro activates the production of proteoglycans by means of chondrocytes and synovial fluid, thus suppressing enzymes that lead to the destruction of cartilage tissue. In addition, the drug counteracts the formation of superoxide radicals, reducing the activity of lysosomal enzymes and providing a normal process of calcium deposition in bone tissues. This stimulates the process of sulfur production during the synthesis of chondroitin sulfuric acid, while avoiding the damaging effects of corticosteroids. There is also a normalization of glycosaminoglycan production, which is disturbed due to non-steroidal anti-inflammatory drugs.
Sulfo groups are involved in the metabolic processes of cartilage and in the formation of glycosaminoglycans. Elements such as sulfoesters are able to retain water, while maintaining the elasticity of the cartilage. This confirms the instructions for use for the drug "Sustagard Artro". The price interests many.
With osteoarthritis, glucosamine sulfate reduces the frequency of occurrence, as well as the severity of the symptoms of this disease, preventing the destruction of cartilage. The weakening of clinical symptoms is usually noted a couple of weeks after the start of the course. The achieved improvement can persist for two months after the completion of the use of this drug.
Glucosamine sulfate is characterized by rapid passage through biological obstacles, followed by penetration into the structure of tissues, especially in areas of articular cartilage. The elimination period is approximately sixty hours.
According to reviews of Sustagard Artro ampoules, instructions are included in each package.
Indications for use of the drug
This medication should be used for such ailments as:
- Chondromalacia of the patella.
- Spondylarthrosis.
- Primary or secondary osteoarthrosis.
- The presence of osteochondrosis.
- Spondylosis and shoulder-shoulder periarthritis.
Contraindications
According to the instructions for use with the drug "Sustagard Artro", the list of contraindications for the use of the drug is quite extensive. Therefore, it should not be used under the following restrictions:
- The presence of phenylketonuria.
- Age to twelve years.
- Sensitivity to any of the components of the drug.
- The presence of acute heart failure along with impaired conduction.
- Period of pregnancy.
- Pathology of hepatic or renal function.
- The likelihood of epileptiform seizures.
Also, with Sustagard, the instructions for use report that with special care should be treated with the drug in conditions such as:
- Arterial hypotension.
- Circulatory pathology.
- The tendency of the patient to malignant hyperthermia.
- Respiratory system diseases.
- Epilepsy and advanced age.
In the event that the patient has a tendency to intolerance to various seafood, then during treatment with the drug there is a risk of allergic reactions of the body.
This is confirmed by the instructions and reviews for Sustagard Artro ampoules.
Dosage and route of administration
The solution of the drug "Sustagard Artro" is intended exclusively for intramuscular administration. An intravenous route of infusion is strictly contraindicated.
To prepare the medicine, the contents of the ampoule “A” should be mixed with solvent “B”, this is done in one syringe before the injection procedure. The finished solution is administered three times a week in the amount of three milliliters per day. The course of treatment is usually from four to six weeks.
Sustagard Artro powder also has very detailed instructions for use.
Side effects of the drug
In the framework of the use of the drug, the appearance of such undesirable effects as various allergic reactions, for example, itching and urticaria. In addition, flatulence, constipation and diarrhea are not excluded. Against the background of the use of an injection solution, the following reactions are also likely due to the influence of lidocaine:
- Impaired cardiac conduction function.
- The appearance of dizziness, diplopia, pain, numbness of the mucous membrane of the oral cavity and tongue. In addition, disorientation along with tremors, drowsiness, and euphoria can be observed on the part of the nervous system.
- As part of allergic reactions, anaphylactic shock can occur. Sometimes there are swelling.
- The appearance of nausea and vomiting.
- A slight burning sensation may occur with the appearance of an anesthetic effect, which, as a rule, passes within one minute. Thrombophlebitis is also not excluded.
Sodium disulfite contained in the solution in rare situations can provoke the occurrence of bronchospasm, as well as severe reactions associated with hypersensitivity.
What else does the instructions for use tell Sustagard Artro ampoules?
