Is a drug like Tenoric effective? Everyone can leave a review about this drug . Thanks to such reports, both doctors and patients can easily conclude how the medication mentioned works, whether it causes adverse reactions and copes with the task.
In this article we will describe in detail the properties and characteristics of the drug "Tenorik". The response of the patient taking it as prescribed by the doctor will also be presented a little lower.
Composition, form, description, packaging
The drug "Tenoric" (100, 50 mg) goes on sale in the form of white tablets with a round and biconvex shape with a dividing line.
The composition of this medication includes two active components: chlortalidone and atenolol. Also, this drug contains additional components, which are presented in the form of corn starch, sodium lauryl sulfate, lactose, polyvinylpyrrolidone, talc, silicon dioxide, isopropanol and magnesium stearate.
It is impossible not to say that the tablets "Tenorik" (a review of this tool you can see at the end of the article) are covered with a special film coating. It consists of methylene chloride, isopropanol, talc, hypromellose, titanium dioxide, macrogol and liquid paraffin.
You can buy the drug in question in blisters or strips of 100 or 28 tablets.
Pharmacology of the drug
What are Tenoric tablets? Instructions for use (the price of the drug is not very high) reports that it is an antihypertensive combination drug that can have a long hypotensive effect.
The effectiveness of the drug in question is due to the action of 2 components, more specifically, a diuretic (chlortalidone) and beta1-blocker (atenolol).
Basic properties
Atenolol is called a cardioselective beta1-blocker. The selective ability of this substance decreases with increasing dosage of the drug. Atenol has no internal membrane-stabilizing and sympathomimetic effects. Like other beta-blockers, it has a negative inotropic effect and significantly reduces heart rate.
As for chlortalidone, it is a diuretic (sulfonamide nontiazide). It enhances the release of elements such as chlorine and sodium. Also, this component increases the release of bicarbonate, magnesium and potassium. The principle of its antihypertensive effect is associated with sodium excretion.
The combination of atenolol with diuretics is more effective than the use of each of the mentioned components separately.
The effect of the medication in question persists throughout the day (after a single dose in a daily dosage).
Kinetics of medication
Due to the fact that the drug "Tenorik", analogues, the price of which is presented below, is a combined tool, we consider the kinetic properties of each of the active substances separately.
Atenolol is absorbed by 40-50% from the gastrointestinal tract. Its maximum concentration is reached 4 hours after taking the pill. Communication with proteins is approximately 8-16%.
Atenolol does not undergo a pronounced metabolism in the liver. About 90% of the absorbed substance is excreted unchanged within 8-9 hours. This period can be increased with severe renal failure, since the elimination of atenolol is carried out through the kidneys.
As for chlortalidone, it is 60% absorbed from the digestive tract. In blood plasma, its maximum concentration is reached after 12 hours. Protein binding is approximately 75%.
Chlortalidone is excreted via the kidneys within 50 hours.
Indications for use
The drug in question helps very well from high blood pressure. Actually, arterial hypertension is the main and, perhaps, the only indication for use.
Contraindications
Now you know for what purpose Tenorik tablets can be prescribed (indications for taking this medicine were presented above). But, unfortunately, the medication in question has a rather impressive list of contraindications. It is not recommended for use with:
- shock cardiogenic;
- pheochromocytoma;
- bradycardia (severe seizures);
- severe disturbances in peripheral circulation;
- arterial hypotension (progressive and severe);
- metabolic acidosis;
- AV blockade of the 1st and 3rd degree;
- SSSU;
- progressive bronchial asthma;
- heart failure (both acute and chronic);
- diabetes mellitus;
- vasospastic angina (Prinzmetal angina);
- gout
- obstructive bronchitis;
- acute hepatitis;
- hypoglycemia;
- acute renal failure;
- under the age of 18;
- myasthenia gravis;
- hypersensitivity to the ingredients of the drug.
How to take "Tenorik" from high blood pressure?
For adult patients, this drug is recommended to be taken in an average dosage of 100 mg. In this case, the initial dose of the drug should be 50 mg once a day.
As for the elderly, the drug "Tenorik" they are prescribed in even smaller quantities.
It is advisable for patients with impaired renal function to reduce the frequency of taking the pills.
It should also be noted that after prolonged use of the medication in question, its withdrawal must be carried out gradually.
Side effects
Taking tablets "Tenorik" can provoke the appearance of the following adverse reactions:
- bradycardia, increased signs of heart failure, cold extremities, orthostatic hypotension, arrhythmia, AV block, symptoms of intermittent claudication, Raynaud's syndrome ;
- confusion, apathy, headaches, hallucinations, acute psychosis, paresthesias, mood swings, dizziness, increased fatigue, sleep disturbance, disorientation, visual impairment;
- dry mouth, increased liver transaminases, gastrointestinal upsets, hepatotoxicity with intrahepatic cholestasis, pancreatitis, nausea, constipation, anorexia;
- leukopenia, purpura, thrombocytopenia, eosinophilia, agranulocytosis;
- alopecia, psoriasis-like reactions, dry eyes, exacerbation of psoriasis, photosensitivity, skin rash;
- bronchospasm, hyperuricemia, hypokalemia, hyponatremia;
- impaired glucose tolerance, an increase in the number of antinuclear antibodies, a decrease in potency.
The listed side effects are extremely rare and poorly expressed.
Price, analogues
The cost of Tenorik tablets is 110-120 rubles. You can replace them with drugs such as Atenol, Dinoric, or Tenoret.
Reviews about the medicine "Tenorik"
Everyone can leave feedback on the effectiveness of this tool. According to patients and doctors, the main advantages of this tool are:
The disadvantages of this drug include:
- the likelihood of hair loss and impotence (with prolonged treatment);
- the likelihood of seizures.