Drug overdose
Cases of drug overdose have not yet been recorded. Symptoms of this condition, which can be caused by the action of an additional ingredient of the solution in the form of lidocaine hydrochloride, can be the presence of tinnitus, tremors, dizziness, drowsiness, anxiety, depression, an excited state, blurred vision, numbness of the lips and tongue.
In case of suspicion of an overdose, respiratory function and proper functioning of the cardiovascular system should be monitored. If changes are found that correspond to the above parameters, then this will indicate the use of the drug in doses significantly exceeding the permissible norms. As a result, the patient will need immediate access to oxygen. Thus, if any complications occur, symptomatic treatment should be initiated.
Special instructions for the use of Sustagard Artro ampoules
Instructions for use indicate that the injection solution should be used with caution in the event of bronchial asthma, or impaired susceptibility to glucose. Patients who follow a strict salt-free diet should take into account that forty milligrams of sodium are contained in a single dose of the drug. Before intramuscular injection, a skin test is required to establish the presence of individual sensitivity to lidocaine. When conducting this experiment, it is important to know that such sensitivity is expressed by the appearance of edema and redness of the injection site.
During the treatment with this drug, it is important to be careful when driving, or when using equipment, which requires an increased concentration of attention. This is because after the introduction of injections of the drug, the appearance of sudden dizziness, drowsiness and double vision in the eyes is likely. This is confirmed by the instructions and reviews for Sustagard Artro ampoules. Analogs will be considered below.
Drug Interactions
Glucosamine sulfate can be used in combination with non-steroidal anti-inflammatory drugs, as well as glucocorticosteroids and paracetamol, including. When using this product with penicillins, the absorption of substances from the digestive tract decreases, and in the case of taking with tetracyclines, on the contrary, it increases. The reactions observed when combining lidocaine, which is contained in the solution of Sustagard Arthro with other drugs, are usually as follows:
- At "Phenytoinum" there is an increase in the cardiodepressive effect of lidocaine.
- As part of a combination with antiarrhythmic drugs, such as Disisopyramide and Quinidine, an atrioventricular block develops, or ventricular fibrillation can occur.
- Against the background of “Peptidine”, “Propranolol”, “Cimetidine” and “Chlorpromazine”, the concentration of lidocaine in the blood plasma increases, and the hepatic metabolism of this substance is also significantly reduced.
- Under the influence of ethanol, there is an increase in the inhibitory effect of lidocaine on respiration. And in combination with Procainamide, hallucinations and delusions are likely to occur.
- Medicines that have a sedative effect, when combined with Sustagard Artro, are enhanced by their calming effect.
- Medications that determine blocking of neuromuscular transmission increase the effect due to a decrease in the degree of conduction of impulses of the nervous system according to the instructions for Sustagard Artro ampoules. According to reviews, the price is quite high.
Analogues of the drug
Analogs of this drug are solutions intended for intramuscular administration, which are the medical means of "Don" and "Elbon". Before replacing the prescribed drug with one of these analogues, the patient should definitely consult with your doctor.
Storage and dispensing conditions
According to the instructions and reviews, Sustagard Artro ampoules are dispensed in pharmacies strictly by prescription. Store this medication in a dry, dark, and cool place that is not accessible to children. The shelf life of the product is two years from the date of issue. In Russian pharmacies, the average price of the drug is seven hundred and fifty rubles.
Reviews about the drug "Sustagard Artro"
The few reviews on the Internet about the drug Sustagard Artro are mostly positive. People who used this drug note its effectiveness in the treatment of osteoarthritis, arthrosis, as well as osteochondrosis.
People write that this medication significantly alleviates the symptoms of diseases, having an analgesic effect. In some situations, patients experience a feeling of slight soreness during the injection, which persists for some time.
There are no complaints about any side effects in the comments. But at the same time, the main drawback of the drug is an extensive list of contraindications, since Sustagard Artro can be taken not by all patients. For this reason, before you begin treatment with this medicine, you must undergo a medical examination and get advice from your doctor.
We reviewed the instructions for the use of the solution for Sustagard Artro, as well as reviews and analogues.